| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 8626 |
Name | TP63 |
Synonymous | AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L;tumor protein p63;TP63;tumor protein p63 |
Definition | CUSP|amplified in squamous cell carcinoma|chronic ulcerative stomatitis protein|keratinocyte transcription factor KET|transformation-related protein 63|tumor protein 63|tumor protein p53-competing protein|tumor protein p63 deltaN isoform delta |
Position | 3q28 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for TP63 | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
TP63_E12_UTR_3; chr3; 189614401 |
SUB; UTR_3; A; A/G; SOMATIC | RHB; VALID; WGS |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.1555C>T; p.L519F; |
liver | carcinoma; hepatocellular_carcinoma |
c.1825G>A; p.E609K; |
skin; arm | malignant_melanoma |
c.1161G>A; p.M387I; |
skin; arm | malignant_melanoma |
c.1094C>T; p.S365L; |
skin; arm | malignant_melanoma |
c.806G>T; p.G269V; 3:191067204-191067204 |
lung | carcinoma; adenocarcinoma |
c.982G>T; p.E328*; 3:191068415-191068415 |
lung | carcinoma; adenocarcinoma |
c.510C>A; p.D170E; 3:191008940-191008940 |
lung | carcinoma; adenocarcinoma |
c.731G>T; p.C244F; 3:191064866-191064866 |
lung | carcinoma; adenocarcinoma |
c.222G>C; p.L74F; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.796C>T; p.R266*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1964G>A; p.R655Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.115A>G; p.T39A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1909C>T; p.R637C; |
pancreas | carcinoma; acinar_carcinoma |
c.1107G>C; p.K369N; |
liver | carcinoma |
c.1136G>A; p.R379H; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.1497G>T; p.M499I; 3:191087024-191087024 |
skin | malignant_melanoma |
c.1497G>T; p.M499I; 3:191087024-191087024 |
skin | malignant_melanoma |
c.1651A>G; p.S551G; |
breast | carcinoma; ductal_carcinoma |
c.1886G>A; p.G629D; |
oesophagus | carcinoma; adenocarcinoma |
c.1127G>A; p.R376H; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.378C>T; p.N126N; |
oesophagus | carcinoma; adenocarcinoma |
c.404A>G; p.N135S; |
oesophagus | carcinoma; adenocarcinoma |
c.1317A>G; p.Q439Q; |
oesophagus | carcinoma; adenocarcinoma |
c.1090G>A; p.V364I; |
lung | carcinoma; adenocarcinoma |
c.551C>T; p.S184L; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.568G>C; p.A190P; |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma |
c.242C>G; p.S81*; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.222G>C; p.L74F; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.1697C>T; p.T566M; |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma |
c.522G>T; p.P174P; |
liver | carcinoma |
c.1094C>T; p.S365L; |
skin; trunk | malignant_melanoma; nodular |
c.1616C>T; p.P539L; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia |
c.521C>A; p.P174Q; |
lung | carcinoma; adenocarcinoma |
c.637A>T; p.I213F; |
lung | carcinoma; adenocarcinoma |
c.1964G>T; p.R655L; |
lung | carcinoma; adenocarcinoma |
c.76C>G; p.P26A; |
lung | carcinoma; adenocarcinoma |
c.1309C>A; p.Q437K; |
lung | carcinoma; adenocarcinoma |
c.309G>C; p.L103L; |
lung | carcinoma; adenocarcinoma |
c.1016G>T; p.C339F; |
lung | carcinoma; adenocarcinoma |
c.1729G>C; p.E577Q; |
lung | carcinoma; adenocarcinoma |
c.1130-1G>C; p.?; |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma |
c.707A>G; p.H236R; |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma |
c.1135C>T; p.R379C; |
skin; trunk | malignant_melanoma |
c.766+1G>A; p.?; |
skin; trunk | malignant_melanoma |
c.1061C>T; p.A354V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_leukaemia |
c.1273C>T; p.Q425*; |
autonomic_ganglia | neuroblastoma |
c.193C>T; p.P65S; |
breast | carcinoma |
c.2039A>G; p.E680G; |
liver | carcinoma |
c.432G>T; p.T144T; |
lung | carcinoma; small_cell_carcinoma |
c.677G>A; p.R226H; |
prostate | adenoma |
c.274A>C; p.S92R; |
autonomic_ganglia | neuroblastoma |
c.14C>T; p.T5I; |
lung | carcinoma; adenocarcinoma |
c.319A>T; p.M107L; 3:190939252-190939252 |
ovary | carcinoma; serous_carcinoma |
c.1163C>T; p.T388I; |
lung | carcinoma; squamous_cell_carcinoma |
c.1928G>A; p.R643Q; |
ovary | carcinoma; serous_carcinoma |
c.1227G>C; p.E409D; |
lung | carcinoma; squamous_cell_carcinoma |
c.468C>T; p.F156F; |
lung | carcinoma; squamous_cell_carcinoma |
c.1885G>T; p.G629C; |
lung | carcinoma; adenocarcinoma |
c.1257G>A; p.E419E; |
lung | carcinoma; adenocarcinoma |
c.455C>A; p.P152H; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.985A>C; p.T329P; 3:191068418-191068418 |
ovary | carcinoma; serous_carcinoma |
c.551C>G; p.S184W; |
lung | carcinoma; squamous_cell_carcinoma |
c.1971G>T; p.E657D; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.516A>G; p.P172P; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.157G>C; p.E53Q; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1713C>T; p.T571T; |
breast | carcinoma |
c.60G>A; p.Q20Q; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1581C>G; p.P527P; |
endometrium | carcinoma; endometrioid_carcinoma |
c.522G>A; p.P174P; |
endometrium | carcinoma; endometrioid_carcinoma |
c.807G>A; p.G269G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.762C>T; p.N254N; |
breast | carcinoma |
