| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 5594 |
Name | MAPK1 |
Synonymous | ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk;mitogen-activated protein kinase 1;MAPK1;mitogen-activated protein kinase 1 |
Definition | ERK-2|MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|p42-MAPK|protein tyrosine kinase ERK2 |
Position | 22q11.2|22q11.21 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for MAPK1 | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
MAPK1_V173I; chr22; 22153393 |
SUB; MISSENSE; C; C/T; SOMATIC | HYPO; VALID; EXOME |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.961G>A; p.D321N; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.730C>A; p.L244I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.120-10_120-9delct; p.?; |
NS | malignant_melanoma |
c.188C>T; p.T63I; |
skin; abdomen | malignant_melanoma |
c.947A>T; p.Y316F; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.872A>G; p.D291G; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.484G>A; p.D162N; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.737C>T; p.S246F; |
oesophagus | carcinoma; adenocarcinoma |
c.964G>A; p.E322K; |
oesophagus | carcinoma; squamous_cell_carcinoma |
c.965A>T; p.E322V; |
liver | carcinoma |
c.572G>A; p.R191H; |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma |
c.600G>T; p.L200F; |
pancreas | carcinoma; ductal_carcinoma |
c.600G>T; p.L200F; |
NS | NS |
c.868T>C; p.L290L; |
breast | carcinoma |
c.1053T>G; p.T351T; |
liver | carcinoma |
c.485A>G; p.D162G; |
lung | carcinoma; squamous_cell_carcinoma |
c.429T>A; p.A143A; 22:20490202-20490202 |
ovary | carcinoma; serous_carcinoma |
c.471C>A; p.L157L; |
lung | carcinoma; squamous_cell_carcinoma |
c.837C>T; p.F279F; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.471C>G; p.L157L; |
ovary | carcinoma; serous_carcinoma |
c.704A>T; p.D235V; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.154G>T; p.A52S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.785A>C; p.N262T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.515G>A; p.R172H; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.361C>A; p.L121I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1033G>T; p.E345*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.781A>G; p.R261G; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.241G>A; p.E81K; |
breast | carcinoma |
c.892C>A; p.P298T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.548T>C; p.F183S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.285C>T; p.I95I; |
urinary_tract; bladder | carcinoma |
c.964G>A; p.E322K; |
cervix | carcinoma; squamous_cell_carcinoma |
c.429T>C; p.A143A; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.428C>A; p.A143D; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.962A>T; p.D321V; |
skin | malignant_melanoma |
c.797C>T; p.S266F; |
skin | malignant_melanoma |
c.803C>T; p.P268L; |
skin; mucosal | malignant_melanoma |
c.685C>T; p.P229S; |
skin; scalp | carcinoma; squamous_cell_carcinoma |