| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2670 |
Name | GFAP |
Synonymous | -;glial fibrillary acidic protein;GFAP;glial fibrillary acidic protein |
Definition | - |
Position | 17q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | menin(m.s.) + GFAP-alpha(h) <==> menin(m.s.):GFAP-alpha(h) (binding) | 2 GFAP-alpha(h) <==> (GFAP-alpha(h))2 (oligomerization) | GFAP-alpha(h) + NFL(m.s.) <==> GFAP-alpha(h):NFL(m.s.) (binding) | GFAP-alpha(h) + peripherin(m.s.) <==> GFAP-alpha(h):peripherin(m.s.) (binding) | GFAP-alpha(h) + INA(m.s.) <==> GFAP-alpha(h):INA(m.s.) (binding) | GFAP-alpha(h) + Periplakin(m.s.) <==> GFAP-alpha(h):Periplakin(m.s.) (binding) | GFAP-alpha(h) + EVPL(m.s.) <==> GFAP-alpha(h):EVPL(m.s.) (binding) | DMN(h) + GFAP-alpha(h) <==> DMN(h):GFAP-alpha(h) (binding) | GFAP(h) --> GFAP-alpha(h) (expression). | GFAP(h) + 3 ATP --Aurora-B(r)--> 3 ADP + GFAP(h){pT7}{pS13}{pS38} (phosphorylation) | GFAP(h) + 3 ATP --ROCK-II(b)--> 3 ADP + GFAP(h){pT7}{pS13}{pS38} (phosphorylation) | GFAP(h) + 4 ATP --PKAc(m.s.)--> GFAP(h){pY7}{pS8}{pS13}{pS38} + 4 ADP (phosphorylation) | GFAP(h) + 3 ATP --ROCK-II(b)--> GFAP(h){pT7}{pS13}{pS38} + 3 ADP (phosphorylation) | GFAP(h) + menin(m.s.) <==> GFAP(h):menin(m.s.) (binding) | PS1(m.s.) + GFAP(h) <==> PS1(m.s.):GFAP(h) (binding) | GFAP(h) --proCaspase-3(h)--> GFAP-p20(h) + protein remnants (cleavage) | GFAP(h) --> GFAP-p20(h) + protein remnants (cleavage) | GFAP(h) --proCaspase-3(h)--> GFAP-p30(h) + protein remnants (cleavage) | GFAP(h) --proCaspase-7(h)--> GFAP-p30(h) + protein remnants (cleavage) | GFAP(h) + NHERF3(h) <==> GFAP(h):NHERF3(h) (binding) | GFAP(h) + vimentin(h) <==> GFAP(h):vimentin(h) (binding) | GFAP(h) + elfin(h) <==> GFAP(h):elfin(h) (binding) | GFAP(h) + LMP(h) <==> GFAP(h):LMP(h) (binding) | GFAP(h) + Grap2(h) <==> GFAP(h):Grap2(h) (binding) | GFAP(h) + FLJ43995(h) <==> GFAP(h):FLJ43995(h) (binding) | GFAP(h) + POM121(h) <==> GFAP(h):POM121(h) (binding) | GFAP(h) + ribc2(h) <==> GFAP(h):ribc2(h) (binding) | GFAP(h) + sh3yl1(h) <==> GFAP(h):sh3yl1(h) (binding) | GFAP(h) + GCP-4(h) <==> GFAP(h):GCP-4(h) (binding) | GFAP(h) + cep76(h) <==> GFAP(h):cep76(h) (binding) | GFAP(h) + myo15b(h) <==> GFAP(h):myo15b(h) (binding) | GFAP(h) --> GFAP(h) (expression). | PS1(m.s.) + GFAP-epsilon(h) <==> PS1(m.s.):GFAP-epsilon(h) (binding) | GFAP-epsilon(h) + Periplakin(m.s.) <==> GFAP-epsilon(h):Periplakin(m.s.) (binding) | GFAP-epsilon(h) + EVPL(m.s.) <==> GFAP-epsilon(h):EVPL(m.s.) (binding) | GFAP(h) --> GFAP-epsilon(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 110 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 383 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 8 | Phosphoserine (CDK1) | 12177195;7822264 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 40347894 - 40349894 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 40347894 - 40349894 | GSE27584 |
chr17 |
Promoter: 40347894 - 40349894 | PMID:8702246 |