| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3297 |
Name | HSF1 |
Synonymous | HSTF1;heat shock transcription factor 1;HSF1;heat shock transcription factor 1 |
Definition | HSF 1|HSTF 1|heat shock factor protein 1 |
Position | 8q24.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | HSF1-L(h) --> hsp70(d) (DNA binding). | HSF1-L(h) --> HSPA1A(h) (DNA binding). | 2 HSF1-L(h) <==> HSF1-L(h):HSF1-L(h) (binding). | HSF1-L(h) --> SOD1(r) (DNA binding). | HSF1-L(h) --> CCT2(m) (DNA binding; transactivation). | HSF1-L(h) --> CCT4(m) (DNA binding; transactivation). | HSF1-L(h) --> Cct5(m) (DNA binding; transactivation). | HSF1-L(h) --> Cct7(m) (DNA binding; transactivation). | HSF1-L(h) --> Tnf(m) (DNA binding). | HSF1-L(h) --> TCP1(m) (DNA binding; transactivation). | HSF1-L(h) --> CCT3(m) (DNA binding; transactivation). | HSF1-L(h) --> Cct6a(m) (DNA binding). | HSF1-L(h) --> CCT8(m) (DNA binding; transactivation). | HSF1-L(h) + C/EBPbeta(m.s.) <==> HSF1-L(h):C/EBPbeta(m.s.) (binding) | HSF1-L(h) + HSF2A(h) <==> HSF1-L(h):HSF2A(h) (binding) | HSF1-L(h) + HSF2B(h) <==> HSF1-L(h):HSF2B(h) (binding) | HSF1-L(h) + TBP(h) <==> HSF1-L(h):TBP(h) (binding) | HSF1-L(h) + TFIIB(h) <==> HSF1-L(h):TFIIB(h) (binding) | HSF1-L(h) + TFIIA-gamma(h) <==> HSF1-L(h):TFIIA-gamma(h) (binding) | PC4(h) + HSF1-L(h) <==> PC4(h):HSF1-L(h) (binding) | HSF1-L(h) + TAF(II)55(h) <==> HSF1-L(h):TAF(II)55(h) (binding) | HSF1-L(h) + CBP(m.s.) <==> HSF1-L(h):CBP(m.s.) (binding) | HSF1-L(h) + ASC-2(h) <==> HSF1-L(h):ASC-2(h) (binding) | HSF1-L(h) + RIP1(h) <==> HSF1-L(h):RIP1(h) (binding) | HSF1-L(h) + RIP1(h) + Hsp90(h) + alpha-tubulin(h) <==> HSF1-L(h):RIP1(h):Hsp90(h):alpha-tubulin(h) (binding) | HSF1-L(h) + ATP --CKII-alpha(b):CKII-alpha2(b):(CKII-beta(b))2--> HSF1-L(h){pS} + ADP (phosphorylation) | HSF1-L(h) + sumo1(h) --> HSF1-L(h){sumoK298} (sumoylation) | HSF1-L(h) + 2 ATP --> HSF1-L(h){pS303}{pS307} + 2 ADP (phosphorylation) | HSF1-L(h) + Daxx(h) <==> HSF1-L(h):Daxx(h) (binding) | HSF1(h) --> HSF1-L(h) (expression). | HSF1-S(h) --> hsp70(d) (DNA binding). | HSF1-S(h) --> HSPA1A(h) (DNA binding). | HSF1(h) --> HSF1-S(h) (expression). | HSF1(h) + ATP --RSK2(rb)--> HSF1(h){p} + ADP (phosphorylation) | HSF1(h) + Ku70(h):Ku80(h) <==> HSF1(h):Ku70(h):Ku80(h) (binding) | HSF1(h) + DNA-PKcs(h) <==> HSF1(h):DNA-PKcs(h) (binding) | HSF1(h) + DNA-PK(h) <==> HSF1(h):DNA-PK(h) (binding) | HSF1(h) + ATP --ERK1(m)--> HSF1(h){pS307} + ADP (phosphorylation) | HSF1(h) + ATP --ERK1(v.s.)