Pediatric cancer gene database (Pedican) Home
Pedican
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4683

Name

NBN

Synonymous

AT-V1|AT-V2|ATV|NBS|NBS1|P95;nibrin;NBN;nibrin

Definition

Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex

Position

8q21

Gene Type

protein-coding

Gene Mutation:

PCGP germline mutation
PCGP somatic mutation
COSMIC somatic mutation

PCGP germline mutation   [Top]

There is no record for NBN

PCGP somatic mutation   [Top]

There is no record for NBN

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

c.904C>A; p.L302I;

large_intestine; coloncarcinoma; adenocarcinoma

c.1535A>G; p.E512G;

lungcarcinoma; undifferentiated_carcinoma

c.425A>G; p.N142S;

oesophaguscarcinoma; adenocarcinoma

c.1036G>A; p.V346M;

oesophaguscarcinoma; adenocarcinoma

c.1497A>G; p.S499S;

oesophaguscarcinoma; adenocarcinoma

c.1398-10delt; p.?;

oesophaguscarcinoma; adenocarcinoma

c.128G>A; p.R43Q;

oesophaguscarcinoma; adenocarcinoma

c.671G>C; p.G224A;

lungcarcinoma; large_cell_carcinoma

c.1681G>A; p.E561K;

lungcarcinoma; non_small_cell_carcinoma

c.1066G>A; p.A356T;

lungcarcinoma; non_small_cell_carcinoma

c.459A>G; p.V153V;

livercarcinoma

c.724G>C; p.V242L;

livercarcinoma

c.705T>G; p.H235Q;

livercarcinoma

c.2128G>T; p.A710S;

large_intestine; coloncarcinoma

c.50G>C; p.R17T;

upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinoma

c.1131G>C; p.L377F;

upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinoma

c.1454C>T; p.T485M;

upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinoma

c.2052T>A; p.N684K;

lungcarcinoma; adenocarcinoma

c.308delG; p.G103fs*6;

lungcarcinoma; adenocarcinoma

c.1052A>G; p.K351R;

lungcarcinoma; adenocarcinoma

c.366C>G; p.V122V;

lungcarcinoma; adenocarcinoma

c.1253C>G; p.S418*;

lungcarcinoma; adenocarcinoma

c.1936G>T; p.D646Y;

lungcarcinoma; adenocarcinoma

c.1471G>T; p.E491*;

skin; extremitymalignant_melanoma

c.585T>A; p.S195R;

autonomic_ganglianeuroblastoma

c.671G>C; p.G224A;

lungcarcinoma; large_cell_carcinoma

c.1115C>T; p.A372V;

pancreascarcinoma; ductal_carcinoma

c.373_378>C; p.K125fs*34; 8:91062240-91062245

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.2035T>C; p.Y679H;

kidneycarcinoma

c.2192delA; p.N731fs*20; 8:91018472-91018472

kidneycarcinoma

c.1089C>T; p.Y363Y;

prostatecarcinoma

c.1992T>G; p.I664M;

lungcarcinoma; small_cell_carcinoma

c.244A>G; p.K82E;

prostateadenoma

c.504A>G; p.G168G; 8:91059704-91059704

central_nervous_system; brainglioma; astrocytoma_Grade_IV

c.2242C>T; p.P748S; 8:91017009-91017009

central_nervous_system; brainglioma; astrocytoma_Grade_IV

c.1296A>G; p.S432S; 8:91036788-91036788

central_nervous_system; brainglioma; astrocytoma_Grade_IV

c.123C>T; p.I41I;

ovarycarcinoma; serous_carcinoma

c.814G>A; p.D272N;

ovarycarcinoma; serous_carcinoma

c.22G>A; p.A8T;

lungcarcinoma; squamous_cell_carcinoma

c.1013C>T; p.P338L;

lung; right_lower_lobecarcinoma; adenocarcinoma

c.162A>T; p.V54V;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.850G>C; p.D284H;

lungcarcinoma; adenocarcinoma

c.2185G>C; p.V729L;

lungcarcinoma; adenocarcinoma

c.1980A>G; p.R660R;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.1458T>C; p.S486S;

