| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 238 |
Name | ALK |
Synonymous | CD246|NBLST3;anaplastic lymphoma receptor tyrosine kinase;ALK;anaplastic lymphoma receptor tyrosine kinase |
Definition | ALK tyrosine kinase receptor|CD246 antigen|mutant anaplastic lymphoma kinase |
Position | 2p23 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | alk(h) + ATP --> alk(h){p} + ADP (automodification) | alk(h) --Caspase-3(m.s.)--> alk-p60(h) + protein remnants (cleavage) | ALK(h) --> alk(h) (expression). | alk(h) + ATP --> alk(h){pY} + ADP (phosphorylation) | alk(h) + Shc-1(h) <==> alk(h):Shc-1(h) (binding) | alk(h) + c-Cbl(h) <==> alk(h):c-Cbl(h) (binding) | ALK(h) --> alk(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 169 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 211 | Phosphoserine. | Swiss-Prot 53.0 | 244 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 285 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 324 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 411 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 424 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 445 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 563 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 571 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 627 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 709 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 808 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 863 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 864 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 886 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 986 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1078 | Phosphotyrosine. | Swiss-Prot 53.0 | 1092 | Phosphotyrosine. | Swiss-Prot 53.0 | 1096 | Phosphotyrosine. | Swiss-Prot 53.0 | 1131 | Phosphotyrosine. | Swiss-Prot 53.0 | 1278 | Phosphotyrosine. | Swiss-Prot 53.0 | 1282 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1507 | Phosphotyrosine. | Swiss-Prot 53.0 | 1584 | Phosphotyrosine. | Swiss-Prot 53.0 | 1604 | Phosphotyrosine. | Swiss-Prot 53.0 | 1059 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1092 | Phosphotyrosine (ALK) | 15592455;9819383;11110708 | Phospho.ELM 6.0 | 1096 | Phosphotyrosine (ALK) | 15592455;9819383;11110708 | Phospho.ELM 6.0 | 1385 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1401 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1507 | Phosphotyrosine (ALK) | 15592455;9819383;11110708 | Phospho.ELM 6.0 | 1586 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1604 | Phosphotyrosine (ALK) | 15592455;9819383 | Phospho.ELM 6.0 | 1078 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 1584 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 1282 | Phosphotyrosine (ALK) | 9174053;9819383;11110708 | Phospho.ELM 6.0 | 1283 | Phosphotyrosine (ALK) | 9174053;9819383;11110708 | Phospho.ELM 6.0 | 1131 | Phosphotyrosine (ALK) | 15592455;9819383;11110708 | Phospho.ELM 6.0 | 1239 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1278 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1327 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1330 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 1359 | Phosphotyrosine (ALK) | 9819383;11110708 | Phospho.ELM 6.0 | 211 | Phosphoserine | 16565220 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 29997436 - 29999436 | Agilent_014791 |
chr2 |
Promoter: 29997436 - 29999436 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 29997436 - 29999436 | GSE27584 |