| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3791 |
Name | KDR |
Synonymous | CD309|FLK1|VEGFR|VEGFR2;kinase insert domain receptor (a type III receptor tyrosine kinase);KDR;kinase insert domain receptor (a type III receptor tyrosine kinase) |
Definition | fetal liver kinase 1|fetal liver kinase-1|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2 |
Position | 4q11-q12 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
CBL | NCI_NATURE; |
in same component |
CDH5 | NCI_NATURE; |
in same component |
CTNNA1 | NCI_NATURE; |
in same component |
CTNNB1 | NCI_NATURE; |
in same component |
DNM2 | NCI_NATURE; |
in same component |
FIGF | NCI_NATURE; |
in same component |
FLT1 | NCI_NATURE; |
in same component |
FLT4 | NCI_NATURE; |
in same component |
FYN | NCI_NATURE; |
in same component |
HSP90AA1 | NCI_NATURE; |
in same component |
IQGAP1 | NCI_NATURE; |
in same component |
ITGAV | NCI_NATURE; |
in same component |
ITGB3 | NCI_NATURE; |
in same component |
MYOF | NCI_NATURE; |
in same component |
NRP1 | NCI_NATURE; |
in same component |
NRP2 | NCI_NATURE; |
in same component |
PAK2 | NCI_NATURE; |
in same component |
RHOA | NCI_NATURE; |
in same component |
ROCK1 | NCI_NATURE; |
in same component |
SH2D2A | NCI_NATURE; |
in same component |
SHB | NCI_NATURE; |
in same component |
SRC | NCI_NATURE; |
in same component |
VEGFA | NCI_NATURE; |
in same component |
VEGFC | NCI_NATURE; |
in same component |
VTN | NCI_NATURE; |
interacts with |
ACP1 | BIOGRID; |
interacts with |
ANXA5 | BIOGRID; |
interacts with |
ANXA5 | HPRD; |
interacts with |
ATR | HPRD; |
interacts with |
BMX | HPRD; |
interacts with |
CAV1 | HPRD; |
interacts with |
CBL | BIOGRID; |
interacts with |
CBL | HPRD; |
interacts with |
CDH5 | BIOGRID; |
interacts with |
CDH5 | HPRD; |
interacts with |
CDH5 | MINT; |
interacts with |
COL18A1 | BIOGRID; |
interacts with |
COL18A1 | HPRD; |
interacts with |
CRK | HPRD; |
interacts with |
CSF2RB | HPRD; |
interacts with |
CTNNB1 | HPRD; |
interacts with |
FIGF | BIOGRID; |
interacts with |
FIGF | HPRD; |
interacts with |
FLT1 | BIOGRID; |
interacts with |
FLT4 | HPRD; |
interacts with |
FLT4 | INTACT; |
interacts with |
FLT4 | MINT; |
interacts with |
FRS2 | HPRD; |
interacts with |
FYN | HPRD; |
interacts with |
FYN | MINT; |
interacts with |
GNA11 | HPRD; |
interacts with |
GNAQ | HPRD; |
interacts with |
GRB10 | BIOGRID; |
interacts with |
GRB10 | HPRD; |
interacts with |
HSP90AA1 | HPRD; |
interacts with |
IQGAP1 | HPRD; |
interacts with |
ITGB3 | HPRD; |
interacts with |
NCK1 | HPRD; |
interacts with |
NCK1 | MINT; |
interacts with |
NRP1 | MINT; |
interacts with |
P2RY2 | HPRD; |
interacts with |
PLCG1 | BIOGRID; |
interacts with |
PLCG1 | MINT; |
interacts with |
PLCG2 | HPRD; |
interacts with |
PLXNA1 | BIOGRID; |
interacts with |
PTPN11 | HPRD; |
interacts with |
PTPN6 | HPRD; |
interacts with |
RASA1 | BIOGRID; |
interacts with |
RASA1 | HPRD; |
interacts with |
SHB | BIOGRID; |
interacts with |
SHB | HPRD; |
interacts with |
SHB | MINT; |
interacts with |
SHC1 | BIOGRID; |
interacts with |
SHC1 | HPRD; |
interacts with |
SHC1 | MINT; |
interacts with |
SHC2 | BIOGRID; |
interacts with |
SHC2 | HPRD; |
interacts with |
SHC2 | MINT; |
interacts with |
SRC | HPRD; |
interacts with |
STAT1 | HPRD; |
interacts with |
SYNGAP1 | HPRD; |
interacts with |
TIMP3 | HPRD; |
interacts with |
VEGFA | BIOGRID; |
interacts with |
VEGFA | HPRD; |
interacts with |
VEGFA | MINT; |
interacts with |
VEGFC | HPRD; |
interacts with |
YES1 | HPRD; |
Metabolic Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
metabolic catalysis |
ARNT | NCI_NATURE; |
metabolic catalysis |
EPAS1 | NCI_NATURE; |
metabolic catalysis |
ETS1 | NCI_NATURE; |
metabolic catalysis |
HEY1 | NCI_NATURE; |
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
CBL | NCI_NATURE; |
reacts with |
CDH5 | NCI_NATURE; |
reacts with |
CTNNA1 | NCI_NATURE; |
reacts with |
CTNNB1 | NCI_NATURE; |
reacts with |
DNM2 | NCI_NATURE; |
reacts with |
FIGF | NCI_NATURE; |
reacts with |
FLT1 | NCI_NATURE; |
reacts with |
FLT4 | NCI_NATURE; |
reacts with |
FYN | NCI_NATURE; |
reacts with |
HSP90AA1 | NCI_NATURE; |
reacts with |
IQGAP1 | NCI_NATURE; |
reacts with |
ITGAV | NCI_NATURE; |
reacts with |
ITGB3 | NCI_NATURE; |
reacts with |
KDR | NCI_NATURE; |
reacts with |
KDR | REACTOME; |
reacts with |
MYOF | NCI_NATURE; |
reacts with |
NRP1 | NCI_NATURE; |
reacts with |
NRP2 | NCI_NATURE; |
reacts with |
PAK2 | NCI_NATURE; |
reacts with |
PRKACA | NCI_NATURE; |
reacts with |
RHOA | NCI_NATURE; |
reacts with |
ROCK1 | NCI_NATURE; |
reacts with |
SH2D2A | NCI_NATURE; |
reacts with |
SHB | NCI_NATURE; |
reacts with |
SRC | NCI_NATURE; |
reacts with |
VEGFA | NCI_NATURE; |
reacts with |
VEGFC | NCI_NATURE; |
reacts with |
VTN | NCI_NATURE; |
state change |
AKAP1 | NCI_NATURE; |
state change |
DNM2 | NCI_NATURE; |
state change |
FBXW11 | NCI_NATURE; |
state change |
ITGA1 | NCI_NATURE; |
state change |
ITGB1 | NCI_NATURE; |
state change |
KDR | NCI_NATURE; |
state change |
MYOF | NCI_NATURE; |
state change |
PTPN6 | NCI_NATURE; |
state change |
PTPRJ | NCI_NATURE; |
state change |
VTN | NCI_NATURE; |