| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 6416 |
Name | MAP2K4 |
Synonymous | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1;mitogen-activated protein kinase kinase 4;MAP2K4;mitogen-activated protein kinase kinase 4 |
Definition | JNK activating kinase 1|JNK-activated kinase 1|JNK-activating kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|MAPKK 4|MEK 4|SAPK kinase 1|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4|stress-a |
Position | 17p11.2 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for MAP2K4 | ||
PCGP somatic mutation [Top] | ||
There is no record for MAP2K4 | ||
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.745G>C; p.G249R; |
large_intestine | carcinoma; adenocarcinoma |
c.253G>A; p.G85R; |
lung | carcinoma; squamous_cell_carcinoma |
c.401G>A; p.R134Q; 17:11939624-11939624 |
large_intestine | carcinoma; adenocarcinoma |
c.774T>C; p.I258I; 17:11957363-11957363 |
large_intestine | carcinoma; adenocarcinoma |
c.961G>A; p.V321M; 17:11973250-11973250 |
large_intestine | carcinoma; adenocarcinoma |
c.977C>T; p.P326L; 17:11973266-11973266 |
large_intestine | carcinoma; adenocarcinoma |
c.1200+92G>A; p.?; 17:11985371-11985371 |
large_intestine | carcinoma; adenocarcinoma |
c.513+2T>C; p.?; |
breast | carcinoma; lobular_carcinoma |
c.752G>A; p.S251N; 17:11957341-11957341 |
salivary_gland | carcinoma; myoepithelial_carcinoma |
c.219-1G>C; p.?; 17:11925397-11925397 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.421G>T; p.E141*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.451G>T; p.V151L; |
pancreas | carcinoma |
c.841C>T; p.R281*; |
pancreas | carcinoma |
c.683G>A; p.R228K; |
breast | carcinoma; ER-PR-positive_carcinoma |
c.979C>T; p.Q327*; |
pancreas | carcinoma; acinar_carcinoma |
c.1-?_393+?del; p.?; |
pancreas | carcinoma; ductal_carcinoma |
c.661G>T; p.E221*; 17:11954444-11954444 |
pancreas | carcinoma; ductal_carcinoma |
c.661G>T; p.E221*; 17:11954444-11954444 |
pancreas | carcinoma; adenocarcinoma |
c.835G>A; p.A279T; 17:11969357-11969357 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
breast | carcinoma; luminal_NS_carcinoma |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
breast | carcinoma |
c.742T>G; p.F248V; |
oesophagus | carcinoma; adenocarcinoma |
c.1041-1G>A; p.?; |
oesophagus | carcinoma; adenocarcinoma |
c.677T>G; p.I226S; |
oesophagus | carcinoma; adenocarcinoma |
c.400C>T; p.R134W; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.460C>T; p.R154W; 17:11939683-11939683 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1023C>G; p.I341M; |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
ovary | carcinoma; serous_carcinoma |
c.?_?del?; p.E74fs*?; |
ovary | carcinoma; endometrioid_carcinoma |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
ovary | carcinoma; serous_carcinoma |
c.?_?del?; p.D263fs*?; |
ovary | carcinoma; serous_carcinoma |
c.451G>T; p.V151L; |
pancreas | carcinoma; ductal_carcinoma |
c.841C>T; p.R281*; |
pancreas | carcinoma; ductal_carcinoma |
c.966A>C; p.K322N; |
lung | carcinoma; adenocarcinoma |
c.668_669insT; p.L223fs*22; |
lung | carcinoma; adenocarcinoma |
c.1069A>C; p.K357Q; |
lung | carcinoma; adenocarcinoma |
c.1119T>A; p.R373R; |
lung | carcinoma; adenocarcinoma |
c.551C>T; p.S184L; 17:11951869-11951869 |
breast | carcinoma |
c.551C>T; p.S184L; 17:11951869-11951869 |
breast | carcinoma; luminal_NS_carcinoma |
c.839C>A; p.S280*; 17:11969361-11969361 |
breast | carcinoma |
c.839C>A; p.S280*; 17:11969361-11969361 |
breast | carcinoma; luminal_NS_carcinoma |
c.219-1G>C; p.?; 17:11925397-11925397 |
breast | carcinoma |
c.219-1G>C; p.?; 17:11925397-11925397 |
breast | carcinoma; luminal_NS_carcinoma |
c.752G>A; p.S251N; 17:11957341-11957341 |
skin | malignant_melanoma |
c.927G>C; p.K309N; 17:11973216-11973216 |
testis | germ_cell_tumour |
c.219-?_1200+?del; p.?; |
lung | carcinoma |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
ovary | carcinoma; serous_carcinoma |
c.908G>T; p.G303V; |
