Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5594

Name

MAPK1

Synonymous

mitogen-activated protein kinase 1;MAPK1;mitogen-activated protein kinase 1

Definition

MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2

Position

22q11.21

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.220_221insA; p.I74fs*8; 22:21807745-21807746

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.471C>A; p.L157L; 22:21805871-21805871

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.442C>A; p.R148S; 22:21805900-21805900

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.515G>A; p.R172H; 22:21799106-21799106

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.955C>T; p.P319S; 22:21772884-21772884

 skinmalignant_melanomaSubstitution - Missense

c.429T>C; p.A143A; 22:21805913-21805913

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.962A>T; p.D321V; 22:21772877-21772877

 skinmalignant_melanomaSubstitution - Missense

c.120-10_120-9delCT; p.?; 22:21807855-21807856

 skinmalignant_melanomaUnknown

c.797C>T; p.S266F; 22:21788316-21788316

 skinmalignant_melanomaSubstitution - Missense

c.229C>T; p.R77C; 22:21807737-21807737

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.571C>T; p.R191C; 22:21799050-21799050

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.725-1G>A; p.?; 22:21788389-21788389

 skinmalignant_melanomaUnknown

c.51G>A; p.Q17Q; 22:21867390-21867390

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.770A>G; p.N257S; 22:21788343-21788343

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.947A>T; p.Y316F; 22:21772892-21772892

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1033G>T; p.E345*; 22:21769254-21769254

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.837C>T; p.F279F; 22:21788276-21788276

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.485A>G; p.D162G; 22:21805857-21805857

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.542_543delCA; p.T181fs*29; 22:21799078-21799079

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.868T>C; p.L290L; 22:21772971-21772971

 breastcarcinomaSubstitution - coding silent

c.965A>T; p.E322V; 22:21772874-21772874

 livercarcinomaSubstitution - Missense

c.965A>T; p.E322V; 22:21772874-21772874

 livercarcinomaSubstitution - Missense

c.20_22delCGG; p.A7delA; 22:21867419-21867421

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.803C>T; p.P268L; 22:21788310-21788310

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.484G>A; p.D162N; 22:21805858-21805858

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.500A>G; p.D167G; 22:21799121-21799121

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.781A>G; p.R261G; 22:21788332-21788332

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.832C>T; p.L278L; 22:21788281-21788281

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1053T>G; p.T351T; 22:21769234-21769234

 livercarcinomaSubstitution - coding silent

c.471C>G; p.L157L; 22:21805871-21805871

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.961G>A; p.D321N; 22:21772878-21772878

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.961G>A; p.D321N; 22:21772878-21772878

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.517G>A; p.V173I; 22:21799104-21799104

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.204C>T; p.T68T; 22:21807762-21807762

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.204C>T; p.T68T; 22:21807762-21807762

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.428C>A; p.A143D; 22:21805914-21805914

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.820C>T; p.P274S; 22:21788293-21788293

 pancreascarcinomaSubstitution - Missense

c.892C>A; p.P298T; 22:21772947-21772947

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.425C>T; p.S142L; 22:21805917-21805917

 skinmalignant_melanomaSubstitution - Missense

c.429T>A; p.A143A; 22:21805913-21805913

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.361C>A; p.L121I; 22:21805981-21805981

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.154G>T; p.A52S; 22:21807812-21807812

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.788A>G; p.Y263C; 22:21788325-21788325

 central_nervous_system; braingliomaSubstitution - Missense

c.432C>T; p.N144N; 22:21805910-21805910

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.548T>C; p.F183S; 22:21799073-21799073

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.129T>C; p.Y43Y; 22:21807837-21807837

 thyroidother; neoplasmSubstitution - coding silent

c.572G>A; p.R191H; 22:21799049-21799049

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.173C>T; p.P58L; 22:21807793-21807793

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.572G>A; p.R191H; 22:21799049-21799049

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.685C>T; p.P229S; 22:21788733-21788733

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.285C>T; p.I95I; 22:21807681-21807681

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.800T>C; p.L267P; 22:21788313-21788313

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.872A>G; p.D291G; 22:21772967-21772967

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.526C>T; p.P176S; 22:21799095-21799095

 skinmalignant_melanomaSubstitution - Missense

c.730C>T; p.L244F; 22:21788383-21788383

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.188C>T; p.T63I; 22:21807778-21807778

 skin; abdomenmalignant_melanomaSubstitution - Missense

c.730C>T; p.L244F; 22:21788383-21788383

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.785A>C; p.N262T; 22:21788328-21788328

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.241G>A; p.E81K; 22:21807725-21807725

 breastcarcinomaSubstitution - Missense

c.730C>A; p.L244I; 22:21788383-21788383

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.407G>A; p.G136E; 22:21805935-21805935

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.993C>T; p.F331F; 22:21769294-21769294

 skinmalignant_melanomaSubstitution - coding silent

c.737C>T; p.S246F; 22:21788376-21788376

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.964G>A; p.E322K; 22:21772875-21772875

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.964G>A; p.E322K; 22:21772875-21772875

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.964G>A; p.E322K; 22:21772875-21772875

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.964G>A; p.E322K; 22:21772875-21772875

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.964G>A; p.E322K; 22:21772875-21772875

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.964G>A; p.E322K; 22:21772875-21772875

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.704A>T; p.D235V; 22:21788714-21788714

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.600G>T; p.L200F; 22:21799021-21799021

 pancreascarcinomaSubstitution - Missense

c.600G>T; p.L200F; 22:21799021-21799021

 pancreascarcinomaSubstitution - Missense

c.600G>T; p.L200F; 22:21799021-21799021

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

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