| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 1728 |
Name | NQO1 |
Synonym | DHQU|DIA4|DTD|NMOR1|NMORI|QR1;NAD(P)H dehydrogenase, quinone 1;NQO1;NAD(P)H dehydrogenase, quinone 1 |
Definition | DT-diaphorase|NAD(P)H dehydrogenase [quinone] 1|NAD(P)H:Quinone acceptor oxidoreductase type 1|NAD(P)H:menadione oxidoreductase 1|NAD(P)H:quinone oxidoreductase 1|NAD(P)H:quinone oxireductase|azoreductase|diaphorase (NADH/NADPH) (cytochrome b-5 reductase) |
Position | 16q22.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Metabolism of amino acids and derivatives;Reactome;REACT:13 |
Pathway | Regulation of ornithine decarboxylase (ODC);PID Reactome;500789 |
Disease | Leukemia, post-chemotherapy, susceptibility to;OMIM |
Disease | leukemia, myeloid;GAD |
Disease | urothelial cancer;GAD |
Disease | esophageal squamous cell carcinoma;GAD |
Disease | Barrett esophagus esophageal cancer;GAD |
Disease | bladder cancer;GAD |
Disease | leukemia, myelodysplastic (TRLIMDS);GAD |
Disease | Benzene toxicity, susceptibility to;OMIM |
Disease | nasopharyngeal cancer;GAD |
Disease | lung cancer;GAD |
Disease | cognitive function;GAD |
Disease | Parkinson's disease;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Breast cancer, poor survival after chemotherapy for;OMIM |
Disease | METABOLIC;GAD |
Disease | benzene toxicity;GAD |
Disease | Alzheimer's disease;GAD |
Disease | colorectal cancer;GAD |
Disease | diabetes, type 2;GAD |
Disease | esophageal cancer;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | esophageal cancer and gastric cardiac carcinoma;GAD |
Disease | CANCER;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | leukemia;GAD |
Disease | decreased lung cancer risk;GAD |
Disease | urolithiasis;GAD |
Disease | breast cancer;GAD |
Disease | cytogenetic studies;GAD |
Disease | adenocarcinoma of the upper gastrointestinal tract.;GAD |
External Links | |
Links to Entrez Gene | 1728 |
Links to all GeneRIF Items | 1728 |
Links to iHOP | 1728 |
Sequence Information | |
Nucleotide Sequence | >1728 : length: 825 atggtcggcagaagagcactgatcgtactggctcactcagagaggacgtccttcaactat gccatgaaggaggctgctgcagcggctttgaagaagaaaggatgggaggtggtggagtcg gacctctatgccatgaacttcaatcccatcatttccagaaaggacatcacaggtaaactg aaggaccctgcgaactttcagtatcctgccgagtctgttctggcttataaagaaggccat ctgagcccagatattgtggctgaacaaaagaagctggaagccgcagaccttgtgatattc cagttccccctgcagtggtttggagtccctgccattctgaaaggctggtttgagcgagtg ttcataggagagtttgcttacacttacgctgccatgtatgacaaaggacccttccggagt aagaaggcagtgctttccatcaccactggtggcagtggctccatgtactctctgcaaggg atccacggggacatgaatgtcattctctggccaattcagagtggcattctgcatttctgt ggcttccaagtcttagaacctcaactgacatatagcattgggcacactccagcagacgcc cgaattcaaatcctggaaggatggaagaaacgcctggagaatatttgggatgagacacca ctgtattttgctccaagcagcctctttgacctaaacttccaggcaggattcttaatgaaa aaagaggtacaggatgaggagaaaaacaagaaatttggcctttctgtgggccatcacttg ggcaagtccatcccaactgacaaccagatcaaagctagaaaatga |
Protein Sequence | >1728 : length: 274 MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK |