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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

1019

Name

CDK4

Synonymous

cyclin-dependent kinase 4;CDK4;cyclin-dependent kinase 4

Definition

cell division protein kinase 4

Position

12q14

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ATMREACTOME;

in same component

 BLMREACTOME;

in same component

 BRCA1REACTOME;

in same component

 BRCA2REACTOME;

in same component

 CCND1CELL_MAP;

in same component

 CCND1NCI_NATURE;

in same component

 CCND1REACTOME;

in same component

 CDK6CELL_MAP;

in same component

 DMC1REACTOME;

in same component

 H2AFXREACTOME;

in same component

 HIST3H3REACTOME;

in same component

 MSH4REACTOME;

in same component

 MSH5REACTOME;

in same component

 RAD51REACTOME;

in same component

 RPA1REACTOME;

in same component

 RPA2REACTOME;

in same component

 RPA3REACTOME;

in same component

 TOP3AREACTOME;

interacts with

 ACTR3BBIOGRID;

interacts with

 BAG6BIOGRID;

interacts with

 BAG6HPRD;

interacts with

 BIRC5BIOGRID;

interacts with

 BIRC5HPRD;

interacts with

 BMPR1BHPRD;

interacts with

 BRCA1BIOGRID;

interacts with

 CAPNS1BIOGRID;

interacts with

 CAPNS1HPRD;

interacts with

 CCND1BIOGRID;

interacts with

 CCND1HPRD;

interacts with

 CCND1MINT;

interacts with

 CCND2BIOGRID;

interacts with

 CCND2HPRD;

interacts with

 CCND3BIOGRID;

interacts with

 CCND3HPRD;

interacts with

 CCND3MINT;

interacts with

 CDC37BIOGRID;

interacts with

 CDC37HPRD;

interacts with

 CDC45HPRD;

interacts with

 CDC7HPRD;

interacts with

 CDC7MINT;

interacts with

 CDK6HPRD;

interacts with

 CDKN1ABIOGRID;

interacts with

 CDKN1AHPRD;

interacts with

 CDKN1AMINT;

interacts with

 CDKN1BBIOGRID;

interacts with

 CDKN1BHPRD;

interacts with

 CDKN1BMINT;

interacts with

 CDKN1CHPRD;

interacts with

 CDKN2ABIOGRID;

interacts with

 CDKN2AHPRD;

interacts with

 CDKN2BBIOGRID;

interacts with

 CDKN2BHPRD;

interacts with

 CDKN2CBIOGRID;

interacts with

 CDKN2CHPRD;

interacts with

 CDKN2DBIOGRID;

interacts with

 CDKN2DHPRD;

interacts with

 CDT1BIOGRID;

interacts with

 CEBPABIOGRID;

interacts with

 CEBPAHPRD;

interacts with

 CNOT7BIOGRID;

interacts with

 CNOT7HPRD;

interacts with

 DBNLBIOGRID;

interacts with

 DHX9HPRD;

interacts with

 GEMIN4BIOGRID;

interacts with

 HSP82BIOGRID;

interacts with

 HSPA8BIOGRID;

interacts with

 LYNBIOGRID;

interacts with

 MCM2HPRD;

interacts with

 MCM2MINT;

interacts with

 MYOD1BIOGRID;

interacts with

 MYOD1HPRD;

interacts with

 NCOA2BIOGRID;

interacts with

 NCOA2HPRD;

interacts with

 NOL12HPRD;

interacts with

 ORC3HPRD;

interacts with

 PCNABIOGRID;

interacts with

 PCNAHPRD;

interacts with

 PPP2R1BHPRD;

interacts with

 PRKAR1AHPRD;

interacts with

 PRMT5BIOGRID;

interacts with

 PSMD10HPRD;

interacts with

 RB1BIOGRID;

interacts with

 RB1HPRD;

interacts with

 RBL1HPRD;

interacts with

 RBL2HPRD;

interacts with

 RFC1BIOGRID;

interacts with

 RFC1HPRD;

interacts with

 RFC4HPRD;

interacts with

 RPA1HPRD;

interacts with

 RPRMBIOGRID;

interacts with

 RUNX2BIOGRID;

interacts with

 SAP25BIOGRID;

interacts with

 SERTAD1BIOGRID;

interacts with

 SETDB1BIOGRID;

interacts with

 SETDB1HPRD;

interacts with

 SMAD2HPRD;

interacts with

 SMC1ABIOGRID;

interacts with

 SMC3BIOGRID;

interacts with

 SP1BIOGRID;

interacts with

 TOP1HPRD;

interacts with

 TSPYL2BIOGRID;

interacts with

 UBXN1BIOGRID;

interacts with

 VTA1BIOGRID;

interacts with

 VTA1HPRD;

interacts with

 WDR77BIOGRID;

interacts with

 ZNF655HPRD;

interacts with

 ZNF655MINT;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 ATF2NCI_NATURE;

metabolic catalysis

 E2F1NCI_NATURE;

metabolic catalysis

 JUNDNCI_NATURE;

metabolic catalysis

 KAT2ANCI_NATURE;

metabolic catalysis

 MAXNCI_NATURE;

metabolic catalysis

 MYCNCI_NATURE;

metabolic catalysis

 SUPT3HNCI_NATURE;

metabolic catalysis

 SUPT7LNCI_NATURE;

metabolic catalysis

 TAF10NCI_NATURE;

metabolic catalysis

 TAF12NCI_NATURE;

metabolic catalysis

 TAF9NCI_NATURE;

metabolic catalysis

 TRRAPNCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 ATMREACTOME;

reacts with

 BLMREACTOME;

reacts with

 BRCA1REACTOME;

reacts with

 BRCA2REACTOME;

reacts with

 CCND1REACTOME;

reacts with

 CDK2REACTOME;

reacts with

 CDK4REACTOME;

reacts with

 DMC1REACTOME;

reacts with

 H2AFXREACTOME;

reacts with

 HIST3H3REACTOME;

reacts with

 MLH1REACTOME;

reacts with

 MLH3REACTOME;

reacts with

 MSH4REACTOME;

reacts with

 MSH5REACTOME;

reacts with

 RAD51REACTOME;

reacts with

 RPA1REACTOME;

reacts with

 RPA2REACTOME;

reacts with

 RPA3REACTOME;

reacts with

 TOP3AREACTOME;

state change

 ATMREACTOME;

state change

 BRCA1REACTOME;

state change

 BRCA2REACTOME;

state change

 CDK4REACTOME;

state change

 DMC1REACTOME;

state change

 H2AFXREACTOME;

state change

 HIST3H3REACTOME;

state change

 MND1REACTOME;

state change

 PSMC3IPREACTOME;

state change

 RAD51CREACTOME;

state change

 RAD51REACTOME;

state change

 RPA1REACTOME;

state change

 RPA2REACTOME;

state change

 RPA3REACTOME;

state change

 TEX15REACTOME;

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