| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1019 |
Name | CDK4 |
Synonym | CMM3|PSK-J3;cyclin-dependent kinase 4;CDK4;cyclin-dependent kinase 4 |
Definition | cell division protein kinase 4 |
Position | 12q14 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | Cyclin D associated events in G1;PID Reactome;500897 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | p53 signaling pathway;PID BioCarta;100083 |
Pathway | Ubiquitin-dependent degradation of Cyclin D1;PID Reactome;501007 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Cancers;KEGG DISEASE |
Disease | Cervical cancer;KEGG DISEASE;H00030 |
Disease | Malignant melanoma;KEGG DISEASE;H00038 |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | Melanoma;OMIM |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Skin cancers;KEGG DISEASE |
External Links | |
Links to Entrez Gene | 1019 |
Links to all GeneRIF Items | 1019 |
Links to iHOP | 1019 |
Sequence Information | |
Nucleotide Sequence | >1019 : length: 2020 CACCTCCTGTCCGCCCCTCAGCGCATGGGTGGCGGTCACGTGCCCAGAACGTCCGGCGTT CGCCCCGCCCTCCCAGTTTCCGCGCGCCTCTTTGGCAGCTGGTCACATGGTGAGGGTGGG GGTGAGGGGGCCTCTCTAGCTTGCGGCCTGTGTCTATGGTCGGGCCCTCTGCGTCCAGCT GCTCCGGACCGAGCTCGGGTGTATGGGGCCGTAGGAACCGGCTCCGGGGCCCCGATAACG GGCCGCCCCCACAGCACCCCGGGCTGGCGTGAGGGTCTCCCTTGATCTGAGAATGGCTAC CTCTCGATATGAGCCAGTGGCTGAAATTGGTGTCGGTGCCTATGGGACAGTGTACAAGGC CCGTGATCCCCACAGTGGCCACTTTGTGGCCCTCAAGAGTGTGAGAGTCCCCAATGGAGG AGGAGGTGGAGGAGGCCTTCCCATCAGCACAGTTCGTGAGGTGGCTTTACTGAGGCGACT GGAGGCTTTTGAGCATCCCAATGTTGTCCGGCTGATGGACGTCTGTGCCACATCCCGAAC TGACCGGGAGATCAAGGTAACCCTGGTGTTTGAGCATGTAGACCAGGACCTAAGGACATA TCTGGACAAGGCACCCCCACCAGGCTTGCCAGCCGAAACGATCAAGGATCTGATGCGCCA GTTTCTAAGAGGCCTAGATTTCCTTCATGCCAATTGCATCGTTCACCGAGATCTGAAGCC AGAGAACATTCTGGTGACAAGTGGTGGAACAGTCAAGCTGGCTGACTTTGGCCTGGCCAG AATCTACAGCTACCAGATGGCACTTACACCCGTGGTTGTTACACTCTGGTACCGAGCTCC CGAAGTTCTTCTGCAGTCCACATATGCAACACCTGTGGACATGTGGAGTGTTGGCTGTAT CTTTGCAGAGATGTTTCGTCGAAAGCCTCTCTTCTGTGGAAACTCTGAAGCCGACCAGTT GGGCAAAATCTTTGACCTGATTGGGCTGCCTCCAGAGGATGACTGGCCTCGAGATGTATC CCTGCCCCGTGGAGCCTTTCCCCCCAGAGGGCCCCGCCCAGTGCAGTCGGTGGTACCTGA GATGGAGGAGTCGGGAGCACAGCTGCTGCTGGAAATGCTGACTTTTAACCCACACAAGCG AATCTCTGCCTTTCGAGCTCTGCAGCACTCTTATCTACATAAGGATGAAGGTAATCCGGA GTGAGCAATGGAGTGGCTGCCATGGAAGGAAGAAAAGCTGCCATTTCCCTTCTGGACACT GAGAGGGCAATCTTTGCCTTTATCTCTGAGGCTATGGAGGGTCCTCCTCCATCTTTCTAC AGAGATTACTTTGCTGCCTTAATGACATTCCCCTCCCACCTCTCCTTTTGAGGCTTCTCC TTCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCTCTTGTCCCTTTCCCTACCTT TATATTTGGGGTCCTTTTTTATACAGGAAAAACAAAACAAAGAAATAATGGTCTTTTTTT TTTTTTTAATGTTTCTTCCTCTGTTTGGCTTTGCCATTGTGCGATTTGGAAAAACCACTT GGAAGAAGGGACTTTCCTGCAAAACCTTAAAGACTGGTTAAATTACAGGGCCTAGGAAGT CAGTGGAGCCCCTTGACTGACAAAGCTTAGAAAGGAACTGAAATTGCTTCTTTGAATATG GATTTTAGGCGGGGCGTGGTGGCTCACGCCTATAATCCCAGCACGTTGGGAGGCCAACGC GGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACTAACATGGTGAAACCCTGT CTCTACTAAAAATACAAAATTAGTCAGGCGTGGTGGTGCACACCTGTAATCCCAGCTACT TGGGAGACTGAGGCAGGAGGATCGCTTGAACCCGGGAGGCAGAGGTTGCGGTGAGCCGAG ATCATGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTGTCAAAAAAAAAAAA AGAATATAGATTTTTAAATGGCAAAAAAAAAAAAAAAAAA |
Protein Sequence | >1019 : length: 303 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG NPE |