| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 1277 |
Name | COL1A1 |
Synonymous | OI4;collagen, type I, alpha 1;COL1A1;collagen, type I, alpha 1 |
Definition | alpha-1 type I collagen|collagen alpha 1 chain type I|collagen alpha-1(I) chain|collagen of skin, tendon and bone, alpha-1 chain|pro-alpha-1 collagen type 1 |
Position | 17q21.33 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | col1A1(h) + calpain-1(h) <==> col1A1(h):calpain-1(h) (binding) | COL1A1(h) --> col1A1(h) (expression). | calcitriol --> col1A1(h) (increase of abundance) | IGFBP-5(h) --> col1A1(h) (increase of abundance) | COL1A1(h) --> COLIA1(h) (expression). | hsa-miR-29c --/ COLIA1(h) (translational repression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 162 | Pyrrolidone carboxylic acid. | Swiss-Prot 53.0 | 170 | Allysine. | Swiss-Prot 53.0 | 265 | 5-hydroxylysine. | Swiss-Prot 53.0 | 265 | O-linked (Gal...). | Swiss-Prot 53.0 | 1108 | 5-hydroxylysine (By similarity). | Swiss-Prot 53.0 | 1108 | O-linked (Gal...) (By similarity). | Swiss-Prot 53.0 | 1164 | 3-hydroxyproline (By similarity). | Swiss-Prot 53.0 | 1365 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 45633499 - 45635499 | Agilent_014791 |
chr17 |
Promoter: 45633499 - 45635499 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 45633499 - 45635499 | GSE27584 |
chr17 |
Promoter: 45633499 - 45635499 | PMID:16707423 |