lungcarcinoma; squamous_cell_carcinoma

c.666C>T; p.F222F;

lung; right_lower_lobecarcinoma; adenocarcinoma

c.1296A>G; p.S432S; 8:91036788-91036788

large_intestine; coloncarcinoma; adenocarcinoma

c.504A>G; p.G168G; 8:91059704-91059704

large_intestine; coloncarcinoma; adenocarcinoma

c.1296A>G; p.S432S; 8:91036788-91036788

large_intestine; coloncarcinoma; adenocarcinoma

c.1651delA; p.R551fs*8;

large_intestine; coloncarcinoma; adenocarcinoma

c.1651delA; p.R551fs*8;

large_intestine; caecumcarcinoma; adenocarcinoma

c.1911A>G; p.I637M;

large_intestine; coloncarcinoma; adenocarcinoma

c.2062T>G; p.F688V;

large_intestine; rectumcarcinoma; adenocarcinoma

c.1060C>T; p.P354S;

endometriumcarcinoma; endometrioid_carcinoma

c.803C>T; p.T268M;

endometriumcarcinoma; endometrioid_carcinoma

c.1627G>A; p.E543K;

endometriumcarcinoma; endometrioid_carcinoma

c.1906G>T; p.E636*;

endometriumcarcinoma; endometrioid_carcinoma

c.1340C>A; p.S447Y;

endometriumcarcinoma; endometrioid_carcinoma

c.16C>T; p.P6S;

endometriumcarcinoma; endometrioid_carcinoma

c.2053T>G; p.F685V;

endometriumcarcinoma; endometrioid_carcinoma

c.128G>A; p.R43Q;

endometriumcarcinoma; endometrioid_carcinoma

c.1577C>T; p.T526I;

endometriumcarcinoma; endometrioid_carcinoma

c.653G>T; p.R218I;

endometriumcarcinoma; endometrioid_carcinoma

c.1870C>T; p.R624C;

endometriumcarcinoma; endometrioid_carcinoma

c.965A>G; p.Y322C;

large_intestine; coloncarcinoma; adenocarcinoma

c.2141G>T; p.R714L;

prostatecarcinoma; adenocarcinoma

c.1294T>C; p.S432P;

large_intestine; coloncarcinoma; adenocarcinoma

c.1958_1959insA; p.L654fs*5;

large_intestine; coloncarcinoma; adenocarcinoma

c.1396delA; p.R466fs*18;

large_intestine; coloncarcinoma; adenocarcinoma

c.504A>G; p.G168G; 8:91059704-91059704

large_intestine; coloncarcinoma; adenocarcinoma

c.1253C>A; p.S418*;

endometriumcarcinoma; endometrioid_carcinoma

c.851A>G; p.D284G;

endometriumcarcinoma; endometrioid_carcinoma

c.2219C>T; p.A740V;

endometriumcarcinoma; endometrioid_carcinoma

c.504A>G; p.G168G; 8:91059704-91059704

large_intestine; rectumcarcinoma; adenocarcinoma

c.2134C>T; p.H712Y;

urinary_tract; bladdercarcinoma

c.325G>A; p.E109K;

urinary_tract; bladdercarcinoma

c.504A>G; p.G168G; 8:91059704-91059704

large_intestine; coloncarcinoma; adenocarcinoma

c.979G>T; p.G327C;

large_intestine; rectumcarcinoma; adenocarcinoma

c.1982C>A; p.S661*;

large_intestine; rectumcarcinoma; adenocarcinoma

c.503G>T; p.G168V;

large_intestine; rectumcarcinoma; adenocarcinoma

c.107A>C; p.E36A;

urinary_tract; bladdercarcinoma

c.393T>C; p.A131A;

large_intestine; coloncarcinoma; adenocarcinoma

c.1296A>G; p.S432S; 8:91036788-91036788

large_intestine; coloncarcinoma; adenocarcinoma

c.580G>A; p.E194K;

urinary_tract; bladdercarcinoma

c.266G>A; p.R89Q;

urinary_tract; bladdercarcinoma

c.557C>T; p.S186F;

skin; mucosalmalignant_melanoma


')