| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4609 |
Name | MYC |
Synonymous | MRTL|bHLHe39|c-Myc;v-myc myelocytomatosis viral oncogene homolog (avian);MYC;v-myc myelocytomatosis viral oncogene homolog (avian) |
Definition | avian myelocytomatosis viral oncogene homolog|class E basic helix-loop-helix protein 39|myc proto-oncogene protein|myc-related translation/localization regulatory factor|proto-oncogene c-Myc|transcription factor p64|v-myc avian myelocytomatosis viral onco |
Position | 8q24.21 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for MYC | ||
PCGP somatic mutation [Top] | ||
There is no record for MYC | ||
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.1041C>T; p.S347S; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.40C>G; p.L14V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.661G>A; p.D221N; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.117G>C; p.E39D; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.413T>C; p.F138S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.460G>A; p.A154T; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.701_703delGCC; p.S234_P235>T; 8:128820391-128820393 |
lung | carcinoma; adenocarcinoma |
c.749G>T; p.S250I; 8:128820439-128820439 |
lung | carcinoma; adenocarcinoma |
c.421G>A; p.A141T; |
pancreas | carcinoid-endocrine_tumour; islet_cell |
c.413T>C; p.F138S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.117G>C; p.E39D; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.524G>C; p.S175T; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.227C>T; p.A76V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.413T>C; p.F138S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.8T>G; p.L3R; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.608G>C; p.S203T; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.1140G>A; p.Q380Q; |
lung | carcinoma; adenocarcinoma |
c.975C>G; p.V325V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; plasma_cell_myeloma |
c.996C>T; p.V332V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; plasma_cell_myeloma |
c.997C>G; p.L333V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; plasma_cell_myeloma |
c.75C>G; p.C25W; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.76G>A; p.D26N; |
liver | carcinoma |
c.13G>A; p.V5I; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.343T>C; p.F115L; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.420C>A; p.A140A; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.117G>A; p.E39E; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.586C>T; p.P196S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |
c.413T>C; p.F138S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.1213T>A; p.S405T; |
oesophagus | carcinoma; adenocarcinoma |
c.172A>C; p.T58P; |
oesophagus | carcinoma; adenocarcinoma |
c.758-3A>C; p.?; |
liver | carcinoma; hepatocellular_carcinoma |
c.176C>T; p.P59L; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.35A>C; p.Y12S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.294G>C; p.Q98H; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.599A>T; p.N200I; |
lung | carcinoma; adenocarcinoma |
c.1317G>T; p.A439A; |
lung | carcinoma; adenocarcinoma |
c.172A>C; p.T58P; |
lung | carcinoma; adenocarcinoma |
c.746G>A; p.S249N; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |
c.341G>C; p.S114T; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |
c.430C>G; p.L144V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |
c.99G>C; p.Q33H; |
skin; trunk | malignant_melanoma |
c.173C>T; p.T58I; |
autonomic_ganglia | neuroblastoma |
c.14T>C; p.V5A; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.172A>G; p.T58A; |
pancreas | carcinoma; ductal_carcinoma |
c.17G>C; p.S6T; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.117G>C; p.E39D; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.131C>T; p.A44V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.1169delC; p.K392fs*2; |
lung | carcinoma; small_cell_carcinoma |
c.130G>A; p.A44T; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |
c.948G>A; p.R316R; 8:128822014-128822014 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.1085T>C; p.L362S; |
ovary | carcinoma; serous_carcinoma |
c.1140G>C; p.Q380H; |
ovary | carcinoma; serous_carcinoma |
c.648C>T; p.F216F; 8:128820338-128820338 |
ovary | carcinoma; serous_carcinoma |
c.231C>G; p.V77V; |
lung | carcinoma; squamous_cell_carcinoma |
c.916C>G; p.Q306E; |
lung | carcinoma; squamous_cell_carcinoma |
c.153G>T; p.K51N; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.437C>T; p.S146L; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.789_791delTGT; p.V265delV; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.425C>T; p.A142V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.263G>A; p.G88D; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.176C>T; p.P59L; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.1210C>A; p.L404M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.848C>A; p.S283Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1076A>G; p.H359R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.227C>T; p.A76V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1061T>A; p.V354D; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1122T>A; p.F374L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.153G>A; p.K51K; |
urinary_tract; bladder | carcinoma |
c.900C>T; p.C300C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.974T>A; p.V325D; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1246G>A; p.E416K; |
breast | carcinoma |
c.947G>T; p.R316L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.21C>G; p.F7L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.90C>T; p.N30N; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.413T>G; p.F138C; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.35A>G; p.Y12C; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.46T>C; p.Y16H; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.144_258115>T; p.I49_N86del38; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.175C>T; p.P59S; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.102G>C; p.Q34H; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.104A>T; p.Q35L; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.105G>A; p.Q35Q; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.528G>A; p.L176L; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |
c.746G>A; p.S249N; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; Burkitt_lymphoma |