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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5594

Name

MAPK1

Synonymous

mitogen-activated protein kinase 1;MAPK1;mitogen-activated protein kinase 1

Definition

MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2

Position

22q11.21

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 AP2B1REACTOME;

in same component

 AP2M1REACTOME;

in same component

 AP2S1REACTOME;

in same component

 CAPN2NCI_NATURE;

in same component

 CNKSR1IMID;

in same component

 L1CAMREACTOME;

in same component

 LAMTOR3IMID;

in same component

 MAP2K2REACTOME;

in same component

 SH3GL2REACTOME;

interacts with

 ACADVLINTACT;

interacts with

 ACBD5INTACT;

interacts with

 ACP1INTACT;

interacts with

 ACSL3INTACT;

interacts with

 ACSL5INTACT;

interacts with

 ACTBINTACT;

interacts with

 ADAM17BIOGRID;

interacts with

 ADAP1INTACT;

interacts with

 ADD1INTACT;

interacts with

 ADD3INTACT;

interacts with

 ADRB2HPRD;

interacts with

 AGPSINTACT;

interacts with

 AGTR1HPRD;

interacts with

 AHNAKINTACT;

interacts with

 AIPINTACT;

interacts with

 AKT1HPRD;

interacts with

 AKT1INTACT;

interacts with

 ALDH1B1INTACT;

interacts with

 ALKBIOGRID;

interacts with

 AP1B1INTACT;

interacts with

 AP2B1INTACT;

interacts with

 AP3S1INTACT;

interacts with

 ARCN1INTACT;

interacts with

 ARF4INTACT;

interacts with

 ARHGAP1INTACT;

interacts with

 ARHGAP8INTACT;

interacts with

 ARHGEF2BIOGRID;

interacts with

 ARL1INTACT;

interacts with

 ARBIOGRID;

interacts with

 ARHPRD;

interacts with

 ARRB1HPRD;

interacts with

 ARRB2BIOGRID;

interacts with

 ARRB2HPRD;

interacts with

 ATF2BIOGRID;

interacts with

 ATP1A1BIOGRID;

interacts with

 ATP1A1INTACT;

interacts with

 AVPR2HPRD;

interacts with

 B3GAT3INTACT;

interacts with

 BCL2HPRD;

interacts with

 BCL2MINT;

interacts with

 BLNKHPRD;

interacts with

 BTKHPRD;

interacts with

 BZW1INTACT;

interacts with

 BZW2INTACT;

interacts with

 C1QBPBIOGRID;

interacts with

 C1QBPHPRD;

interacts with

 CADHPRD;

interacts with

 CALCOCO1HPRD;

interacts with

 CAPZA1INTACT;

interacts with

 CAPZBINTACT;

interacts with

 CASP8HPRD;

interacts with

 CASP8MINT;

interacts with

 CASP9BIOGRID;

interacts with

 CASP9CELL_MAP;

interacts with

 CASP9HPRD;

interacts with

 CAV1CELL_MAP;

interacts with

 CAV1HPRD;

interacts with

 CCND1BIOGRID;

interacts with

 CD19HPRD;

interacts with

 CD9INTACT;

interacts with

 CDC25CBIOGRID;

interacts with

 CDH1INTACT;

interacts with

 CDK1INTACT;

interacts with

 CDX2HPRD;

interacts with

 CEBPBBIOGRID;

interacts with

 CEBPBHPRD;

interacts with

 CENPEBIOGRID;

interacts with

 CEP55HPRD;

interacts with

 CFL1INTACT;

interacts with

 CHMP2AINTACT;

interacts with

 CHMP4BINTACT;

interacts with

 CIITABIOGRID;

interacts with

 CLIC1INTACT;

interacts with

 CLTCINTACT;

interacts with

 CMTM3HPRD;

interacts with

 CNN2INTACT;

interacts with

 COPAINTACT;

interacts with

 COPB1INTACT;

interacts with

 COPB2INTACT;

interacts with

 CPT1AINTACT;

interacts with

 CSDAHPRD;

interacts with

 CSDAMINT;

interacts with

 CSE1LINTACT;

interacts with

 CTNNB1INTACT;

interacts with

 CTNND1INTACT;

interacts with

 CUL3INTACT;

