| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3717 |
Name | JAK2 |
Synonymous | Janus kinase 2;JAK2;Janus kinase 2 |
Definition | JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2 |
Position | 9p24 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | c-Kit(h) + Jak2(h) <==> c-Kit(h):Jak2(h) (binding) | Jak2(h) + ATP --> Jak2(h){pY} + ADP (phosphorylation) | Jak2(h) + STAM(h) <==> Jak2(h):STAM(h) (binding) | IL-4Ralpha(h) + Jak2(h) <==> IL-4Ralpha(h):Jak2(h) (binding) | SOCS-1(h) + Jak2(h) <==> SOCS-1(h):Jak2(h) (binding) | ErbB1(h) + Jak2(h) <==> ErbB1(h):Jak2(h) (binding) | ErbB2(h) + Jak2(h) <==> ErbB2(h):Jak2(h) (binding) | Jak2(h) + ATP --> Jak2(h){p} + ADP (phosphorylation) | IL-5Ralpha(h) + Jak2(h) <==> IL-5Ralpha(h):Jak2(h) (binding) | Jak2(h) + ATP --> Jak2(h){p} + ADP (phosphorylation; automodification) | Jak2(h) + brca1(h) <==> Jak2(h):brca1(h) (binding) | Jak2(h) + IRS-1(h) <==> Jak2(h):IRS-1(h) (binding) | Jak2(h) + 2 ATP --> Jak2(h){pY1007}{pY1008} + 2 ADP (phosphorylation) | Jak2(h) --> IL8(h) (transactivation) | IL-5Rbeta(m.s.) + Jak2(h) <==> IL-5Rbeta(m.s.):Jak2(h) (binding) | IL-5Rbeta(h) + Jak2(h) <==> IL-5Rbeta(h):Jak2(h) (binding) | Jak2(h) + PLCgamma(h) <==> Jak2(h):PLCgamma(h) (binding) | Jak2(h) + STAT1(h) <==> Jak2(h):STAT1(h) (binding) | p85(m) + Jak2(h) <==> p85(m):Jak2(h) (binding) | Jak2(h) + dynamin2(h) <==> Jak2(h):dynamin2(h) (binding) | IL-17A(h) --> Jak2(h) (activation; phosphorylation) | JAK2(h) --> Jak2(h) (expression). | IFNgamma(m.s.) --> Jak2(h) (increase of abundance) | IFNgamma(h) --> Jak2(h) (increase of abundance) | ErbB1-p170(h){pY1016} + Jak2(h) <==> ErbB1-p170(h){pY1016}:Jak2(h) (binding) | ErbB2(h){pY1023}{pY1221}{pY1222} + Jak2(h) <==> ErbB2(h){pY1023}{pY1221}{pY1222}:Jak2(h) (binding) | ErbB3-isoform1(h){pY1276} + Jak2(h) <==> ErbB3-isoform1(h){pY1276}:Jak2(h) (binding) | Jak2(h) + prlr(r) <==> Jak2(h):prlr(r) (binding) | prlr(m.s.) + Jak2(h) <==> prlr(m.s.):Jak2(h) (binding) | Jak2(h) + ATP --> Jak2(h){pY} + ADP (phosphorylation) | JAK2(h) --> Jak2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 1007 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1007 | Phosphotyrosine (JAK2) | 9111318 | Phospho.ELM 6.0 | 1008 | Phosphotyrosine (JAK2) | 11818507 | Phospho.ELM 6.0 | 813 | Phosphotyrosine | 15767667 | Phospho.ELM 6.0 | 570 | Phosphotyrosine | 16464493 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr9 |
Promoter: 4973745 - 4975745 | Agilent_014791 |
chr9 |
Promoter: 4973745 - 4975745 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 4973745 - 4975745 | GSE27584 |
chr9 |
Promoter: 4973745 - 4975745 | Agilent_014791_44K |