| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2157 |
Name | F8 |
Synonym | AHF|DXS1253E|F8B|F8C|FVIII|HEMA;coagulation factor VIII, procoagulant component;F8;coagulation factor VIII, procoagulant component |
Definition | antihemophilic factor|coagulation factor VIII|coagulation factor VIIIc|factor VIII F8B |
Position | Xq28 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | intrinsic prothrombin activation pathway;PID BioCarta;100122 |
Pathway | Intrinsic Pathway;PID Reactome;500302 |
Pathway | Hemostasis;Reactome;REACT:604 |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | HEMATOLOGICAL;GAD |
Disease | Myocardial Infarction;GAD |
Disease | thrombosis, deep vein;GAD |
Disease | Breast cancer;FunDO |
Disease | Hemophilia A;OMIM |
Disease | Brain Infarction;GAD |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | VISION;GAD |
Disease | coronary heart disease;GAD |
Disease | Leukemia;FunDO |
Disease | Stroke;FunDO |
Disease | thromboembolism, venous;GAD |
Disease | Cirrhosis;FunDO |
Disease | Vascular disease;FunDO |
Disease | Capillaries disease;FunDO |
Disease | Sarcoma;FunDO |
Disease | Venous Thrombosis;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | Hemophilia;KEGG DISEASE;H00219 |
Disease | Rabies;FunDO |
Disease | Hemorrhagic disorder;FunDO |
Disease | retinal artery occlusion;GAD |
Disease | hemophilia;GAD |
Disease | Malignant childhood tumor;FunDO |
Disease | Hemophilia;FunDO |
Disease | cerebrovascular disease;GAD |
Disease | Thrombophilia;FunDO |
Disease | factor VIII and factor IX genes;GAD |
Disease | Atherosclerosis;FunDO |
External Links | |
Links to Entrez Gene | 2157 |
Links to all GeneRIF Items | 2157 |
Links to iHOP | 2157 |
Sequence Information | |
Nucleotide Sequence | >2157 : length: 7056 atgcaaatagagctctccacctgcttctttctgtgccttttgcgattctgctttagtgcc accagaagatactacctgggtgcagtggaactgtcatgggactatatgcaaagtgatctc ggtgagctgcctgtggacgcaagatttcctcctagagtgccaaaatcttttccattcaac acctcagtcgtgtacaaaaagactctgtttgtagaattcacggatcaccttttcaacatc gctaagccaaggccaccctggatgggtctgctaggtcctaccatccaggctgaggtttat gatacagtggtcattacacttaagaacatggcttcccatcctgtcagtcttcatgctgtt ggtgtatcctactggaaagcttctgagggagctgaatatgatgatcagaccagtcaaagg gagaaagaagatgataaagtcttccctggtggaagccatacatatgtctggcaggtcctg aaagagaatggtccaatggcctctgacccactgtgccttacctactcatatctttctcat gtggacctggtaaaagacttgaattcaggcctcattggagccctactagtatgtagagaa gggagtctggccaaggaaaagacacagaccttgcacaaatttatactactttttgctgta tttgatgaagggaaaagttggcactcagaaacaaagaactccttgatgcaggatagggat gctgcatctgctcgggcctggcctaaaatgcacacagtcaatggttatgtaaacaggtct ctgccaggtctgattggatgccacaggaaatcagtctattggcatgtgattggaatgggc accactcctgaagtgcactcaatattcctcgaaggtcacacatttcttgtgaggaaccat cgccaggcgtccttggaaatctcgccaataactttccttactgctcaaacactcttgatg gaccttggacagtttctactgttttgtcatatctcttcccaccaacatgatggcatggaa gcttatgtcaaagtagacagctgtccagaggaaccccaactacgaatgaaaaataatgaa gaagcggaagactatgatgatgatcttactgattctgaaatggatgtggtcaggtttgat gatgacaactctccttcctttatccaaattcgctcagttgccaagaagcatcctaaaact tgggtacattacattgctgctgaagaggaggactgggactatgctcccttagtcctcgcc cccgatgacagaagttataaaagtcaatatttgaacaatggccctcagcggattggtagg aagtacaaaaaagtccgatttatggcatacacagatgaaacctttaagactcgtgaagct attcagcatgaatcaggaatcttgggacctttactttatggggaagttggagacacactg ttgattatatttaagaatcaagcaagcagaccatataacatctaccctcacggaatcact gatgtccgtcctttgtattcaaggagattaccaaaaggtgtaaaacatttgaaggatttt ccaattctgccaggagaaatattcaaatataaatggacagtgactgtagaagatgggcca actaaatcagatcctcggtgcctgacccgctattactctagtttcgttaatatggagaga gatctagcttcaggactcattggccctctcctcatctgctacaaagaatctgtagatcaa agaggaaaccagataatgtcagacaagaggaatgtcatcctgttttctgtatttgatgag