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Pedican
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1965

Name

EIF2S1

Synonymous

EIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2A;eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa;EIF2S1;eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Definition

eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha

Position

14q23.3

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

EIF-2alpha(h) + ATP --PKR(h)--> ADP + EIF-2alpha(h){p} (phosphorylation)
EIF2S1(h) --> EIF-2alpha(h) (expression).
EIF-2alpha(h) + ATP --> EIF-2alpha(h){p} + ADP (phosphorylation)
eIF1b(h) + EIF-2alpha(h) <==> eIF1b(h):EIF-2alpha(h) (binding)
eif5(h) + EIF-2alpha(h) <==> eif5(h):EIF-2alpha(h) (binding)
EIF-2alpha(h) + ATP --> EIF-2alpha(h){pS51} + ADP (phosphorylation)
EIF2S1(h) --> EIF-2alpha(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

49Phosphoserine (by HRI) (By similarity).Swiss-Prot 53.0
52Phosphoserine (by EIF2AK3, GCN2, HRI andPKR) (By similarity).Swiss-Prot 53.0
48Phosphoserine (HRI;EIF2AK2)3352609;16288713Phospho.ELM 6.0
51Phosphoserine (HRI;EIF2AK2)3352609;9930704;11337501Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr14

Promoter: 66895287 - 66897287GSE27584

chr14

Promoter: 66895287 - 66897287Agilent_014791_44K


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