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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

7486

Name

WRN

Synonym

RECQ3|RECQL2|RECQL3;Werner syndrome, RecQ helicase-like;WRN;Werner syndrome, RecQ helicase-like

Definition

DNA helicase, RecQ-like type 3|Werner syndrome ATP-dependent helicase|exonuclease WRN|recQ protein-like 2

Position

8p12

Gene Type

protein-coding

Pathways and Diseases

Pathway

p53 pathway;PANTHER;P00059

Pathway

Regulation of Telomerase;PID Curated;200072

Disease

spondylosis, lumbar;GAD

Disease

Werner syndrome;FunDO

Disease

Diabetes mellitus;FunDO

Disease

exercise treadmill test traits;GAD

Disease

Exercise treadmill test traits;NHGRI

Disease

Systemic scleroderma;FunDO

Disease

Defects in RecQ helicases;KEGG DISEASE;H00296

Disease

METABOLIC;GAD

Disease

bone density;GAD

Disease

diabetes, type 2;GAD

Disease

Sarcoma;FunDO

Disease

Genetic disorders;KEGG DISEASE

Disease

Inherited disorders of DNA repair systems;KEGG DISEASE

Disease

Coronary Artery Disease;GAD

Disease

CARDIOVASCULAR;GAD

Disease

Stroke;GAD

Disease

CANCER;GAD

Disease

Myocardial Infarction;GAD

Disease

Werner syndrome;OMIM

Disease

bone density but not spondylosis;GAD

Disease

Hypertension/complications*;GAD

Disease

breast cancer;GAD

Disease

Waldenstrom macroglobulinaemia;GAD

Disease

Atherosclerosis;FunDO

External Links

Links to Entrez Gene

7486

Links to all GeneRIF Items

7486

Links to iHOP

7486

Sequence Information

Nucleotide Sequence

>7486 : length: 5765
CAGCCGCCCCTCCTGCGGCCGCTGCGGGGGCCGCCGCCTGACTTCGGACACCGGCCCCGC
ACCCGCCAGGAGGGGAGGGAAGGGGAGGCGGGGAGAGCGACGGCGGGGGGCGGGCGGTGG
ACCCCGCCTCCCCCGGCACAGCCTGCTGAGGGGAAGAGGGGGTCTCCGCTCTTCCTCAGT
GCACTCTCTGACTGAAGCCCGGCGCGTGGGGTGCAGCGGGAGTGCGAGGGGACTGGACAG
GTGGGAAGATGGGAATGAGGACCGGGCGGCGGGAATGTTCTCACTTCTCCGGATTCCACC
GGGATGCAGGACTCTAGCTGCCCAGCCGCACCTGCGAAGAGACTACACTTCCCGAGGTGC
TCAGCGGCAGCGAGGGCCTCCACGCATGCGCACCGCGGCGCGCTGGGCGGGGCTGGATGG
GCTGTGGTGGGAGGGTTGCAGCGCCGCGAGAAAGGCGAGCCGGGCCGGGGGCGGGGAAAG
GGGTGGGGCAGGAACGGGGGCGGGGACGGCGCTGGAGGGGCGGGTCGGGTAGGTCTCCCG
GAGCTGATGTGTACTGTGTGCGCCGGGGAGGCGCCGGCTTGTACTCGGCAGCGCGGGAAT
AAAGTTTGCTGATTTGGTGTCTAGCCTGGATGCCTGGGTTGCAGGCCCTGCTTGTGGTGG
CGCTCCACAGTCATCCGGCTGAAGAAGACCTGTTGGACTGGATCTTCTCGGGTTTTCTTT
CAGATATTGTTTTGTATTTACCCATGAAGACATTGTTTTTTGGACTCTGCAAATAGGACA
TTTCAAAGATGAGTGAAAAAAAATTGGAAACAACTGCACAGCAGCGGAAATGTCCTGAAT
GGATGAATGTGCAGAATAAAAGATGTGCTGTAGAAGAAAGAAAGGCATGTGTTCGGAAGA
GTGTTTTTGAAGATGACCTCCCCTTCTTAGAATTCACTGGATCCATTGTGTATAGTTACG
ATGCTAGTGATTGCTCTTTCCTGTCAGAAGATATTAGCATGAGTCTATCAGATGGGGATG
TGGTGGGATTTGACATGGAGTGGCCACCATTATACAATAGAGGGAAACTTGGCAAAGTTG
CACTAATTCAGTTGTGTGTTTCTGAGAGCAAATGTTACTTGTTCCACGTTTCTTCCATGT
CAGTTTTTCCCCAGGGATTAAAAATGTTGCTTGAAAATAAAGCAGTTAAAAAGGCAGGTG
TAGGAATTGAAGGAGATCAGTGGAAACTTCTACGTGACTTTGATATCAAATTGAAGAATT
TTGTGGAGTTGACAGATGTTGCCAATAAAAAGCTGAAATGCACAGAGACCTGGAGCCTTA
ACAGTCTGGTTAAACACCTCTTAGGTAAACAGCTCCTGAAAGACAAGTCTATCCGCTGTA
GCAATTGGAGTAAATTTCCTCTCACTGAGGACCAGAAACTGTATGCAGCCACTGATGCTT
ATGCTGGTTTTATTATTTACCGAAATTTAGAGATTTTGGATGATACTGTGCAAAGGTTTG
CTATAAATAAAGAGGAAGAAATCCTACTTAGCGACATGAACAAACAGTTGACTTCAATCT
CTGAGGAAGTGATGGATCTGGCTAAGCATCTTCCTCATGCTTTCAGTAAATTGGAAAACC
CACGGAGGGTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGA
TGATAATTGGGTCTACTAACATTGAGACTGAACTGAGGCCCAGCAATAATTTAAACTTAT
TATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAAG
TTTTAATTCACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATG
ATGGAGAAGATGTACTTGGAAATAAAGTGGAACGAAAAGAAGATGGATTTGAAGATGGAG
TAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATTA
CAGAACATGAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTG
CTTATAAATCTACTGAGCATTTATCTCCCAATGATAATGAAAACGATACGTCCTATGTAA
TTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAATG
AAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGT
CTTTAGAAAACCTCAATAGTGGCACGGTAGAACCAACTCATTCTAAATGCTTAAAAATGG
AAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAATG
AAGGGGAAGAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTA
CTTGCCTCAAGATGTACTTTGGCCATTCCAGTTTTAAACCAGTTCAGTGGAAAGTGATTC
ATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAGA
GTTTGTGCTTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCC
TTATTTCTCTGATGGAAGACCAAGTGCTACAGCTTAAAATGTCCAACATCCCAGCTTGCT
TCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGGA
TTGTATACGTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGG
CTGATATTGGTATCACGCTCATTGCTGTGGATGAGGCTCACTGTATTTCTGAGTGGGGGC
ATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTTC
CAATCGTTGCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCT
TAAATCTGAGAAATCCTCAGATCACCTGTACTGGTTTTGATCGACCAAACCTGTATTTAG
AAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACAA
GTTCCCACTGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACAC
AACAAGTTACAGGTGAACTTAGGAAACTGAATCTATCCTGTGGAACATACCATGCGGGCA
TGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGTG
TCATAGCTACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTC
ATTACGGTGCTCCTAAGGACATGGAATCATATTATCAGGAGATTGGTAGAGCTGGTCGTG
ATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGGC
ACCTTCTTACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAA
AGATGGAAAAATATCTTCATTCTAGCAGATGTAGGAGACAAATCATCTTGTCTCATTTTG
AGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGATA
ATTGCAGGTCCAGATTGGATCATTGCTATTCCATGGATGACTCAGAGGATACATCCTGGG
ACTTTGGTCCACAAGCATTTAAGCTTTTGTCTGCTGTGGACATCTTAGGCGAAAAATTTG
GAATTGGGCTTCCAATTTTATTTCTCCGAGGATCTAATTCTCAGCGTCTTGCCGATCAAT
ATCGCAGGCACAGTTTATTTGGCACTGGCAAGGATCAAACAGAGAGTTGGTGGAAGGCTT
TTTCCCGTCAGCTGATCACTGAGGGATTCTTGGTAGAAGTTTCTCGGTATAACAAATTTA
TGAAGATTTGCGCCCTTACGAAAAAGGGTAGAAATTGGCTTCATAAAGCTAATACAGAAT
CTCAGAGCCTCATCCTTCAAGCTAATGAAGAATTGTGTCCAAAGAAGTTGCTTCTGCCTA
GTTCGAAAACTGTATCTTCGGGCACCAAAGAGCATTGTTATAATCAAGTACCAGTTGAAT
TAAGTACAGAGAAGAAGTCTAACTTGGAGAAGTTATATTCTTATAAACCATGTGATAAGA
TTTCTTCTGGGAGTAACATTTCTAAAAAAAGTATCATGGTACAGTCACCAGAAAAAGCTT
ACAGTTCCTCACAGCCTGTTATTTCGGCACAAGAGCAGGAGACTCAGATTGTGTTATATG
GCAAATTGGTAGAAGCTAGGCAGAAACATGCCAATAAAATGGATGTTCCCCCAGCTATTC
TGGCAACAAACAAGATACTGGTGGATATGGCCAAAATGAGACCAACTACGGTTGAAAACG
TAAAAAGGATTGATGGTGTTTCTGAAGGCAAAGCTGCCATGTTGGCCCCTCTGTTGGAAG
TCATCAAACATTTCTGCCAAACAAATAGTGTTCAGACAGACCTCTTTTCAAGTACAAAAC
CTCAAGAAGAACAGAAGACGAGTCTGGTAGCAAAAAATAAAATATGCACACTTTCACAGT
CTATGGCCATCACATACTCTTTATTCCAAGAAAAGAAGATGCCTTTGAAGAGCATAGCTG
AGAGCAGGATTCTGCCTCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGCTG
GCTGCCCCCTTGATTTGGAGCGAGCAGGCCTGACTCCAGAGGTTCAGAAGATTATTGCTG
ATGTTATCCGAAACCCTCCCGTCAACTCAGATATGAGTAAAATTAGCCTAATCAGAATGT
TAGTTCCTGAAAACATTGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACATG
GTCCTGACAGCGGACTTCAACCTTCATGTGATGTCAACAAAAGGAGATGTTTTCCCGGTT
CTGAAGAGATCTGTTCAAGTTCTAAGAGAAGCAAGGAAGAAGTAGGCATCAATACTGAGA
CTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCA
GCAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACC
AGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATTTTATTTCTGAAGAGT
AAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGA
ACTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTA
CGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAAGATTGCTTTAAGAAA
CTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGT
GCTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATA
TTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATAGTTATTTTACAAATT
GTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAG
GGCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAA
TGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTATTTTATATACAATTTC
TATTATTTTTCAAGTAATAAAACAATGTTTTTCATACTGAATATTAAAAAAAAAAAAAAA
AAAAA

Protein Sequence

>7486 : length: 1432
MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF
PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE
ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS



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