Entrez Gene

Basic Information
Gene ID	6195
Name	RPS6KA1
Synonymous	ribosomal protein S6 kinase, 90kDa, polypeptide 1;RPS6KA1;ribosomal protein S6 kinase, 90kDa, polypeptide 1
Definition	90 kDa ribosomal protein S6 kinase 1\|MAP kinase-activated protein kinase 1a\|MAPK-activated protein kinase 1a\|MAPKAP kinase 1a\|MAPKAPK-1a\|RSK-1\|S6K-alpha 1\|S6K-alpha-1\|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)\|p90-RSK 1\|p90RSK1\|p90S6K\|r
Position	1p
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1236G>T; p.L412L; 1:26560746-26560746	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1615A>T; p.S539C; 1:26571473-26571473	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1301G>A; p.R434H; 1:26560811-26560811	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.669C>T; p.C223C; 1:26554651-26554651	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2131A>C; p.T711P; 1:26574124-26574124	breast	carcinoma	Substitution - Missense
c.346C>T; p.L116L; 1:26551435-26551435	skin	malignant_melanoma	Substitution - coding silent
c.516T>C; p.A172A; 1:26553438-26553438	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.350C>A; p.A117D; 1:26551439-26551439	thyroid	other; neoplasm	Substitution - Missense
c.881G>A; p.R294Q; 1:26555590-26555590	breast	carcinoma	Substitution - Missense
c.1181G>T; p.R394L; 1:26558903-26558903	urinary_tract; bladder	carcinoma	Substitution - Missense
c.336G>A; p.E112E; 1:26551425-26551425	oesophagus	carcinoma	Substitution - coding silent
c.1098delC; p.S369fs*18; 1:26558820-26558820	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1098delC; p.S369fs*18; 1:26558820-26558820	NS	malignant_melanoma	Deletion - Frameshift
c.1098delC; p.S369fs*18; 1:26558820-26558820	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1423C>T; p.L475L; 1:26561126-26561126	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1849G>A; p.G617S; 1:26572195-26572195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.175C>T; p.P59S; 1:26546933-26546933	skin	malignant_melanoma	Substitution - Missense
c.1592T>C; p.V531A; 1:26571450-26571450	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2134C>T; p.P712S; 1:26574127-26574127	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.369C>T; p.F123F; 1:26551458-26551458	skin	malignant_melanoma	Substitution - coding silent
c.1785C>T; p.C595C; 1:26571881-26571881	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1002C>G; p.I334M; 1:26557018-26557018	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.101C>T; p.P34L; 1:26536962-26536962	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.323G>A; p.R108Q; 1:26551412-26551412	skin	malignant_melanoma	Substitution - Missense
c.1177C>A; p.P393T; 1:26558899-26558899	thyroid	other; neoplasm	Substitution - Missense
c.2102C>T; p.T701M; 1:26574095-26574095	skin	malignant_melanoma	Substitution - Missense
c.1170C>T; p.D390D; 1:26558892-26558892	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1437T>C; p.Y479Y; 1:26561510-26561510	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.51T>G; p.P17P; 1:26529971-26529971	thyroid	other; neoplasm	Substitution - coding silent
c.2159C>G; p.S720C; 1:26574152-26574152	skin	malignant_melanoma	Substitution - Missense
c.443A>T; p.D148V; 1:26551698-26551698	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1508G>A; p.R503Q; 1:26561581-26561581	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.147C>T; p.H49H; 1:26546905-26546905	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.118G>A; p.V40I; 1:26546876-26546876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1848C>T; p.N616N; 1:26572194-26572194	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.706C>T; p.R236C; 1:26554688-26554688	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.706C>T; p.R236C; 1:26554688-26554688	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2155T>C; p.S719P; 1:26574148-26574148	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.831G>A; p.A277A; 1:26555540-26555540	breast	carcinoma	Substitution - coding silent
c.1591G>T; p.V531F; 1:26571449-26571449	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.995G>A; p.R332H; 1:26557011-26557011	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.134C>T; p.S45F; 1:26546892-26546892	skin	malignant_melanoma	Substitution - Missense
c.506C>T; p.A169V; 1:26553428-26553428	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1601G>T; p.R534M; 1:26571459-26571459	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1641C>T; p.S547S; 1:26571499-26571499	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.993T>C; p.R331R; 1:26557009-26557009	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1205C>T; p.S402L; 1:26558927-26558927	skin	malignant_melanoma	Substitution - Missense