interacts with

 CYFIP1INTACT;

interacts with

 CYTH1INTACT;

interacts with

 CYTH2INTACT;

interacts with

 CYTH3INTACT;

interacts with

 DIAPH1INTACT;

interacts with

 Dlg4MINT;

interacts with

 DNM2INTACT;

interacts with

 DRG1INTACT;

interacts with

 DSTNINTACT;

interacts with

 DTYMKINTACT;

interacts with

 DUSP16BIOGRID;

interacts with

 DUSP16HPRD;

interacts with

 DUSP1BIOGRID;

interacts with

 DUSP1HPRD;

interacts with

 DUSP22BIOGRID;

interacts with

 DUSP23INTACT;

interacts with

 DUSP2HPRD;

interacts with

 DUSP3BIOGRID;

interacts with

 DUSP3HPRD;

interacts with

 DUSP4HPRD;

interacts with

 DUSP5HPRD;

interacts with

 DUSP6BIOGRID;

interacts with

 DUSP6HPRD;

interacts with

 DUSP7HPRD;

interacts with

 DYNC1H1INTACT;

interacts with

 DYNC1I2INTACT;

interacts with

 DYNC1LI2INTACT;

interacts with

 DYRK1BBIOGRID;

interacts with

 DYRK1BHPRD;

interacts with

 ECM29INTACT;

interacts with

 EGFRCELL_MAP;

interacts with

 EGFRHPRD;

interacts with

 EHD1INTACT;

interacts with

 EHD4INTACT;

interacts with

 EIF4EBP1HPRD;

interacts with

 ELK1BIOGRID;

interacts with

 ELK1HPRD;

interacts with

 EP300BIOGRID;

interacts with

 EPB41L2INTACT;

interacts with

 EPCAMINTACT;

interacts with

 EPORHPRD;

interacts with

 ERAP1INTACT;

interacts with

 ERFHPRD;

interacts with

 ESR1BIOGRID;

interacts with

 ESR1HPRD;

interacts with

 ESR2BIOGRID;

interacts with

 ESYT1INTACT;

interacts with

 ETHE1INTACT;

interacts with

 ETS1HPRD;

interacts with

 FANCIINTACT;

interacts with

 FAR2INTACT;

interacts with

 FASNINTACT;

interacts with

 FCGR2BHPRD;

interacts with

 FDFT1INTACT;

interacts with

 FFRINTACT;

interacts with

 FHL2BIOGRID;

interacts with

 FHL3HPRD;

interacts with

 FNTAINTACT;

interacts with

 FOSBIOGRID;

interacts with

 FRS2HPRD;

interacts with

 FRS3HPRD;

interacts with

 G3BP1INTACT;

interacts with

 G6PDINTACT;

interacts with

 GAB1HPRD;

interacts with

 GAB2HPRD;

interacts with

 GABRR1HPRD;

interacts with

 GAPDHINTACT;

interacts with

 GATA1HPRD;

interacts with

 GATA2HPRD;

interacts with

 GATA4BIOGRID;

interacts with

 GBASINTACT;

interacts with

 GCN1L1INTACT;

interacts with

 GJA1HPRD;

interacts with

 GMFBHPRD;

interacts with

 GNPATINTACT;

interacts with

 GORASP2HPRD;

interacts with

 GRB10HPRD;

interacts with

 HADHAINTACT;

interacts with

 HADHBINTACT;

interacts with

 HDAC4BIOGRID;

interacts with

 HDAC4HPRD;

interacts with

 HLA-AINTACT;

interacts with

 HLA-BINTACT;

interacts with

 HLA-HINTACT;

interacts with

 HMMRBIOGRID;

interacts with

 HNF4ABIOGRID;

interacts with

 HSD17B4INTACT;

interacts with

 HSDL2INTACT;

interacts with

 HSF4HPRD;

interacts with

 HSP90AA1HPRD;

interacts with

 IER3BIOGRID;

interacts with

 IER3HPRD;

interacts with

 IER3MINT;

interacts with

 IFNAR1HPRD;

interacts with

 INSRBIOGRID;

interacts with

 IQGAP1HPRD;

interacts with

 IQGAP1INTACT;

interacts with

 IRS1HPRD;

interacts with

 ITGA6INTACT;

