| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3106 |
Name | HLA-B |
Synonym | AS|HLAB|SPDA1;major histocompatibility complex, class I, B;HLA-B;major histocompatibility complex, class I, B |
Definition | HLA class I histocompatibility antigen, B alpha chain|MHC Class I HLA heavy chain|MHC HLA-B cell surface glycoprotein|MHC HLA-B transmembrane glycoprotein|MHC class I antigen GN00104|MHC class I antigen HLA-B heavy chain|MHC class I antigen SHCHA|leukocyt |
Position | 6p21.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Antigen processing and presentation;KEGG PATHWAY;hsa04612 |
Pathway | Type I diabetes mellitus;KEGG PATHWAY;hsa04940 |
Pathway | Allograft rejection;KEGG PATHWAY;hsa05330 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | Graft-versus-host disease;KEGG PATHWAY;hsa05332 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | Autoimmune thyroid disease;KEGG PATHWAY;hsa05320 |
Disease | Lupus erythematosus;FunDO |
Disease | Abacavir hypersensitivity, susceptibility to;OMIM |
Disease | Graves disease;GAD |
Disease | complement C4 complotypes;GAD |
Disease | Rheumatic fever;FunDO |
Disease | endometriosis;GAD |
Disease | leukemia, chronic lymphocytic;GAD |
Disease | Spondyloarthropathy, susceptibility to, 1;OMIM |
Disease | Lung cancer;FunDO |
Disease | Periodontitis;FunDO |
Disease | thrombosis, deep vein;GAD |
Disease | spondyloarthropathies;GAD |
Disease | Psoriasis;FunDO |
Disease | Nasopharyngeal cancer;FunDO |
Disease | ankylosing spondylitis;GAD |
Disease | Liver cancer;FunDO |
Disease | Mucocutaneous lymph node syndrome;FunDO |
Disease | Henoch-Schoenlein purpura;FunDO |
Disease | Takayasu's arteritis;FunDO |
Disease | pulmonary hypertension;GAD |
Disease | Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to;OMIM |
Disease | hepatitis B;GAD |
Disease | Chronic Hepatitis C;GAD |
Disease | hepatitis C;GAD |
Disease | Dermatitis;FunDO |
Disease | leukemia;GAD |
Disease | Stevens-Johnson Syndrome;GAD |
Disease | IMMUNE;GAD |
Disease | Infection;FunDO |
Disease | HIV;GAD |
Disease | Alopecia;FunDO |
Disease | pulmonary thromboembolism;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | Leukemia;FunDO |
Disease | PHARMACOGENOMIC;GAD |
Disease | AIDS;GAD |
Disease | drug-induced liver injury (flucloxacillin);GAD |
Disease | Viremia;FunDO |
Disease | Schizophrenia;FunDO |
Disease | pemphigus;GAD |
Disease | INFECTION;GAD |
Disease | Cervical cancer;FunDO |
Disease | Larynx cancer;FunDO |
Disease | METABOLIC;GAD |
Disease | Autoimmune disease;FunDO |
Disease | cholangitis, sclerosing;GAD |
Disease | Spondylarthropathies;GAD |
Disease | primary sclerosing cholangitis;GAD |
Disease | periodontitis;GAD |
Disease | HIV Infections;GAD |
Disease | Celiac Disease;GAD |
Disease | REPRODUCTION;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Haemophilia with Chronic synovitis;GAD |
Disease | lung cancer;GAD |
Disease | CANCER;GAD |
Disease | Heart failure;FunDO |
Disease | Nasopharyngeal carcinoma;NHGRI |
Disease | acute anterior uveitis;GAD |
Disease | Endometriosis;FunDO |
Disease | hypertrophic cardiomyopathy;GAD |
Disease | height;GAD |
Disease | Breast cancer;FunDO |
Disease | Drug-induced liver injury due to flucloxacillin;OMIM |
Disease | Behcet's Disease;GAD |
Disease | Virus disease;FunDO |
Disease | Behcet syndrome;FunDO |
Disease | Lambert-Eaton myasthenic syndrome;GAD |
Disease | vitiligo;GAD |
Disease | multiple sclerosis;GAD |
Disease | HIV-1 control;GAD |
Disease | Multiple sclerosis;NHGRI |
Disease | ankylosing spondylitis independent of HLA-B27;GAD |
Disease | psoriatic arthritis;GAD |
Disease | Synovitis, chronic, susceptibility to;OMIM |
Disease | Spondylarthropathies;FunDO |
Disease | HIV-1 control;NHGRI |
Disease | Chinese ankylosing spondylitis patients;GAD |
Disease | CD4:CD8 lymphocyte ratio;NHGRI |
Disease | Height;NHGRI |
External Links | |
Links to Entrez Gene | 3106 |
Links to all GeneRIF Items | 3106 |
Links to iHOP | 3106 |
Sequence Information | |
Nucleotide Sequence | >3106 : length: 1089 atgctggtcatggcgccccgaaccgtcctcctgctgctctcggcggccctggccctgacc gagacctgggccggctcccactccatgaggtatttctacacctccgtgtcccggcccggc cgcggggagccccgcttcatctcagtgggctacgtggacgacacccagttcgtgaggttc gacagcgacgccgcgagtccgagagaggagccgcgggcgccgtggatagagcaggagggg ccggagtattgggaccggaacacacagatctacaaggcccaggcacagactgaccgagag agcctgcggaacctgcgcggctactacaaccagagcgaggccgggtctcacaccctccag agcatgtacggctgcgacgtggggccggacgggcgcctcctccgcgggcatgaccagtac gcctacgacggcaaggattacatcgccctgaacgaggacctgcgctcctggaccgccgcg gacacggcggctcagatcacccagcgcaagtgggaggcggcccgtgaggcggagcagcgg agagcctacctggagggcgagtgcgtggagtggctccgcagatacctggagaacgggaag gacaagctggagcgcgctgaccccccaaagacacacgtgacccaccaccccatctctgac catgaggccaccctgaggtgctgggccctgggtttctaccctgcggagatcacactgacc tggcagcgggatggcgaggaccaaactcaggacactgagcttgtggagaccagaccagca ggagatagaaccttccagaagtgggcagctgtggtggtgccttctggagaagagcagaga tacacatgccatgtacagcatgaggggctgccgaagcccctcaccctgagatgggagccg tcttcccagtccaccgtccccatcgtgggcattgttgctggcctggctgtcctagcagtt gtggtcatcggagctgtggtcgctgctgtgatgtgtaggaggaagagttcaggtggaaaa ggagggagctactctcaggctgcgtgcagcgacagtgcccagggctctgatgtgtctctc acagcttga |
Protein Sequence | >3106 : length: 362 MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRF DSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQ SMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQR RAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP SSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSL TA |