| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 328 |
Name | APEX1 |
Synonymous | APEX nuclease (multifunctional DNA repair enzyme) 1;APEX1;APEX nuclease (multifunctional DNA repair enzyme) 1 |
Definition | AP endonuclease class I|AP lyase|DNA-(apurinic or apyrimidinic site) lyase|apurinic-apyrimidinic endonuclease 1|apurinic/apyrimidinic (abasic) endonuclease|deoxyribonuclease (apurinic or apyrimidinic)|protein REF-1|redox factor-1 |
Position | 14q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Ref-1(h) + Trx1(h){reC}2 <==> Ref-1(h):Trx1(h){reC}2 (binding) | Ref-1(h) + Trx1(h){reC}2 + p53(h) <==> Ref-1(h):Trx1(h){reC}2:p53(h) (binding) | p53(h) + Ref-1(h) <==> p53(h):Ref-1(h) (binding) | c-Fos(h) + Ref-1(h) <==> c-Fos(h):Ref-1(h) (binding). | Ref-1(h) + c-Jun(r) <==> Ref-1(h):c-Jun(r) (binding) | Ref-1(h) + HIF-1alpha(h) <==> Ref-1(h):HIF-1alpha(h) (binding) | Ref-1(h) + ATP --CKII(v.s.)--> Ref-1(h){p} + ADP (phosphorylation) | MYH(h) + Ref-1(h) <==> MYH(h):Ref-1(h) (binding) | MYH-alpha3(h) + Ref-1(h) <==> MYH-alpha3(h):Ref-1(h) (binding) | UDG-isoform2(h) + Ref-1(h) <==> UDG-isoform2(h):Ref-1(h) (binding) | PCNA(h) + Ref-1(h) <==> PCNA(h):Ref-1(h) (binding) | Ref-1(h) --> SCT(r) (DNA binding). | APEX1(h) --> Ref-1(h) (expression). | p53(h) --Ref-1(h)--> p53(h){re} (redox reaction) | Ref-1(h) --> PTH(h) (DNA binding). | MYH-alpha3(h) + Ref-1(h) <==> MYH-alpha3(h):Ref-1(h) (binding) | Ref-1(h) + FEN1(h) <==> Ref-1(h):FEN1(h) (binding) | PCNA(m.s.) + Ref-1(h) <==> PCNA(m.s.):Ref-1(h) (binding) | PCNA(h) + Ref-1(h) <==> PCNA(h):Ref-1(h) (binding) | MVP(h) + Ref-1(h) <==> MVP(h):Ref-1(h) (binding) | Ref-1(h) --> ABCB1(h) (DNA binding; transactivation). | APEX1(h) --> Ref-1(h) (expression). | APEX1(h) --> APEX1_1(h) (expression). | hsa-let-7a --/ APEX1_1(h) (predicted) | hsa-let-7b --/ APEX1_1(h) (predicted) | hsa-let-7c --/ APEX1_1(h) (predicted) | hsa-let-7d --/ APEX1_1(h) (predicted) | hsa-let-7e --/ APEX1_1(h) (predicted) | hsa-let-7f --/ APEX1_1(h) (predicted) | APEX1(h) --> APEX1_2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 262 | Phosphotyrosine. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr14 |
Promoter: 19991630 - 19993630 | GSE27584 |
chr14 |
Promoter: 19991630 - 19993630 | GSE27584 |
chr14 |
Promoter: 19991630 - 19993630 | GSE27584 |
chr14 |
Promoter: 19991630 - 19993630 | Agilent_014791_44K |
chr14 |
Promoter: 19991630 - 19993630 | Agilent_014791 |