aaccgaagctggtacctcacagagaatatacaacgctttctccccaatccagctggagtg cagcttgaggatccagagttccaagcctccaacatcatgcacagcatcaatggctatgtt tttgatagtttgcagttgtcagtttgtttgcatgaggtggcatactggtacattctaagc attggagcacagactgacttcctttctgtcttcttctctggatataccttcaaacacaaa atggtctatgaagacacactcaccctattcccattctcaggagaaactgtcttcatgtcg atggaaaacccaggtctatggattctggggtgccacaactcagactttcggaacagaggc atgaccgccttactgaaggtttctagttgtgacaagaacactggtgattattacgaggac agttatgaagatatttcagcatacttgctgagtaaaaacaatgccattgaaccaagaagc ttctcccagaattcaagacaccctagcactaggcaaaagcaatttaatgccaccacaatt ccagaaaatgacatagagaagactgacccttggtttgcacacagaacacctatgcctaaa atacaaaatgtctcctctagtgatttgttgatgctcttgcgacagagtcctactccacat gggctatccttatctgatctccaagaagccaaatatgagactttttctgatgatccatca cctggagcaatagacagtaataacagcctgtctgaaatgacacacttcaggccacagctc catcacagtggggacatggtatttacccctgagtcaggcctccaattaagattaaatgag aaactggggacaactgcagcaacagagttgaagaaacttgatttcaaagtttctagtaca tcaaataatctgatttcaacaattccatcagacaatttggcagcaggtactgataataca agttccttaggacccccaagtatgccagttcattatgatagtcaattagataccactcta tttggcaaaaagtcatctccccttactgagtctggtggacctctgagcttgagtgaagaa aataatgattcaaagttgttagaatcaggtttaatgaatagccaagaaagttcatgggga aaaaatgtatcgtcaacagagagtggtaggttatttaaagggaaaagagctcatggacct gctttgttgactaaagataatgccttattcaaagttagcatctctttgttaaagacaaac aaaacttccaataattcagcaactaatagaaagactcacattgatggcccatcattatta attgagaatagtccatcagtctggcaaaatatattagaaagtgacactgagtttaaaaaa gtgacacctttgattcatgacagaatgcttatggacaaaaatgctacagctttgaggcta aatcatatgtcaaataaaactacttcatcaaaaaacatggaaatggtccaacagaaaaaa gagggccccattccaccagatgcacaaaatccagatatgtcgttctttaagatgctattc ttgccagaatcagcaaggtggatacaaaggactcatggaaagaactctctgaactctggg caaggccccagtccaaagcaattagtatccttaggaccagaaaaatctgtggaaggtcag aatttcttgtctgagaaaaacaaagtggtagtaggaaagggtgaatttacaaaggacgta ggactcaaagagatggtttttccaagcagcagaaacctatttcttactaacttggataat ttacatgaaaataatacacacaatcaagaaaaaaaaattcaggaagaaatagaaaagaag gaaacattaatccaagagaatgtagttttgcctcagatacatacagtgactggcactaag aatttcatgaagaaccttttcttactgagcactaggcaaaatgtagaaggttcatatgac ggggcatatgctccagtacttcaagattttaggtcattaaatgattcaacaaatagaaca aagaaacacacagctcatttctcaaaaaaaggggaggaagaaaacttggaaggcttggga aatcaaaccaagcaaattgtagagaaatatgcatgcaccacaaggatatctcctaataca agccagcagaattttgtcacgcaacgtagtaagagagctttgaaacaattcagactccca ctagaagaaacagaacttgaaaaaaggataattgtggatgacacctcaacccagtggtcc aaaaacatgaaacatttgaccccgagcaccctcacacagatagactacaatgagaaggag aaaggggccattactcagtctcccttatcagattgccttacgaggagtcatagcatccct caagcaaatagatctccattacccattgcaaaggtatcatcatttccatctattagacct atatatctgaccagggtcctattccaagacaactcttctcatcttccagcagcatcttat agaaagaaagattctggggtccaagaaagcagtcatttcttacaaggagccaaaaaaaat aacctttctttagccattctaaccttggagatgactggtgatcaaagagaggttggctcc ctggggacaagtgccacaaattcagtcacatacaagaaagttgagaacactgttctcccg aaaccagacttgcccaaaacatctggcaaagttgaattgcttccaaaagttcacatttat cagaaggacctattccctacggaaactagcaatgggtctcctggccatctggatctcgtg gaagggagccttcttcagggaacagagggagcgattaagtggaatgaagcaaacagacct ggaaaagttccctttctgagagtagcaacagaaagctctgcaaagactccctccaagcta ttggatcctcttgcttgggataaccactatggtactcagataccaaaagaagagtggaaa tcccaagagaagtcaccagaaaaaacagcttttaagaaaaaggataccattttgtccctg aacgcttgtgaaagcaatcatgcaatagcagcaataaatgagggacaaaataagcccgaa atagaagtcacctgggcaaagcaaggtaggactgaaaggctgtgctctcaaaacccacca gtcttgaaacgccatcaacgggaaataactcgtactactcttcagtcagatcaagaggaa attgactatgatgataccatatcagttgaaatgaagaaggaagattttgacatttatgat gaggatgaaaatcagagcccccgcagctttcaaaagaaaacacgacactattttattgct gcagtggagaggctctgggattatgggatgagtagctccccacatgttctaagaaacagg gctcagagtggcagtgtccctcagttcaagaaagttgttttccaggaatttactgatggc