| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 328 |
Name | APEX1 |
Synonymous | APEX nuclease (multifunctional DNA repair enzyme) 1;APEX1;APEX nuclease (multifunctional DNA repair enzyme) 1 |
Definition | AP endonuclease class I|AP lyase|DNA-(apurinic or apyrimidinic site) lyase|apurinic-apyrimidinic endonuclease 1|apurinic/apyrimidinic (abasic) endonuclease|deoxyribonuclease (apurinic or apyrimidinic)|protein REF-1|redox factor-1 |
Position | 14q11.2 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
FEN1 | REACTOME; |
in same component |
LIG1 | REACTOME; |
in same component |
POLB | REACTOME; |
in same component |
POLD1 | REACTOME; |
in same component |
POLD2 | REACTOME; |
in same component |
POLD3 | REACTOME; |
in same component |
POLD4 | REACTOME; |
interacts with |
ANP32A | BIOGRID; |
interacts with |
EP300 | INTACT; |
interacts with |
FEN1 | BIOGRID; |
interacts with |
HIF1A | BIOGRID; |
interacts with |
HNRNPL | BIOGRID; |
interacts with |
HOXC13 | BIOGRID; |
interacts with |
MUTYH | BIOGRID; |
interacts with |
PCNA | BIOGRID; |
interacts with |
POLR3D | BIOGRID; |
interacts with |
SET | BIOGRID; |
interacts with |
TCF21 | BIOGRID; |
interacts with |
TP53 | BIOGRID; |
interacts with |
XRCC1 | BIOGRID; |
interacts with |
XRCC5 | BIOGRID; |
interacts with |
YBX1 | INTACT; |
Metabolic Interaction [Top] | ||
There is no record for APEX1 | ||
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
APEX1 | REACTOME; |
reacts with |
CCNO | REACTOME; |
reacts with |
FEN1 | REACTOME; |
reacts with |
LIG1 | REACTOME; |
reacts with |
MPG | REACTOME; |
reacts with |
MUTYH | REACTOME; |
reacts with |
NTHL1 | REACTOME; |
reacts with |
OGG1 | REACTOME; |
reacts with |
POLB | REACTOME; |
reacts with |
POLD1 | REACTOME; |
reacts with |
POLD2 | REACTOME; |
reacts with |
POLD3 | REACTOME; |
reacts with |
POLD4 | REACTOME; |
reacts with |
SMUG1 | REACTOME; |
reacts with |
TDG | REACTOME; |
state change |
APEX1 | REACTOME; |
state change |
FEN1 | REACTOME; |
state change |
POLB | REACTOME; |
state change |
POLD1 | REACTOME; |
state change |
POLD2 | REACTOME; |
state change |
POLD3 | REACTOME; |
state change |
POLD4 | REACTOME; |