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Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8651

Name

SOCS1

Synonymous

CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3;suppressor of cytokine signaling 1;SOCS1;suppressor of cytokine signaling 1

Definition

JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1

Position

16p13.13

Gene Type

protein-coding

Gene Mutation:

PCGP germline mutation
PCGP somatic mutation
COSMIC somatic mutation

PCGP germline mutation   [Top]

There is no record for SOCS1

PCGP somatic mutation   [Top]

There is no record for SOCS1

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

c.145_149delGCCCC; p.A49fs*66; 16:11256688-11256692

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; myelofibrosis

c.614G>A; p.S205N; 16:11256223-11256223

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.46G>A; p.A16T; 16:11256791-11256791

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.345T>G; p.L115L; 16:11256492-11256492

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.528G>A; p.E176E; 16:11256309-11256309

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.190T>A; p.Y64N; 16:11256647-11256647

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.236T>G; p.F79C; 16:11256601-11256601

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.240C>G; p.Y80*; 16:11256597-11256597

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.241T>A; p.W81R; 16:11256596-11256596

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.495_502delGCTGCGCC; p.L166fs*45; 16:11256335-11256342

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.630G>C; p.Q210H; 16:11256207-11256207

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.7G>A; p.A3T; 16:11256830-11256830

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.190_200del11; p.Y64fs*49; 16:11256637-11256647

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.?; p.?; 16:11256838-11256838

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.353_367del15; p.K118_P123>T; 16:11256470-11256484

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphoma

c.127C>T; p.P43S; 16:11256710-11256710

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphoma

c.347G>A; p.S116N; 16:11256490-11256490

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphoma

c.630G>C; p.Q210H; 16:11256207-11256207

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphoma

c.391C>A; p.Q131K; 16:11256446-11256446

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Burkitt_lymphoma

c.80C>T; p.S27F; 16:11256757-11256757

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; plasmacytoma

c.636+24A>G; p.?; 16:11256177-11256177

 breastcarcinoma

c.265G>A; p.A89T;

large_intestine; coloncarcinoma; adenocarcinoma

c.388_402del15; p.F130_R134del; 16:11256435-11256449

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.526_533delGAGCTGTG; p.E176fs*35; 16:11256304-11256311

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.454_464del11; p.E152fs*58; 16:11256373-11256383

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.454_464del11; p.E152fs*58; 16:11256373-11256383

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.349_359del11; p.V117fs*93; 16:11256478-11256488

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.343_349delCTTAGCG; p.L115fs*1; 16:11256488-11256494

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.208_257del50; p.S71fs*29; 16:11256580-11256629

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.193_203del11; p.R65fs*48; 16:11256634-11256644

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.526_533delGAGCTGTG; p.E176fs*35; 16:11256304-11256311

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.552_575del24; p.A184_L191del; 16:11256262-11256285

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.186_323del138; p.D63_Q108del; 16:11256514-11256651

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.318_377del60; p.R107_I126del; 16:11256460-11256519

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.471_482del12; p.P158_M161del; 16:11256355-11256366

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.236_237ins39; p.F79_Y80ins13; 16:11256600-11256601

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.192_541del350; p.Y64fs*1; 16:11256296-11256645

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.216_225del10; p.L73fs*9; 16:11256612-11256621

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.108_171del64; p.A37fs*27; 16:11256666-11256729

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.108_171del64; p.A37fs*27; 16:11256666-11256729

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.150_166del17; p.G51fs*60; 16:11256671-11256687

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.483_489delGCTGGGG; p.L162fs*41; 16:11256348-11256354

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.592C>T; p.P198S; 16:11256245-11256245

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemia

c.592C>T; p.P198S; 16:11256245-11256245

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemia_associated_with_MDS

c.203C>T; p.T68M;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia

c.348C>A; p.S116R;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.602G>A; p.R201H;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.14A>G; p.N5S;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.46G>A; p.A16T; 16:11256791-11256791

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.49G>A; p.A17T; 16:11256788-11256788

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.511_537del27; p.V171_R179del; 16:11256300-11256326

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.616T>C; p.S206P; 16:11256221-11256221

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.621C>T; p.F207F; 16:11256216-11256216

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.431_512del82; p.F144fs*34; 16:11256325-11256406

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.384G>A; p.V128V;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia

c.490delG; p.A164fs*41; 16:11256347-11256347

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia

c.191_218del28; p.Y64fs*12; 16:11256619-11256646

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.435_448>GG; p.D145_L150>EV; 16:11256389-11256402

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.349_359del11; p.V117fs*93; 16:11256478-11256488

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.393_407del15; p.Q131_H136>H; 16:11256430-11256444

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; Hodgkin_lymphoma

c.526_533delGAGCTGTG; p.E176fs*35; 16:11256304-11256311

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.552_575del24; p.A184_L191del; 16:11256262-11256285

 haematopoietic_and_lymphoid_tissue; mediastinumlymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.83C>T; p.S28F; 16:11256754-11256754

 lungcarcinoma; small_cell_carcinoma

c.99C>T; p.P33P; 16:11256738-11256738

 lungcarcinoma; small_cell_carcinoma

c.99C>T; p.P33P; 16:11256738-11256738

 lungcarcinoma; small_cell_carcinoma

c.195G>A; p.R65R; 16:11256642-11256642

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.379_636del258; p.R127_*212del; 16:11256201-11256458

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.?; p.?; 16:11256141-11256142

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.177_195del19; p.S60fs*19; 16:11256642-11256660

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.245G>A; p.G82E; 16:11256592-11256592

 central_nervous_system; brainglioma; astrocytoma_Grade_IV

c.342C>T; p.A114A;

haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemia

c.622C>T; p.P208S;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.479G>A; p.R160H;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.404T>G; p.F135C;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.360C>T; p.A120A;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.18G>C; p.Q6H;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.4G>A; p.V2I;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.7G>A; p.A3T; 16:11256830-11256830

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.46G>A; p.A16T; 16:11256791-11256791

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

c.195G>A; p.R65R; 16:11256642-11256642

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

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