Pediatric cancer gene database (Pedican) Home
Pedican
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7172

Name

TPMT

Synonym

-;thiopurine S-methyltransferase;TPMT;thiopurine S-methyltransferase

Definition

S-adenosyl-L-methionine:thiopurine S-methyltransferase

Position

6p22.3

Gene Type

protein-coding

Pathways and Diseases

Pathway

Methylation;PID Reactome;500215

Pathway

Drug metabolism - other enzymes;KEGG PATHWAY;hsa00983

Pathway

Biological oxidations;Reactome;REACT:13433

Disease

Hyperhomocysteinemia;FunDO

Disease

hepatotoxicity leukopenia;GAD

Disease

leukemia;GAD

Disease

IMMUNE;GAD

Disease

kidney transplant;GAD

Disease

CANCER;GAD

Disease

Multiple sclerosis;FunDO

Disease

Drug Hypersensitivity;GAD

Disease

Leukemia;FunDO

Disease

PHARMACOGENOMIC;GAD

Disease

METABOLIC;GAD

Disease

cirrhosis, biliary primary hepatitis, autoimmune;GAD

Disease

6-mercaptopurine sensitivity;OMIM

Disease

RENAL;GAD

External Links

Links to Entrez Gene

7172

Links to all GeneRIF Items

7172

Links to iHOP

7172

Sequence Information

Nucleotide Sequence

>7172 : length: 738
atggatggtacaagaacttcacttgacattgaagagtactcggatactgaggtacagaaa
aaccaagtactaactctggaagaatggcaagacaagtgggtgaacggcaagactgctttt
catcaggaacaaggacatcagctattaaagaagcatttagatactttccttaaaggcaag
agtggactgagggtattttttcctctttgcggaaaagcggttgagatgaaatggtttgca
gaccggggacacagtgtagttggtgtggaaatcagtgaacttgggatacaagaatttttt
acagagcagaatctttcttactcagaagaaccaatcaccgaaattcctggaaccaaagta
tttaagagttcttcggggaacatttcattgtactgttgcagtatttttgatcttcccagg
acaaatattggcaaatttgacatgatttgggatagaggagcattagttgccatcaatcca
ggtgatcgcaaatgctatgcagatacaatgttttccctcctgggaaagaagtttcagtat
ctcctgtgtgttctttcttatgatccaactaaacatccaggtccaccattttatgttcca
catgctgaaattgaaaggttgtttggtaaaatatgcaatatacgttgtcttgagaaggtt
gatgcttttgaagaacgacataaaagttggggaattgactgtctttttgaaaagttatat
ctacttacagaaaagtaa

Protein Sequence

>7172 : length: 245
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGK
SGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKV
FKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQY
LLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLY
LLTEK



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