Entrez Gene

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General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information
Gene ID	7486
Name	WRN
Synonymous	Werner syndrome, RecQ helicase-like;WRN;Werner syndrome, RecQ helicase-like
Definition	DNA helicase, RecQ-like type 3\|Werner syndrome ATP-dependent helicase\|exonuclease WRN\|recQ protein-like 2
Position	8p12
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
PCNA(h) + WS(h) <==> PCNA(h):WS(h) (binding)
WS(h) + TopoI(h) <==> WS(h):TopoI(h) (binding)
WS(h) + FEN1(h) <==> WS(h):FEN1(h) (binding)
WS(h) + NBS1(h) + Mre11(h) + Rad50(h) <==> WS(h):Mre11(h):NBS1(h):Rad50(h) (binding)
WRN(h) --> WS(h) (expression).
FEN1(h) + WS(h) <==> FEN1(h):WS(h) (binding)
WS(h) + FEN1(h){ace} <==> WS(h):FEN1(h){ace} (binding)
WS(h) + NBS1(h) <==> WS(h):NBS1(h) (binding)
WS(h) + MRE11A(m.s.):NBS1(m.s.):RAD50(m.s.) <==> WS(h):MRE11A(m.s.):NBS1(m.s.):RAD50(m.s.) (binding)
WS(h) + 2 ATP --ATM(m.s.)--> WS(h){pS1141}{pS1292} + 2 ADP (phosphorylation)
WS(h) + 2 ATP --ATR(m.s.)--> WS(h){pS1141}{pS1292} + 2 ADP (phosphorylation)
WS(h) + 2 ATP --DNA-PK(m.s.)--> WS(h){pS1141}{pS1292} + 2 ADP (phosphorylation)
WRN(h) --> WS(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
1141	Phosphoserine (ATM)	11252893;10839545	Phospho.ELM 6.0
1292	Phosphoserine (ATM)	10608806	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr8	Promoter: 31008820 - 31010820	GoldenGate_Methylation_Cancer_Panel_I
chr8	Promoter: 31008820 - 31010820	GSE27584
chr8	Promoter: 31008820 - 31010820	Agilent_014791_44K
chr8	Promoter: 31008820 - 31010820	Agilent_014791
chr8	Promoter: 31008820 - 31010820	PMID:17372756
chr8	Promoter: 31008820 - 31010820	PMID:16723399

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