| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 11200 |
Name | CHEK2 |
Synonym | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1;checkpoint kinase 2;CHEK2;checkpoint kinase 2 |
Definition | CHK2 checkpoint homolog|cds1 homolog|checkpoint-like protein CHK2|protein kinase CHK2|serine/threonine-protein kinase Chk2 |
Position | 22q11|22q12.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | PLK3 signaling events;PID Curated;200186 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | G2/M DNA damage checkpoint;PID Reactome;500952 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | p53 pathway;PID Curated;200175 |
Disease | Breast and colorectal cancer, susceptibility to;OMIM |
Disease | Vertical cup-disc ratio;NHGRI |
Disease | overall effect;GAD |
Disease | cancer;GAD |
Disease | Cancer;FunDO |
Disease | Prostate cancer, familial, susceptibility to;OMIM |
Disease | Leukoencephalopathy;FunDO |
Disease | prostate cancer;GAD |
Disease | METABOLIC;GAD |
Disease | estrogen receptor status;GAD |
Disease | upper aerodigestive tract cancer;GAD |
Disease | colorectal cancer;GAD |
Disease | diabetes, type 2;GAD |
Disease | endometrial cancer;GAD |
Disease | CANCER;GAD |
Disease | Yersinia infection;FunDO |
Disease | Li-Fraumeni syndrome;OMIM |
Disease | breast cancer;GAD |
Disease | Breast cancer, susceptibility to;OMIM |
Disease | Osteosarcoma, somatic;OMIM |
Disease | ovarian cancer;GAD |
Disease | Esophageal cancer and gastric cancer;NHGRI |
External Links | |
Links to Entrez Gene | 11200 |
Links to all GeneRIF Items | 11200 |
Links to iHOP | 11200 |
Sequence Information | |
Nucleotide Sequence | >11200 : length: 1761 atgtctcgggagtcggatgttgaggctcagcagtctcatggcagcagtgcctgttcacag ccccatggcagcgttacccagtcccaaggctcctcctcacagtcccagggcatatccagc tcctctaccagcacgatgccaaactccagccagtcctctcactccagctctgggacactg agctccttagagacagtgtccactcaggaactctattctattcctgaggaccaagaacct gaggaccaagaacctgaggagcctacccctgccccctgggctcgattatgggcccttcag gatggatttgccaatcttgagacagagtctggccatgttacccaatctgatcttgaactc ctgctgtcatctgatcctcctgcctcagcctcccaaagtgctgggataagaggtgtgagg caccatccccggccagtttgcagtctaaaatgtgtgaatgacaactactggtttgggagg gacaaaagctgtgaatattgctttgatgaaccactgctgaaaagaacagataaataccga acatacagcaagaaacactttcggattttcagggaagtgggtcctaaaaactcttacatt gcatacatagaagatcacagtggcaatggaacctttgtaaatacagagcttgtagggaaa ggaaaacgccgtcctttgaataacaattctgaaattgcactgtcactaagcagaaataaa gtttttgtcttttttgatctgactgtagatgatcagtcagtttatcctaaggcattaaga gatgaatacatcatgtcaaaaactcttggaagtggtgcctgtggagaggtaaagctggct ttcgagaggaaaacatgtaagaaagtagccataaagatcatcagcaaaaggaagtttgct attggttcagcaagagaggcagacccagctctcaatgttgaaacagaaatagaaattttg aaaaagctaaatcatccttgcatcatcaagattaaaaacttttttgatgcagaagattat tatattgttttggaattgatggaagggggagagctgtttgacaaagtggtggggaataaa cgcctgaaagaagctacctgcaagctctatttttaccagatgctcttggctgtgcagtac cttcatgaaaacggtattatacaccgtgacttaaagccagagaatgttttactgtcatct caagaagaggactgtcttataaagattactgattttgggcactccaagattttgggagag acctctctcatgagaaccttatgtggaacccccacctacttggcgcctgaagttcttgtt tctgttgggactgctgggtataaccgtgctgtggactgctggagtttaggagttattctt tttatctgccttagtgggtatccacctttctctgagcataggactcaagtgtcactgaag gatcagatcaccagtggaaaatacaacttcattcctgaagtctgggcagaagtctcagag aaagctctggaccttgtcaagaagttgttggtagtggatccaaaggcacgttttacgaca gaagaagccttaagacacccgtggcttcaggatgaagacatgaagagaaagtttcaagat cttctgtctgaggaaaatgaatccacagctctaccccaggttctagcccagccttctact agtcgaaagcggccccgtgaaggggaagccgagggtgccgagaccacaaagcgcccagct gtgtgtgctgctgtgttgtga |
Protein Sequence | >11200 : length: 586 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGHVTQSDLEL LLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYCFDEPLLKRTDKYR TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL |