| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6195 |
Name | RPS6KA1 |
Synonymous | ribosomal protein S6 kinase, 90kDa, polypeptide 1;RPS6KA1;ribosomal protein S6 kinase, 90kDa, polypeptide 1 |
Definition | 90 kDa ribosomal protein S6 kinase 1|MAP kinase-activated protein kinase 1a|MAPK-activated protein kinase 1a|MAPKAP kinase 1a|MAPKAPK-1a|RSK-1|S6K-alpha 1|S6K-alpha-1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|p90RSK1|p90S6K|r |
Position | 1p |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ERK1(h) + RSK1(h) <==> ERK1(h):RSK1(h) (binding) | ERK2(h) + RSK1(h) <==> ERK2(h):RSK1(h) (binding) | RSK1(h) + CBP(h) <==> RSK1(h):CBP(h) (binding) | RSK1(h) --/ FGF2(h) (transrepression) | RSK1(h) + CBP(v.s.) <==> RSK1(h):CBP(v.s.) (binding) | RSK1(h) + ERK5(h) <==> RSK1(h):ERK5(h) (binding) | ERK5(h) + RSK1(h) <==> ERK5(h):RSK1(h) (binding) | RSK1(h) + ATP --> RSK1(h){p} + ADP (phosphorylation) | RSK1(h) + ATP --> RSK1(h){pS380} + ADP (phosphorylation) | RSK1(h) + PKA-RI-alpha(b) <==> RSK1(h):PKA-RI-alpha(b) (binding) | RPS6KA1(h) --> RSK1(h) (expression). | MITF(h) + ATP --RSK1(h)--> MITF(h){pS409} + ADP (phosphorylation) | LKB1(m) + ATP --RSK1(h)--> LKB1(m){pS431} + ADP (phosphorylation) | bad(m) + ATP --RSK1(h)--> bad(m){p} + ADP (phosphorylation) | eIF-4B(m.s.) + ATP --RSK1(h)--> eIF-4B(m.s.){p} + ADP (phosphorylation) | RPS6KA1(h) --> RSK1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 221 | Phosphoserine. | Swiss-Prot 53.0 | 225 | Phosphothreonine. | Swiss-Prot 53.0 | 348 | Phosphothreonine. | Swiss-Prot 53.0 | 359 | Phosphothreonine. | Swiss-Prot 53.0 | 363 | Phosphoserine. | Swiss-Prot 53.0 | 369 | Phosphoserine. | Swiss-Prot 53.0 | 380 | Phosphoserine (by autocatalysis). | Swiss-Prot 53.0 | 573 | Phosphothreonine. | Swiss-Prot 53.0 | 732 | Phosphoserine. | Swiss-Prot 53.0 | 732 | Phosphoserine | 16083285 | Phospho.ELM 6.0 | 573 | Phosphothreonine | 7642538 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 26727336 - 26729336 | GSE27584 |
chr1 |
Promoter: 26727336 - 26729336 | Agilent_014791_44K |
chr1 |
Promoter: 26727336 - 26729336 | Agilent_014791 |