| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1019 |
Name | CDK4 |
Synonymous | cyclin-dependent kinase 4;CDK4;cyclin-dependent kinase 4 |
Definition | cell division protein kinase 4 |
Position | 12q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | cyclinD(h) + Cdk4(h) <==> cyclinD(h):Cdk4(h) (binding) | Cdk4(h) + p16INK4a(h) <==> Cdk4(h):p16INK4a(h) (binding) | Cdk4(h) + p18INK4c(h) <==> Cdk4(h):p18INK4c(h) (binding) | Cdk4(h) + p21Cip1(h) <==> Cdk4(h):p21Cip1(h) (binding) | Cdk4(h) + p27Kip1(h) <==> Cdk4(h):p27Kip1(h) (binding) | Hsp50(h) + Cdk4(h) <==> Hsp50(h):Cdk4(h) (binding) | Hsp90(h) + Cdk4(h) <==> Hsp90(h):Cdk4(h) (binding) | Cdk4(h) + p34SEI-1(h) <==> Cdk4(h):p34SEI-1(h) (binding) | cyclinD1(h) + Cdk4(h) + p16INK4a(h) + p34SEI-1(h) <==> cyclinD1(h):Cdk4(h):p16INK4a(h):p34SEI-1(h) (binding) | Cdk4(h) + 14-3-3sigma(m) <==> Cdk4(h):14-3-3sigma(m) (binding) | cyclinD1(h) + Cdk4(h) + p21Cip1(h) <==> cyclinD1(h):Cdk4(h):p21Cip1(h) (binding) | Cdk4(h) + p15INK4b(h) <==> Cdk4(h):p15INK4b(h) (binding) | calmodulin(v.s.):calcineurin(b) + Cdk4(h) <==> calmodulin(v.s.):calcineurin(b):Cdk4(h) (binding) | CnAalpha(h) + Cdk4(h) <==> CnAalpha(h):Cdk4(h) (binding) | Cdk4(h) + brca1(h) <==> Cdk4(h):brca1(h) (binding) | Cdk4(h) + C/EBPalpha(h) <==> Cdk4(h):C/EBPalpha(h) (binding) | p27Kip1(h) + cyclinD1(h) + Cdk4(h) <==> p27Kip1(h):cyclinD1(h):Cdk4(h) (binding) | Cdk4(h) + cyclinD1a(h) <==> Cdk4(h):cyclinD1a(h) (binding) | Hsp50(h) + Cdk4(h) + Hsp90(h) <==> Hsp50(h):Cdk4(h):Hsp90(h) (binding) | OGG1-1A(h){pS}{pT} + Cdk4(h) <==> OGG1-1A(h){pS}{pT}:Cdk4(h) (binding) | Cdk4(h) + p16INK4a(h) <==> Cdk4(h):p16INK4a(h) (binding) | Cdk4(h) + p15INK4b(m.s.) <==> Cdk4(h):p15INK4b(m.s.) (binding) | Cdk4(h) + p16INK4a(m.s.) <==> Cdk4(h):p16INK4a(m.s.) (binding) | reprimo(h) + Cdk4(h) <==> reprimo(h):Cdk4(h) (binding) | ARP3-beta(h) + Cdk4(h) <==> ARP3-beta(h):Cdk4(h) (binding) | HIP-55(h) + Cdk4(h) <==> HIP-55(h):Cdk4(h) (binding) | Cdk4(h) + SMC-3(h) <==> Cdk4(h):SMC-3(h) (binding) | Cdk4(h) + Gemin-4(h) <==> Cdk4(h):Gemin-4(h) (binding) | Cdk4(h) + SAPKS1(h) <==> Cdk4(h):SAPKS1(h) (binding) | Cdk4(h) + SMC1(h) <==> Cdk4(h):SMC1(h) (binding) | Cdk4(h) + Lyn(h) <==> Cdk4(h):Lyn(h) (binding) | cyclinD3(h) + Cdk4(h) <==> cyclinD3(h):Cdk4(h) (binding) | Cdk4(h) + p19INK4d(h) <==> Cdk4(h):p19INK4d(h) (binding) | Cdk4(h) + My012(h) <==> Cdk4(h):My012(h) (binding) | Cdk4(h) + calpain-4(h) <==> Cdk4(h):calpain-4(h) (binding) | Cdk4(h) + protein G3(h) <==> Cdk4(h):protein G3(h) (binding) | Cdk4(h) + ESET(h) <==> Cdk4(h):ESET(h) (binding) | CDK4(h) --> Cdk4(h) (expression). | Cdk4(h){pT172} --calmodulin(v.s.):calcineurin(b)--> Cdk4(h) + p (dephosphorylation) | C/EBPalpha(h) --/ Cdk4(h) (decrease of abundance) | Smad3(h) + 3 ATP --Cdk4(h)--> Smad3(h){pT8}{pT178}{pS212} + 3 ADP (phosphorylation) | Smad3(m.s.) + 3 ATP --Cdk4(h)--> Smad3(m.s.){pT8}{pT178}{pS212} + 3 ADP (phosphorylation) | OGG1-1A(h) + ATP --Cdk4(h)--> OGG1-1A(h){p} + ADP (phosphorylation) | Cdk4(h) + cyclinD3(h) <==> Cdk4(h):cyclinD3(h) (binding) | cyclinD1(h) + Cdk4(h) <==> cyclinD1(h):Cdk4(h) (binding) | p21Cip1(h) + Cdk4(h) <==> p21Cip1(h):Cdk4(h) (binding) | p15INK4b(h) + Cdk4(h) <==> p15INK4b(h):Cdk4(h) (binding) | p27Kip1(h) + Cdk4(h) <==> p27Kip1(h):Cdk4(h) (binding) | CDK4(h) --> Cdk4(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 172 | Phosphothreonine (by CAK) (Bysimilarity). | Swiss-Prot 53.0 | 172 | Phosphothreonine (CDK7) | 8139570 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 56431931 - 56433931 | GSE27584 |
chr12 |
Promoter: 56431931 - 56433931 | Agilent_014791 |