| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3481 |
Name | IGF2 |
Synonymous | C11orf43|IGF-II|PP9974;insulin-like growth factor 2 (somatomedin A);IGF2;insulin-like growth factor 2 (somatomedin A) |
Definition | insulin-like growth factor II|insulin-like growth factor type 2|somatomedin-A |
Position | 11p15.5 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IGF-2(h) + IBP-1(h) <==> IGF-2(h):IBP-1(h) (binding) | IGF-2(h) + IGFBP-2(h) <==> IGF-2(h):IGFBP-2(h) (binding) | IGF-2(h) + IGFBP-2(r) <==> IGF-2(h):IGFBP-2(r) (binding) | IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding) | IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding) | IGF-2(h) + IGFBP-4(r) <==> IGF-2(h):IGFBP-4(r) (binding) | IGF-2(h) + IGFBP-5(h) <==> IGF-2(h):IGFBP-5(h) (binding) | IGF-2(h) + IGFBP-6(h) <==> IGF-2(h):IGFBP-6(h) (binding) | IGF-2(h) + IGFBP-2(b) <==> IGF-2(h):IGFBP-2(b) (binding) | IGF-2(h) + IGFBP-2(h) <==> IGF-2(h):IGFBP-2(h) (binding) | IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding) | IGF-2(h) + IGFBP-4(h) <==> IGF-2(h):IGFBP-4(h) (binding) | IGF-2(h) + IGFBP-5(h) <==> IGF-2(h):IGFBP-5(h) (binding) | ALS(h) + IGF-2(h) + IGFBP-3(h) <==> ALS(h):IGF-2(h):IGFBP-3(h) (binding) | ALS(h) + IGF-2(h) + IGFBP-5(h) <==> ALS(h):IGF-2(h):IGFBP-5(h) (binding) | IGF-2(h) --> progesterone (increase of secretion) | IGF-2(h) --> CYP19A1(b) (transactivation) | IGF2(h) --> IGF-2(h) (expression). | IGF2(h) --> IGF-2-isoform1(h) (expression). | IGF2(h) --> IGF-2-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 99 | O-linked (GalNAc...). | Swiss-Prot 53.0 | 95 | O-linked | 1:Daughaday WH., Trivedi B. and Baxter, RC. (1993) Proc. Natl. Acad. Sci., 90, 5823-5827. Medline: 93296232;2:Duguay SJ., Jin Y., Stein J., Duguay AN., Gardner P. and Steiner DF. (1998) J. Biol. Chem., 273, 18443-18451. Medline: 98325057; | OGlycBase6.0 | 96 | O-linked | 1:Daughaday WH., Trivedi B. and Baxter, RC. (1993) Proc. Natl. Acad. Sci., 90, 5823-5827. Medline: 93296232;2:Duguay SJ., Jin Y., Stein J., Duguay AN., Gardner P. and Steiner DF. (1998) J. Biol. Chem., 273, 18443-18451. Medline: 98325057; | OGlycBase6.0 | 99 | O-linked | 1:Daughaday WH., Trivedi B. and Baxter, RC. (1993) Proc. Natl. Acad. Sci., 90, 5823-5827. Medline: 93296232;2:Duguay SJ., Jin Y., Stein J., Duguay AN., Gardner P. and Steiner DF. (1998) J. Biol. Chem., 273, 18443-18451. Medline: 98325057; | OGlycBase6.0 | 163 | O-linked | 1:Daughaday WH., Trivedi B. and Baxter, RC. (1993) Proc. Natl. Acad. Sci., 90, 5823-5827. Medline: 93296232;2:Duguay SJ., Jin Y., Stein J., Duguay AN., Gardner P. and Steiner DF. (1998) J. Biol. Chem., 273, 18443-18451. Medline: 98325057; | OGlycBase6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 2116280 - 2118280 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 2126909 - 2128909 | GSE27584 |
chr11 |
Promoter: 2116280 - 2118280 | GSE27584 |
chr11 |
Promoter: 2116280 - 2118280 | E-GEOD-20553 |
chr11 |
Promoter: 2126909 - 2128909 | E-GEOD-20553 |
chr11 |
Promoter: 2116280 - 2118280 | PMID:17372756 |
chr11 |
Promoter: 2126909 - 2128909 | PMID:17372756 |