tcctttactcagcccttataccgtggagaactaaatgaacatttgggactcctggggcca tatataagagcagaagttgaagataatatcatggtaactttcagaaatcaggcctctcgt ccctattccttctattctagccttatttcttatgaggaagatcagaggcaaggagcagaa cctagaaaaaactttgtcaagcctaatgaaaccaaaacttacttttggaaagtgcaacat catatggcacccactaaagatgagtttgactgcaaagcctgggcttatttctctgatgtt gacctggaaaaagatgtgcactcaggcctgattggaccccttctggtctgccacactaac acactgaaccctgctcatgggagacaagtgacagtacaggaatttgctctgtttttcacc atctttgatgagaccaaaagctggtacttcactgaaaatatggaaagaaactgcagggct ccctgcaatatccagatggaagatcccacttttaaagagaattatcgcttccatgcaatc aatggctacataatggatacactacctggcttagtaatggctcaggatcaaaggattcga tggtatctgctcagcatgggcagcaatgaaaacatccattctattcatttcagtggacat gtgttcactgtacgaaaaaaagaggagtataaaatggcactgtacaatctctatccaggt gtttttgagacagtggaaatgttaccatccaaagctggaatttggcgggtggaatgcctt attggcgagcatctacatgctgggatgagcacactttttctggtgtacagcaataagtgt cagactcccctgggaatggcttctggacacattagagattttcagattacagcttcagga caatatggacagtgggccccaaagctggccagacttcattattccggatcaatcaatgcc tggagcaccaaggagcccttttcttggatcaaggtggatctgttggcaccaatgattatt cacggcatcaagacccagggtgcccgtcagaagttctccagcctctacatctctcagttt atcatcatgtatagtcttgatgggaagaagtggcagacttatcgaggaaattccactgga accttaatggtcttctttggcaatgtggattcatctgggataaaacacaatatttttaac cctccaattattgctcgatacatccgtttgcacccaactcattatagcattcgcagcact cttcgcatggagttgatgggctgtgatttaaatagttgcagcatgccattgggaatggag agtaaagcaatatcagatgcacagattactgcttcatcctactttaccaatatgtttgcc acctggtctccttcaaaagctcgacttcacctccaagggaggagtaatgcctggagacct caggtgaataatccaaaagagtggctgcaagtggacttccagaagacaatgaaagtcaca ggagtaactactcagggagtaaaatctctgcttaccagcatgtatgtgaaggagttcctc atctccagcagtcaagatggccatcagtggactctcttttttcagaatggcaaagtaaag gtttttcagggaaatcaagactccttcacacctgtggtgaactctctagacccaccgtta ctgactcgctaccttcgaattcacccccagagttgggtgcaccagattgccctgaggatg gaggttctgggctgcgaggcacaggacctctactga |
Protein Sequence | >2157 : length: 2351 MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFN TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLA PDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTL LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRG MTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTI PENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPS PGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSST SNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEE NNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTN KTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRL NHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSG QGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDN LHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYD GAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKE KGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASY RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLP KPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRP GKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSL NACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEE IDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNR AQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASR PYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDV DLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRA PCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGH VFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKC QTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMII HGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFN PPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFA TWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFL ISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRM EVLGCEAQDLY |