| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2261 |
Name | FGFR3 |
Synonymous | ACH|CD333|CEK2|HSFGFR3EX|JTK4;fibroblast growth factor receptor 3;FGFR3;fibroblast growth factor receptor 3 |
Definition | FGFR-3|hydroxyaryl-protein kinase|tyrosine kinase JTK4 |
Position | 4p16.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | FGFR-3(h) + SH2-B-beta(m) <==> FGFR-3(h):SH2-B-beta(m) (binding) | FGFR-3(h) + SH2-B(m) <==> FGFR-3(h):SH2-B(m) (binding) | FGFR-3(h) + PLCgamma1(m) <==> FGFR-3(h):PLCgamma1(m) (binding) | FGFR-3(h) + SH2-B-beta(r) <==> FGFR-3(h):SH2-B-beta(r) (binding) | FGFR-3(h) + ANT3(h) <==> FGFR-3(h):ANT3(h) (binding) | FGFR-3(h) + L8(h) <==> FGFR-3(h):L8(h) (binding) | FGFR-3(h) --> FOXN1(h) (transactivation) | FGFR3(h) --> FGFR-3(h) (expression). | FOXN1(h) --> FGFR-3(h) (increase of abundance) | FGFR3(h) --> FGFR-3-isoform1(h) (expression). | prox1(m.s.) --> FGFR-3-isoform1(h) (increase of abundance) | FGFR3(h) --> FGFR-3-isoform2(h) (expression). | FGFR3(h) --> FGFR-3-isoform3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 98 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 225 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 262 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 294 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 315 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 328 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 648 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 760 | Phosphotyrosine (FGFR3) | 11294897 | Phospho.ELM 6.0 | 770 | Phosphotyrosine (FGFR3) | 11294897 | Phospho.ELM 6.0 | 577 | Phosphotyrosine (FGFR3) | 11294897 | Phospho.ELM 6.0 | 647 | Phosphotyrosine (FGFR3) | 11294897 | Phospho.ELM 6.0 | 648 | Phosphotyrosine (FGFR3) | 11294897 | Phospho.ELM 6.0 | 724 | Phosphotyrosine (FGFR3) | 11294897 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr4 |
Promoter: 1763921 - 1765921 | Agilent_014791 |
chr4 |
Promoter: 1763921 - 1765921 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 1763921 - 1765921 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 1763921 - 1765921 | GSE27584 |
chr4 |
Promoter: 1763921 - 1765921 | GSE27584 |
chr4 |
Promoter: 1763921 - 1765921 | Agilent_014791_44K |