| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3717 |
Name | JAK2 |
Synonym | JTK10|THCYT3;Janus kinase 2;JAK2;Janus kinase 2 |
Definition | JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2 |
Position | 9p24 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | S1P3 pathway;PID Curated;200035 |
Pathway | ifn gamma signaling pathway;PID BioCarta;100138 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Interferon-gamma signaling pathway;PANTHER;P00035 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | il 3 signaling pathway;PID BioCarta;100128 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | growth hormone signaling pathway;PID BioCarta;100155 |
Pathway | epo signaling pathway;PID BioCarta;100175 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | no2-dependent il-12 pathway in nk cells;PID BioCarta;100093 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | JAK/STAT signaling pathway;PANTHER;P00038 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | il12 and stat4 dependent signaling pathway in th1 development;PID BioCarta;100133 |
Pathway | erythropoietin mediated neuroprotection through nf-kb;PID BioCarta;100176 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Pathway | IL27-mediated signaling events;PID Curated;200023 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | chaperones modulate interferon signaling pathway;PID BioCarta;100016 |
Disease | myeloproliferative neoplasms;GAD |
Disease | leukemia, myeloid;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | Leukemia, Myelomonocytic, Chronic;GAD |
Disease | Combined immunodeficiency;FunDO |
Disease | Cancer;FunDO |
Disease | Leukemia, Myeloid, Acute;GAD |
Disease | Down syndrome;FunDO |
Disease | Myeloproliferative neoplasms;NHGRI |
Disease | Myelofibrosis, idiopathic;OMIM |
Disease | Choriocarcinoma;FunDO |
Disease | Thrombocythemia, essential;OMIM |
Disease | IMMUNE;GAD |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | Rheumatoid arthritis;FunDO |
Disease | Budd-Chiari syndrome hematology indices polycythemia vera;GAD |
Disease | Polycythemia vera;KEGG DISEASE;H00012 |
Disease | Ulcerative colitis;NHGRI |
Disease | Stroke;FunDO |
Disease | Hematologic Neoplasms;GAD |
Disease | thrombocythemia;GAD |
Disease | Primary biliary cirrhosis;FunDO |
Disease | ulcerative colitis;GAD |
Disease | myelofibrosis;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | myelofibrosis myeloproliferative disorder polycythemia vera thrombocythemia;GAD |
Disease | Crohn's disease;GAD |
Disease | Polycythemia;FunDO |
Disease | Crohn's disease;NHGRI |
Disease | Budd-Chiari syndrome;OMIM |
Disease | Cancers;KEGG DISEASE |
Disease | Myeloproliferative disease;FunDO |
Disease | Primary Myelofibrosis;GAD |
Disease | Abortion;FunDO |
Disease | Polycythemia vera;OMIM |
Disease | Translocation, Genetic;GAD |
Disease | Myeloproliferative disorder with erythrocytosis;OMIM |
Disease | thromboembolism, venous;GAD |
Disease | Hematopoietic system disease;FunDO |
Disease | Thrombophilia;FunDO |
Disease | Leukemia, acute myelogenous;OMIM |
Disease | Atherosclerosis;FunDO |
External Links | |
Links to Entrez Gene | 3717 |
Links to all GeneRIF Items | 3717 |
Links to iHOP | 3717 |
Sequence Information | |
Nucleotide Sequence | >3717 : length: 5285 CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCC TCCCTCGGCGCTGACAGGCTGGGCCGGCGCCCGGCTCGCTTGGGTGTTCGCGTCGCCACT TCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGA GCCCACACTGGAGGGCCCCCGAGGGCCCAGCCTGGAGGTCGTTCAGAGCCGTGCCCGTCC CGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAA CTGTTTCTCTTCTGCAGAAAAAGAGGCTCTTCCTCCTCCTCCCGCGACGGCAAATGTTCT GAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAG ATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAGATTATCTGA CCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGT ATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTACTCTACAGAA TAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTC AGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAG CAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTG GAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTT CAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATA TACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT TTTTGACTTTTGCTGTCGAGCGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAA AAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAG ATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTA CTAAATGCTGTCCCCCAAAGCCAAAAGATAAATCAAACCTTCTAGTCTTCAGAACGAATG GTGTTTCTGATGTACCAACCTCACCAACATTACAGAGGCCTACTCATATGAACCAAATGG TGTTTCACAAAATCAGAAATGAAGATTTGATATTTAATGAAAGCCTTGGCCAAGGCACTT TTACAAAGATTTTTAAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAA CAGAAGTTCTTTTAAAAGTTCTGGATAAAGCACACAGAAACTATTCAGAGTCTTTCTTTG AAGCAGCAAGTATGATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTAT GTGTCTGTGGAGACGAGAATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATA CATATCTGAAAAAGAATAAAAATTGTATAAATATATTATGGAAACTTGAAGTTGCTAAAC AGTTGGCATGGGCCATGCATTTTCTAGAAGAAAACACCCTTATTCATGGGAATGTATGTG CCAAAAATATTCTGCTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCA AACTTAGTGATCCTGGCATTAGTATTACAGTTTTGCCAAAGGACATTCTTCAGGAGAGAA TACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACA AATGGAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTG CTCTGGATTCTCAAAGAAAGCTACAATTTTATGAAGATAGGCATCAGCTTCCTGCACCAA AGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGC CTTCTTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTAT TAACAGAAAATGACATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGGTGCCT TTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTG GCAAGGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTG GGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGACTTTG AAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAG TGTGCTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAA GTTTACGAGACTATCTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCTGCAGT ACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGG ATCTGGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTG GGTTAACCAAAGTCTTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGGTGAAA GTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAG ATGTTTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAA GTCCACCAGCGGAATTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGATCGTGT TCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAG ATGAGATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCT TTAGGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGAAAGAAAT GACCTTCATTCTGAGACCAAAGTAGATTTACAGAACAAAGTTTTATATTTCACATTGCTG TGGACTATTATTACATATATCATTATTATATAAATCATGATGCTAGCCAGCAAAGATGTG AAAATATCTGCTCAAAACTTTCAAAGTTTAGTAAGTTTTTCTTCATGAGGCCACCAGTAA AAGACATTAATGAGAATTCCTTAGCAAGGATTTTGTAAGAAGTTTCTTAAACATTGTCAG TTAACATCACTCTTGTCTGGCAAAAGAAAAAAAATAGACTTTTTCAACTCAGCTTTTTGA GACCTGAAAAAATTATTATGTAAATTTTGCAATGTTAAAGATGCACAGAATATGTATGTA TAGTTTTTACCACAGTGGATGTATAATACCTTGGCATCTTGTGTGATGTTTTACACACAT GAGGGCTGGTGTTCATTAATACTGTTTTCTAATTTTTCCATAGTTAATCTATAATTAATT ACTTCACTATACAAACAAATTAAGATGTTCAGATAATTGAATAAGTACCTTTGTGTCCTT GTTCATTTATATCGCTGGCCAGCATTATAAGCAGGTGTATACTTTTAGCTTGTAGTTCCA TGTACTGTAAATATTTTTCACATAAAGGGAACAAATGTCTAGTTTTATTTGTATAGGAAA TTTCCCTGACCCTAAATAATACATTTTGAAATGAAACAAGCTTACAAAGATATAATCTAT TTTATTATGGTTTCCCTTGTATCTATTTGTGGTGAATGTGTTTTTTAAATGGAACTATCT CCAAATTTTTCTAAGACTACTATGAACAGTTTTCTTTTAAAATTTTGAGATTAAGAATGC CAGGAATATTGTCATCCTTTGAGCTGCTGACTGCCAATAACATTCTTCGATCTCTGGGAT TTATGCTCATGAACTAAATTTAAGCTTAAGCCATAAAATAGATTAGATTGTTTTTTAAAA ATGGATAGCTCATTAAGAAGTGCAGCAGGTTAAGAATTTTTTCCTAAAGACTGTATATTT GAGGGGTTTCAGAATTTTGCATTGCAGTCATAGAAGAGATTTATTTCCTTTTTAGAGGGG AAATGAGGTAAATAAGTAAAAAAGTATGCTTGTTAATTTTATTCAAGAATGCCAGTAGAA AATTCATAACGTGTATCTTTAAGAAAAATGAGCATACATCTTAAATCTTTTCAATTAAGT ATAAGGGGTTGTTCGTTGTTGTCATTTGTTATAGTGCTACTCCACTTTAGACACCATAGC TAAAATAAAATATGGTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TGTTATTTATACAAAACTTAAAATACTTGCTGTTTTGATTAAAAAGAAAATAGTTTCTTA CTTTA |
Protein Sequence | >3717 : length: 1132 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG |