| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2322 |
Name | FLT3 |
Synonymous | CD135|FLK-2|FLK2|STK1;fms-related tyrosine kinase 3;FLT3;fms-related tyrosine kinase 3 |
Definition | CD135 antigen|FL cytokine receptor|FLT-3|FLT3 receptor tyrosine kinase|STK-1|fetal liver kinase 2|fetal liver kinase-2|fms-like tyrosine kinase 3|growth factor receptor tyrosine kinase type III|receptor-type tyrosine-protein kinase FLT3|stem cell tyrosine |
Position | 13q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | FLT3(h) + ATP --> FLT3(h){pY} + ADP (phosphorylation; automodification) | FLT3(h) + FLT3L(h) <==> FLT3(h):FLT3L(h) (binding) | FLT3(h) + ATP --> FLT3(h){p} + ADP (phosphorylation; automodification) | FLT3(h) --> FLT3(h) (expression). | TGFbeta1(h) --> FLT3(h) (decrease of abundance) | FLT3(h) --> FLT3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 43 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 100 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 151 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 306 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 323 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 351 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 354 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 473 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 502 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 541 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 589 | Phosphotyrosine (FLT3) | 11971190 | Phospho.ELM 6.0 | 591 | Phosphotyrosine (FLT3) | 11971190 | Phospho.ELM 6.0 | 597 | Phosphotyrosine (FLT3) | 11971190 | Phospho.ELM 6.0 | 599 | Phosphotyrosine (FLT3) | 11971190 | Phospho.ELM 6.0 | 842 | Phosphotyrosine | 15345593 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr13 |
Promoter: 27572229 - 27574229 | Agilent_014791 |
chr13 |
Promoter: 27572229 - 27574229 | GoldenGate_Methylation_Cancer_Panel_I |
chr13 |
Promoter: 27572229 - 27574229 | GSE27584 |
chr13 |
Promoter: 27572229 - 27574229 | Agilent_014791_44K |