--> HSF1(h){pS307} + ADP (phosphorylation) | HSF1(h) + ATP --CaMKII(v.s.)--> HSF1(h){pS230} + ADP (phosphorylation) | HSF1(h) + ATP --ERK1(h)--> HSF1(h){pS307} + ADP (phosphorylation) | HSF1(h) + ATP --JNK1(h)--> HSF1(h){pS307} + ADP (phosphorylation) | ERK1(v.s.) + HSF1(h) <==> ERK1(v.s.):HSF1(h) (binding) | JNK1(v.s.) + HSF1(h) <==> JNK1(v.s.):HSF1(h) (binding) | HSF1(h) + ATP --PKCalpha(rb)--> HSF1(h){pS363} + ADP (phosphorylation) | HSF1(h) + ATP --ERK1(h)--> HSF1(h){p} + ADP (phosphorylation) | HSF1(h) + STAT1(h) <==> HSF1(h):STAT1(h) (binding) | HSF1(h) --> HSPA7(h) (transactivation) | TAF(II)31(h) + HSF1(h) <==> TAF(II)31(h):HSF1(h) (binding) | Ku70(h) + HSF1(h) <==> Ku70(h):HSF1(h) (binding) | HSF1(h) + Symplekin(h) <==> HSF1(h):Symplekin(h) (binding) | HSF1(h) + CstF-64(h) <==> HSF1(h):CstF-64(h) (binding) | HSF1(h) + Hsp70(h) <==> HSF1(h):Hsp70(h) (binding) | HSF1(h) + ASC-2(h) <==> HSF1(h):ASC-2(h) (binding) | HSF1(h) + RIP1(h) <==> HSF1(h):RIP1(h) (binding) | HSF1(h) + RIP1(h) <==> HSF1(h):RIP1(h) (binding) | HSF1(h) --> HSF1(h) (translocation) | 2 ATP + HSF1(h) --> 2 ADP + HSF1(h){pS307}{pS303} (phosphorylation) | HSF1(h) --> HSPA1A(h) (transactivation) | HSF1(h) --> HSP 17.7(HELAN) (DNA binding). | HSF1(h) --> ABCB1(h) (DNA binding; transactivation). | HSF1(h) --> HMOX1(h) (DNA binding; transactivation). | HSF2(h) + HSF1(h) <==> HSF1(h):HSF2(h) (binding) | HSF1(h) --> Clu(r) (DNA binding). | HSF1(h) --> bag3(h) (increase of abundance) | HSF1(h) --> BRS3(h) (DNA binding). | tpr(h) + HSF1(h) <==> tpr(h):HSF1(h) (binding) | HSF1(h) --> HSPA1A(r) (DNA binding). | HSF1(h) --> HSF1(h) (expression). | HSF1(h) --> HSF1(h) (translocation) |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 303 | Phosphoserine. | Swiss-Prot 53.0 | 307 | Phosphoserine. | Swiss-Prot 53.0 | 323 | Phosphothreonine. | Swiss-Prot 53.0 | 363 | Phosphoserine. | Swiss-Prot 53.0 | 323 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 444 | Phosphoserine | 15760475 | Phospho.ELM 6.0 | 292 | Phosphoserine | 15760475 | Phospho.ELM 6.0 | 319 | Phosphoserine | 15760475 | Phospho.ELM 6.0 | 344 | Phosphoserine | 15760475 | Phospho.ELM 6.0 | 419 | Phosphoserine | 15760475 | Phospho.ELM 6.0 | 314 | Phosphoserine | 15760475;17081983 | Phospho.ELM 6.0 | 326 | Phosphoserine | 15760475 | Phospho.ELM 6.0 | 121 | Phosphoserine (MAPKAPK2) | 16278218 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr8 |
Promoter: 145484591 - 145486591 | GSE27584 |
chr8 |
Promoter: 145484591 - 145486591 | Agilent_014791_44K |