c.447C>T; p.Y149Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.796C>T; p.R266*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.336G>A; p.T112T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.415G>A; p.A139T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.987C>T; p.T329T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1129C>T; p.P377S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1028G>A; p.R343Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.752G>A; p.R251H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1110C>T; p.N370N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1485T>G; p.I495M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.531C>T; p.F177F; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2007_2008CA>AT; p.R669>?; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1780C>T; p.R594*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.302C>T; p.S101L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.522G>A; p.P174P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.453G>A; p.Q151Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.829G>T; p.E277*; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.142G>T; p.E48*; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1909C>T; p.R637C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.66C>T; p.F22F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1013G>A; p.R338H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1083G>A; p.K361K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1780C>T; p.R594*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.431C>T; p.T144M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1129+1G>A; p.?; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1253A>G; p.K418R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1657T>C; p.L553L; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.335C>T; p.T112M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1010G>T; p.R337L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1173G>T; p.K391N; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1780C>T; p.R594*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1465G>A; p.A489T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1787C>T; p.A596V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1458G>A; p.Q486Q; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1107G>C; p.K369N; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1748A>T; p.D583V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.469G>T; p.D157Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.796C>T; p.R266*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.448G>A; p.A150T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.983A>G; p.E328G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.319A>G; p.M107V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.521C>T; p.P174L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.72A>G; p.E24E; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.66C>T; p.F22F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.110G>A; p.R37Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.453G>A; p.Q151Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1128C>T; p.R376R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1788G>A; p.A596A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.46G>A; p.D16N; |
urinary_tract; bladder | carcinoma |
c.1010G>A; p.R337Q; |
urinary_tract; bladder | carcinoma |
c.399C>T; p.P133P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.985A>G; p.T329A; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1094C>T; p.S365L; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.569C>T; p.A190V; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.434C>T; p.A145V; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.142G>A; p.E48K; |
urinary_tract; bladder | carcinoma |
c.987C>A; p.T329T; |
cervix | carcinoma; squamous_cell_carcinoma |
c.731G>A; p.C244Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.379G>A; p.G127S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1993A>G; p.M665V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.321G>A; p.M107I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.806G>A; p.G269E; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.173T>C; p.I58T; |
urinary_tract; bladder | carcinoma |
c.1964G>A; p.R655Q; |
skin | malignant_melanoma |
c.700G>A; p.A234T; |
skin | malignant_melanoma |
c.1825G>A; p.E609K; |
skin | malignant_melanoma |
c.1969G>A; p.E657K; |
skin | malignant_melanoma |
c.50C>T; p.P17L; |
skin | malignant_melanoma |
c.1934_1935CC>TT; p.T645I; |
skin | malignant_melanoma |
c.532G>A; p.D178N; |
skin | malignant_melanoma |
c.1973G>A; p.W658*; |
skin | malignant_melanoma |
c.1576C>T; p.P526S; |
skin | malignant_melanoma |
c.1679C>T; p.S560L; |
skin | malignant_melanoma |
c.579+1G>A; p.?; |
skin | malignant_melanoma |
c.648G>A; p.M216I; |
skin | malignant_melanoma |
c.1416G>A; p.M472I; |
skin | malignant_melanoma |
c.1747G>A; p.D583N; |
skin | malignant_melanoma |
c.1995G>A; p.M665I; |
skin | malignant_melanoma |
c.1135C>T; p.R379C; |
skin | malignant_melanoma |
c.1094C>T; p.S365L; |
skin; mucosal | malignant_melanoma |
c.397C>T; p.P133S; |
skin; face | carcinoma; squamous_cell_carcinoma |