| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4170 |
Name | MCL1 |
Synonymous | myeloid cell leukemia 1;MCL1;myeloid cell leukemia 1 |
Definition | bcl-2-like protein 3|bcl-2-related protein EAT/mcl1|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia ES|myeloid cell leukemia sequence 1 (BCL2-related) |
Position | 1q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Mcl-1(h) + ATP --JNK3alpha1(m){p}--> Mcl-1(h){p} + ADP (phosphorylation) | Mcl-1(h) + PCNA(h) <==> Mcl-1(h):PCNA(h) (binding) | Bax(h){pS} + Mcl-1(h) <==> Bax(h){pS}:Mcl-1(h) (binding) | Bax(m){pS184} + Mcl-1(h) <==> Bax(m){pS184}:Mcl-1(h) (binding) | Mcl-1(h) --> Mcl-1-p27(h) + protein remnants (cleavage) | Mcl-1(h) --26S proteasome(h)--> protein remnants (degradation) | Mcl-1(h) --Caspase-3(m.s.)--> protein remnants (degradation) | Mcl-1(h) --Caspase-8(m.s.)--> protein remnants (degradation) | Mcl-1(h) + Bim(h) <==> Mcl-1(h):Bim(h) (binding) | Mcl-1(h) --> Mcl-1-p24(h) + protein remnants (cleavage) | Bak(h) + Mcl-1(h) <==> Bak(h):Mcl-1(h) (binding) | Mcl-1(h) + Bak(m.s.) <==> Mcl-1(h):Bak(m.s.) (binding) | Mcl-1(h) + Noxa(m.s.) <==> Mcl-1(h):Noxa(m.s.) (binding) | Mcl-1(h) + BimS(m) <==> Mcl-1(h):BimS(m) (binding) | Mcl-1(h) + Bax(h) <==> Mcl-1(h):Bax(h) (binding) | Mcl-1(h) --Caspase(h)--> Mcl-1-p24(h) + protein remnants (cleavage) | Mcl-1(h) + tBid(h) <==> Mcl-1(h):tBid(h) (binding) | Mcl-1(h) --> PARP-p85(h) (decrease of cleavage) | Mcl-1(h) + 2 ATP --ERK1(m.s.)--> Mcl-1(h){pT92}{pT163} + 2 ADP (phosphorylation) | Mcl-1(h) + Pin1(m.s.) <==> Mcl-1(h):Pin1(m.s.) (binding) | Mcl-1(h) + Pin1(h) <==> Mcl-1(h):Pin1(h) (binding) | Mcl-1(h) + ATP --> Mcl-1(h){pS64} + ADP (phosphorylation) | Mcl-1(h) --> protein remnants (degradation) | MULE(h) + Mcl-1(h) <==> MULE(h):Mcl-1(h) (binding) | Fam(h) + Mcl-1(h) <==> Fam(h):Mcl-1(h) (binding) | Mcl-1(h) + n ubiquitin(h) --> Mcl-1(h){ub{K48}(n)} (ubiquitination) | Mcl-1(h) + n ubiquitin(h) --> Mcl-1(h){ub}n (ubiquitination) | Mcl-1(h) + ubiquitin(h) --> Mcl-1(h){ub} (ubiquitination) | Mcl-1(h) + IEX1(h) <==> Mcl-1(h):IEX1(h) (binding) | Mcl-1(h) + IEX1(h) <==> Mcl-1(h):IEX1(h) (binding) | MCL1(h) --> Mcl-1(h) (expression). | Apo2L(m.s.) --/ Mcl-1(h) (decrease of abundance) | YB-1(h) --> Mcl-1(h) (increase of abundance) | IL-3(m.s.) --> Mcl-1(h) (increase of abundance) | IL-5(m.s.) --> Mcl-1(h) (increase of abundance) | Mcl-1(h){ub} --26S proteasome(h)--> Mcl-1(h) + ubiquitin(h) (degradation) | Mcl-1L(h) + BimEL(h) <==> Mcl-1L(h):BimEL(h) (binding) | Mcl-1L(h) + BimL(h) <==> Mcl-1L(h):BimL(h) (binding) | Mcl-1L(h) + BimS(h) <==> Mcl-1L(h):BimS(h) (binding) | Mcl-1L(h) --Caspase-3(v.s.)--> protein remnants (processing) | Mcl-1L(h) --granzymeB(v.s.)--> protein remnants (processing) | Mcl-1L(h) --Caspase-3(h)--> Mcl-1L-p27(h) + protein remnants (cleavage) | Mcl-1L(h) --Caspase-3(h)--> Mcl-1L-p19(h) + protein remnants (cleavage) | Mcl-1L(h) + tBid(h) <==> Mcl-1L(h):tBid(h) (binding) | Mcl-1L(h) + Bak(m.s.) <==> Mcl-1L(h):Bak(m.s.) (binding) | Mcl-1L(h) --Caspase-3(m.s.)--> protein remnants (degradation) | Mcl-1L(h) --Caspase-8(m.s.)--> protein remnants (degradation) | MULE(h) + Mcl-1L(h) <==> MULE(h):Mcl-1L(h) (binding) | Fam(h) + Mcl-1L(h) <==> Fam(h):Mcl-1L(h) (binding) | Mcl-1L(h) + n ubiquitin(h) --> Mcl-1L(h){ub}n (ubiquitination) | Mcl-1L(h) + n ubiquitin(h) --> Mcl-1L(h){ub{k48}(n)} (ubiquitination) | Mcl-1L(h) + ubiquitin(h) --> Mcl-1L(h){ub} (ubiquitination) | Mcl-1L(h) + IEX1(h) <==> Mcl-1L(h):IEX1(h) (binding) | MCL1(h) --> Mcl-1L(h) (expression). | Mcl-1L(h){ub} --26S proteasome(h)--> Mcl-1L(h) + ubiquitin(h) (degradation) | Mcl-1S(h) + BimEL(h) <==> Mcl-1S(h):BimEL(h) (binding) | Mcl-1S(h) --Caspase-3(v.s.)--> protein remnants (processing) | Mcl-1S(h) --granzymeB(v.s.)--> protein remnants (processing) | MCL1(h) --> Mcl-1S(h) (expression). | MCL1(h) --> Mcl-1(h) (expression). | hsa-miR-29b --/ Mcl-1(h) (translational repression). | hsa-miR-512-5p --/ Mcl-1(h) (increase of mRNA decay). |
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Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 121 | Phosphoserine. | Swiss-Prot 53.0 | 163 | Phosphothreonine (by MAPK). | Swiss-Prot 53.0 | 5 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 40 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 136 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 194 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 197 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 163 | Phosphothreonine (MAPK1;MAPK3) | 15241487 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 148818260 - 148820260 | Agilent_014791 |
chr1 |
Promoter: 148818260 - 148820260 | GSE27584 |
chr1 |
Promoter: 148818260 - 148820260 | GSE27584 |
chr1 |
Promoter: 148818260 - 148820260 | Agilent_014791_44K |
chr1 |
Promoter: 148818260 - 148820260 | Agilent_014791_44K |
chr1 |
Promoter: 148818260 - 148820260 | E-GEOD-20553 |
chr1 |
Promoter: 148818260 - 148820260 | E-GEOD-20553 |