interacts with

 ITGAVHPRD;

interacts with

 ITGB1INTACT;

interacts with

 ITGB4INTACT;

interacts with

 ITGB6HPRD;

interacts with

 JUNDBIOGRID;

interacts with

 JUNDHPRD;

interacts with

 JUNBIOGRID;

interacts with

 JUNCELL_MAP;

interacts with

 KHDRBS1HPRD;

interacts with

 KIAA1967INTACT;

interacts with

 KIF5BINTACT;

interacts with

 KLF11HPRD;

interacts with

 KPNB1INTACT;

interacts with

 KRASINTACT;

interacts with

 KRT8BIOGRID;

interacts with

 KRT8HPRD;

interacts with

 KSR1HPRD;

interacts with

 KSR2HPRD;

interacts with

 LAMTOR3BIOGRID;

interacts with

 LAMTOR3HPRD;

interacts with

 LBRINTACT;

interacts with

 LCKHPRD;

interacts with

 LCKMINT;

interacts with

 LDHAINTACT;

interacts with

 LGALS3INTACT;

interacts with

 LGALS4INTACT;

interacts with

 LIFRHPRD;

interacts with

 LIPEHPRD;

interacts with

 LLGL2INTACT;

interacts with

 LRPAP1HPRD;

interacts with

 LRPPRCINTACT;

interacts with

 LRRC59INTACT;

interacts with

 MAP2K1BIOGRID;

interacts with

 MAP2K1HPRD;

interacts with

 MAP2K1MINT;

interacts with

 MAP2K2BIOGRID;

interacts with

 MAP2K2HPRD;

interacts with

 MAP3K1BIOGRID;

interacts with

 MAP3K1HPRD;

interacts with

 MAPK14BIOGRID;

interacts with

 MAPK14CELL_MAP;

interacts with

 MAPK14HPRD;

interacts with

 MAPK3HPRD;

interacts with

 MAPK8HPRD;

interacts with

 MAPKAPK2BIOGRID;

interacts with

 MAPKAPK5HPRD;

interacts with

 MAPTHPRD;

interacts with

 MARCKSL1INTACT;

interacts with

 MBPHPRD;

interacts with

 MCL1HPRD;

interacts with

 METAP2HPRD;

interacts with

 MKNK1BIOGRID;

interacts with

 MKNK2BIOGRID;

interacts with

 MKNK2HPRD;

interacts with

 MTPNBIOGRID;

interacts with

 MTPNINTACT;

interacts with

 MX1INTACT;

interacts with

 MYCBIOGRID;

interacts with

 MYH14INTACT;

interacts with

 MYH9INTACT;

interacts with

 MYO18AINTACT;

interacts with

 MYO1EINTACT;

interacts with

 NAA15INTACT;

interacts with

 NACAINTACT;

interacts with

 NCOA1HPRD;

interacts with

 NCOA3HPRD;

interacts with

 NDE1HPRD;

interacts with

 NEFHHPRD;

interacts with

 NEFMHPRD;

interacts with

 NEK2BIOGRID;

interacts with

 NEK2HPRD;

interacts with

 NGFRHPRD;

interacts with

 NIPSNAP1INTACT;

interacts with

 NKX2-1HPRD;

interacts with

 NR3C1HPRD;

interacts with

 NR5A1HPRD;

interacts with

 NSDHLINTACT;

interacts with

 NSFINTACT;

interacts with

 NTPCRINTACT;

interacts with

 NUDT4INTACT;

interacts with

 PAK1HPRD;

interacts with

 PAK2HPRD;

interacts with

 PARFINTACT;

interacts with

 PDS5AINTACT;

interacts with

 PDZD8INTACT;

interacts with

 PEA15BIOGRID;

interacts with

 PEA15HPRD;

interacts with

 PEA15MINT;

interacts with

 PEBP1BIOGRID;

interacts with

 PEBP1CELL_MAP;

interacts with

 PEBP1HPRD;

interacts with

 PECAM1BIOGRID;

interacts with

 PFKLINTACT;

interacts with

 PFKPINTACT;

interacts with

 PGAM1INTACT;

interacts with

 PGRBIOGRID;

interacts with

 PHBINTACT;

interacts with

 PHGDHINTACT;