c.994C>T; p.R332C; 1:26557010-26557010	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1485G>A; p.G495G; 1:26561558-26561558	skin	malignant_melanoma	Substitution - coding silent
c.1559G>A; p.G520D; 1:26561632-26561632	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1763G>T; p.R588L; 1:26571859-26571859	central_nervous_system; brain	glioma	Substitution - Missense
c.321C>T; p.V107V; 1:26551410-26551410	skin	malignant_melanoma	Substitution - coding silent
c.124A>G; p.K42E; 1:26546882-26546882	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1197C>T; p.P399P; 1:26558919-26558919	skin	malignant_melanoma	Substitution - coding silent
c.1809G>T; p.L603L; 1:26571905-26571905	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.878T>C; p.L293S; 1:26555587-26555587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2044C>T; p.P682S; 1:26573320-26573320	skin	malignant_melanoma	Substitution - Missense
c.2044C>T; p.P682S; 1:26573320-26573320	skin	malignant_melanoma	Substitution - Missense
c.2044C>T; p.P682S; 1:26573320-26573320	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.924C>T; p.G308G; 1:26556661-26556661	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1044_1046delCTT; p.F349delF; 1:26557060-26557062	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.1370C>T; p.S457L; 1:26561073-26561073	breast	carcinoma	Substitution - Missense
c.1882C>T; p.R628W; 1:26572228-26572228	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.773G>A; p.G258D; 1:26555167-26555167	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1100C>G; p.P367R; 1:26558822-26558822	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.100C>T; p.P34S; 1:26536961-26536961	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1168G>A; p.D390N; 1:26558890-26558890	breast	carcinoma	Substitution - Missense
c.1070C>T; p.S357F; 1:26557086-26557086	skin	malignant_melanoma	Substitution - Missense
c.771G>A; p.T257T; 1:26555165-26555165	skin	malignant_melanoma	Substitution - coding silent
c.1588G>C; p.G530R; 1:26561661-26561661	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1706G>A; p.G569E; 1:26571564-26571564	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1357A>C; p.K453Q; 1:26561060-26561060	liver	carcinoma	Substitution - Missense
c.1398T>C; p.Y466Y; 1:26561101-26561101	thyroid	other; neoplasm	Substitution - coding silent
c.1357A>C; p.K453Q; 1:26561060-26561060	liver	carcinoma	Substitution - Missense
c.1152C>T; p.T384T; 1:26558874-26558874	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1152C>T; p.T384T; 1:26558874-26558874	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2101A>C; p.T701P; 1:26574094-26574094	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.989A>G; p.Y330C; 1:26557005-26557005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.192C>T; p.L64L; 1:26546950-26546950	skin	malignant_melanoma	Substitution - coding silent
c.1180C>T; p.R394C; 1:26558902-26558902	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1838C>T; p.P613L; 1:26572184-26572184	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.246C>T; p.V82V; 1:26547209-26547209	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1407C>T; p.H469H; 1:26561110-26561110	skin	malignant_melanoma	Substitution - coding silent
c.108G>T; p.K36N; 1:26536969-26536969	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.G199S; 1:26554233-26554233	ovary	other; neoplasm	Substitution - Missense
c.1657C>T; p.L553L; 1:26571515-26571515	skin	malignant_melanoma	Substitution - coding silent
c.770C>T; p.T257M; 1:26555164-26555164	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1544T>A; p.V515D; 1:26561617-26561617	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.559G>A; p.D187N; 1:26553481-26553481	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1097T>C; p.I366T; 1:26558819-26558819	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1798C>T; p.L600L; 1:26571894-26571894	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1798C>T; p.L600L; 1:26571894-26571894	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1529G>A; p.R510Q; 1:26561602-26561602	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1004A>C; p.K335T; 1:26557020-26557020	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.798C>T; p.D266D; 1:26555192-26555192	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1352A>T; p.K451M; 1:26561055-26561055	skin	malignant_melanoma	Substitution - Missense
c.239G>A; p.R80Q; 1:26547202-26547202	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]