| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 328 |
Name | APEX1 |
Synonym | APE|APE1|APEN|APEX|APX|HAP1|REF1;APEX nuclease (multifunctional DNA repair enzyme) 1;APEX1;APEX nuclease (multifunctional DNA repair enzyme) 1 |
Definition | AP endonuclease class I|AP lyase|DNA-(apurinic or apyrimidinic site) lyase|apurinic-apyrimidinic endonuclease 1|apurinic/apyrimidinic (abasic) endonuclease|deoxyribonuclease (apurinic or apyrimidinic)|protein REF-1|redox factor-1 |
Position | 14q11.2 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | granzyme a mediated apoptosis pathway;PID BioCarta;100035 |
Pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PID Reactome;500033 |
Pathway | Base excision repair;KEGG PATHWAY;hsa03410 |
Pathway | Base-free sugar-phosphate removal via the single-nucleotide replacement pathway;PID Reactome;500984 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | Removal of DNA patch containing abasic residue;PID Reactome;500945 |
Pathway | Displacement of DNA glycosylase by APE1;PID Reactome;501000 |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | radiotherapy;GAD |
Disease | DNA repair;GAD |
Disease | lung cancer;GAD |
Disease | radiotherapy response;GAD |
Disease | prostate cancer;GAD |
Disease | CANCER;GAD |
Disease | Cockayne syndrome;FunDO |
Disease | Cancer;FunDO |
Disease | radiotherapy sensitivity;GAD |
Disease | Stroke;FunDO |
Disease | melanoma;GAD |
Disease | upper aerodigestive tract cancer;GAD |
External Links | |
Links to Entrez Gene | 328 |
Links to all GeneRIF Items | 328 |
Links to iHOP | 328 |
Sequence Information | |
Nucleotide Sequence | >328 : length: 1563 CAGACAGACCAATCACGCGCATTCTTCGGCCACGACAAGCGCGCCTCTGATCACGTGACC AGGTCCGCTACCCACGTGGGGGCTCAGCGTGCACCCTTCTTTGTGCTCGGGTTAGGAGGA GCTAGGCTGCCATCGGGCCGGTGCAGATACGGGGTTGCTCTTTTGCTCATAAGAGGGGCT TCGCTGGCAGTCTGAACGGCAAGCTTGAGTCAGGACCCTTAATTAAGATCCTCAATTGGC TGGAGGGCAGATCTCGCGAGTAGGGCAACGCGGTAAAAATATTGCTTCGGTGGGTGACGC GGTACAGCTGCCCAAGGGCGTTCGTAACGGGAATGCCGAAGCGTGGGAAAAAGGGAGCGG TGGCGGAAGACGGGGATGAGCTCAGGACAGAGCCAGAGGCCAAGAAGAGTAAGACGGCCG CAAAGAAAAATGACAAAGAGGCAGCAGGAGAGGGCCCAGCCCTGTATGAGGACCCCCCAG ATCAGAAAACCTCACCCAGTGGCAAACCTGCCACACTCAAGATCTGCTCTTGGAATGTGG ATGGGCTTCGAGCCTGGATTAAGAAGAAAGGATTAGATTGGGTAAAGGAAGAAGCCCCAG ATATACTGTGCCTTCAAGAGACCAAATGTTCAGAGAACAAACTACCAGCTGAACTTCAGG AGCTGCCTGGACTCTCTCATCAATACTGGTCAGCTCCTTCGGACAAGGAAGGGTACAGTG GCGTGGGCCTGCTTTCCCGCCAGTGCCCACTCAAAGTTTCTTACGGCATAGGCGATGAGG AGCATGATCAGGAAGGCCGGGTGATTGTGGCTGAATTTGACTCGTTTGTGCTGGTAACAG CATATGTACCTAATGCAGGCCGAGGTCTGGTACGACTGGAGTACCGGCAGCGCTGGGATG AAGCCTTTCGCAAGTTCCTGAAGGGCCTGGCTTCCCGAAAGCCCCTTGTGCTGTGTGGAG ACCTCAATGTGGCACATGAAGAAATTGACCTTCGCAACCCCAAGGGGAACAAAAAGAATG CTGGCTTCACGCCACAAGAGCGCCAAGGCTTCGGGGAATTACTGCAGGCTGTGCCACTGG CTGACAGCTTTAGGCACCTCTACCCCAACACACCCTATGCCTACACCTTTTGGACTTATA TGATGAATGCTCGATCCAAGAATGTTGGTTGGCGCCTTGATTACTTTTTGTTGTCCCACT CTCTGTTACCTGCATTGTGTGACAGCAAGATCCGTTCCAAGGCCCTCGGCAGTGATCACT GTCCTATCACCCTATACCTAGCACTGTGACACCACCCCTAAATCACTTTGAGCCTGGGAA ATAAGCCCCCTCAACTACCATTCCTTCTTTAAACACTCTTCAGAGAAATCTGCATTCTAT TTCTCATGTATAAAACTAGGAATCCTCCAACCAGGCTCCTGTGATAGAGTTCTTTTAAGC CCAAGATTTTTTATTTGAGGGTTTTTTGTTTTTTAAAAAAAAATTGAACAAAGACTACTA ATGACTTTGTTTGAATTATCCACATGAAAATAAAGAGCCATAGTTTCAGCCTTAAAAAAA AAA |
Protein Sequence | >328 : length: 318 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI RSKALGSDHCPITLYLAL |