pancreas | carcinoma; ductal_carcinoma |
c.908G>T; p.G303V; |
NS | NS |
c.882delG; p.I295fs*23; 17:11969404-11969404 |
lung | carcinoma; large_cell_carcinoma |
c.425A>T; p.Q142L; 17:11939648-11939648 |
lung | carcinoma; squamous_cell_carcinoma |
c.701A>T; p.N234I; 17:11957290-11957290 |
ovary | carcinoma; serous_carcinoma |
c.460C>T; p.R154W; 17:11939683-11939683 |
large_intestine | carcinoma; adenocarcinoma |
c.929G>A; p.W310*; 17:11973218-11973218 |
large_intestine | carcinoma; adenocarcinoma |
c.835G>A; p.A279T; 17:11969357-11969357 |
large_intestine | carcinoma; adenocarcinoma |
c.910C>T; p.R304*; 17:11973199-11973199 |
large_intestine | carcinoma; adenocarcinoma |
c.444delT; p.L149fs*3; |
breast | carcinoma |
c.697T>G; p.S233A; |
breast | carcinoma |
c.219-2_219-1delag; p.?; |
breast | carcinoma |
c.551C>T; p.S184L; 17:11951869-11951869 |
breast | carcinoma |
c.1038_1039insAACTTG; p.L346_C347insNL; |
breast | carcinoma |
c.251C>G; p.S84*; |
breast | carcinoma |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
biliary_tract; bile_duct | carcinoma; adenocarcinoma |
c.1-?_115+?del; p.?; |
pancreas | carcinoma; ductal_carcinoma |
c.1_1200del1200; p.0?; 17:11864929-11985302 |
pancreas | carcinoma; ductal_carcinoma |
c.820A>G; p.R274G; 17:11969342-11969342 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1167A>T; p.P389P; |
lung | carcinoma; squamous_cell_carcinoma |
c.328C>T; p.R110*; 17:11925507-11925507 |
ovary | carcinoma; serous_carcinoma |
c.997G>T; p.E333*; |
lung | carcinoma; adenocarcinoma |
c.746G>T; p.G249V; |
ovary | carcinoma; serous_carcinoma |
c.1166C>T; p.P389L; |
lung | carcinoma; adenocarcinoma |
c.368C>A; p.P123Q; |
lung | carcinoma; squamous_cell_carcinoma |
c.891+1G>C; p.?; |
lung | carcinoma; adenocarcinoma |
c.793G>T; p.G265C; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.686-1G>A; p.?; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.952_953delAC; p.Q319fs*11; |
breast | carcinoma |
c.752G>T; p.S251I; |
breast | carcinoma |
c.237C>T; p.H79H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.840A>G; p.S280S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.978G>C; p.P326P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.820A>G; p.R274G; 17:11969342-11969342 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.589G>T; p.D197Y; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1154T>C; p.L385P; |
breast | carcinoma |
c.495T>A; p.Y165*; |
breast | carcinoma |
c.817G>A; p.E273K; |
breast | carcinoma |
c.599T>C; p.I200T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.873G>T; p.W291C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.663A>G; p.E221E; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.287A>T; p.D96V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.871T>C; p.W291R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.296C>T; p.A99V; |
large_intestine; colon | NS |
c.644C>G; p.A215G; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.917C>A; p.P306H; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.860G>A; p.R287H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.754G>A; p.G252R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.817G>T; p.E273*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.421G>A; p.E141K; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.860G>A; p.R287H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.219-2_219-1delag; p.?; |
breast | carcinoma |
c.656T>C; p.L219S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.400C>T; p.R134W; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.373G>A; p.G125R; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.400C>T; p.R134W; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.960C>T; p.V320V; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.814-1G>T; p.?; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.473_474insC; p.Y160fs*14; |
breast | carcinoma |
c.515_516insT; p.D173fs*1; |
breast | carcinoma |
c.1153C>G; p.L385V; |
breast | carcinoma |
c.811G>A; p.A271T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1092T>C; p.H364H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.310G>T; p.D104Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.770C>T; p.S257F; |
breast | carcinoma |
c.1006_1007insTC; p.S339fs*25; |
breast | carcinoma |
c.976C>T; p.P326S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.839C>A; p.S280*; 17:11969361-11969361 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.330A>G; p.R110R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.401G>T; p.R134L; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.978G>A; p.P326P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1132G>A; p.A378T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.814-1G>A; p.?; |
endometrium | carcinoma; endometrioid_carcinoma |
c.218+1_218+2insT; p.?; |
breast | carcinoma |
c.783_784delAA; p.D263fs*4; |
breast | carcinoma |
c.633+1_633+2insT; p.?; |
breast | carcinoma |
c.793_799delGGCTGTA; p.C266fs*8; |
breast | carcinoma |
c.1086+1G>A; p.?; |
breast | carcinoma |
c.551C>T; p.S184L; 17:11951869-11951869 |
breast | carcinoma |
c.400C>T; p.R134W; |
breast | carcinoma |
c.551C>T; p.S184L; 17:11951869-11951869 |
breast | carcinoma |
c.557A>G; p.D186G; |
breast | carcinoma |
c.868G>T; p.V290F; |
breast | carcinoma |
c.891+2T>C; p.?; |
breast | carcinoma |
c.946C>T; p.Q316*; |
breast | carcinoma |
c.1087-1G>C; p.?; |
breast | carcinoma |
c.752G>T; p.S251I; |
breast | carcinoma |
c.328C>T; p.R110*; 17:11925507-11925507 |
endometrium | carcinoma; endometrioid_carcinoma |
c.842G>A; p.R281Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1046C>T; p.T349M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.619A>T; p.K207*; |
breast | carcinoma |
c.928T>C; p.W310R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.607G>T; p.E203*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.962T>C; p.V321A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.373G>A; p.G125R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.835G>T; p.A279S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.634-1G>A; p.?; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.330A>G; p.R110R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.977C>T; p.P326L; 17:11973266-11973266 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1091A>C; p.H364P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.978G>A; p.P326P; |
endometrium | carcinoma; endometrioid_carcinoma |
c.569_591del23; p.K190fs*47; |
endometrium | carcinoma; endometrioid_carcinoma |
c.409G>A; p.V137M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.330A>G; p.R110R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.239G>A; p.S80N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.978G>A; p.P326P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.836C>A; p.A279E; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.917C>G; p.P306R; |
breast | carcinoma |
c.836C>T; p.A279V; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1041-2A>G; p.?; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.386_393+9del17; p.?; |
breast | carcinoma |
c.219-2_219-1delag; p.?; |
breast | carcinoma |
c.895G>T; p.E299*; |
breast | carcinoma |
c.335_336insT; p.Y113fs*19; |
breast | carcinoma |
c.962T>A; p.V321E; |
prostate | carcinoma; adenocarcinoma |
c.783_784delAA; p.D263fs*4; |
breast | carcinoma |
c.929G>T; p.W310L; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.977C>T; p.P326L; 17:11973266-11973266 |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.335C>T; p.A112V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia |
c.374G>T; p.G125V; 17:11925553-11925553 |
stomach | carcinoma |
c.1043T>G; p.L348R; |
biliary_tract; bile_duct | carcinoma; adenocarcinoma |
c.328C>T; p.R110*; 17:11925507-11925507 |
stomach | carcinoma |
c.714C>A; p.D238E; |
skin | malignant_melanoma |
c.155C>T; p.P52L; |
skin | malignant_melanoma |
c.400C>T; p.R134W; |
skin; scalp | carcinoma; squamous_cell_carcinoma |
c.829C>T; p.P277S; |
skin; scalp | carcinoma; squamous_cell_carcinoma |