interacts with

 PHLDB1INTACT;

interacts with

 PIGSINTACT;

interacts with

 PITPNBINTACT;

interacts with

 PKN2INTACT;

interacts with

 PLATHPRD;

interacts with

 PLCB1HPRD;

interacts with

 PLEK2INTACT;

interacts with

 PLK3HPRD;

interacts with

 PLLPINTACT;

interacts with

 PLS1INTACT;

interacts with

 POTEEINTACT;

interacts with

 PPARAHPRD;

interacts with

 PPARGHPRD;

interacts with

 PPP1CAHPRD;

interacts with

 PPP1CAINTACT;

interacts with

 PPP1R9BHPRD;

interacts with

 PPP2CAHPRD;

interacts with

 PPP2R5CMINT;

interacts with

 PRKCDHPRD;

interacts with

 PRKCEBIOGRID;

interacts with

 PRKCEHPRD;

interacts with

 PRKCZHPRD;

interacts with

 PTGES2INTACT;

interacts with

 PTPN1HPRD;

interacts with

 PTPN5BIOGRID;

interacts with

 PTPN5HPRD;

interacts with

 PTPN7BIOGRID;

interacts with

 PTPN7HPRD;

interacts with

 PTPN9INTACT;

interacts with

 PTPRHHPRD;

interacts with

 PTPRRBIOGRID;

interacts with

 PTPRRHPRD;

interacts with

 PXNHPRD;

interacts with

 RAB11AINTACT;

interacts with

 RAB6AINTACT;

interacts with

 RAC2INTACT;

interacts with

 RAF1BIOGRID;

interacts with

 RAF1HPRD;

interacts with

 RALAINTACT;

interacts with

 RALBINTACT;

interacts with

 RANBP1INTACT;

interacts with

 RANINTACT;

interacts with

 RB1HPRD;

interacts with

 REPS1INTACT;

interacts with

 RGS19HPRD;

interacts with

 RHEBINTACT;

interacts with

 RPN1INTACT;

interacts with

 RPN2INTACT;

interacts with

 RPS6KA1BIOGRID;

interacts with

 RPS6KA1CELL_MAP;

interacts with

 RPS6KA1HPRD;

interacts with

 RPS6KA2BIOGRID;

interacts with

 Rps6ka3BIOGRID;

interacts with

 RPS6KA3BIOGRID;

interacts with

 Rps6ka3CELL_MAP;

interacts with

 RPS6KA3HPRD;

interacts with

 RPS6KA4HPRD;

interacts with

 Rps6kb1BIOGRID;

interacts with

 RPS6KB1HPRD;

interacts with

 RQCD1INTACT;

interacts with

 RRASINTACT;

interacts with

 RXRABIOGRID;

interacts with

 SAR1AINTACT;

interacts with

 SARNPINTACT;

interacts with

 SCCPDHINTACT;

interacts with

 SCNN1GHPRD;

interacts with

 SCP2INTACT;

interacts with

 SEC22BINTACT;

interacts with

 SEPT11INTACT;

interacts with

 SEPT2INTACT;

interacts with

 SEPT7INTACT;

interacts with

 SEPT9INTACT;

interacts with

 SFPQBIOGRID;

interacts with

 SFXN1INTACT;

interacts with

 SGPL1INTACT;

interacts with

 SHC1BIOGRID;

interacts with

 SHC1HPRD;

interacts with

 SLC25A1INTACT;

interacts with

 SLC25A24INTACT;

interacts with

 SLC25A3INTACT;

interacts with

 SLC25A5INTACT;

interacts with

 SLC9A1HPRD;

interacts with

 SMAD1BIOGRID;

interacts with

 SMAD1HPRD;

interacts with

 SMAD2HPRD;

interacts with

 SMAD4HPRD;

interacts with

 SNAPININTACT;

interacts with

 SNCABIOGRID;

interacts with

 SNCAHPRD;

interacts with

 SNCGBIOGRID;

interacts with

 SNX5INTACT;

interacts with

 SORBS3BIOGRID;

interacts with

 SORBS3HPRD;

interacts with

 SOS1HPRD;

interacts with

 SP1HPRD;

interacts with

 SPRY2BIOGRID;

interacts with

 SPTAN1INTACT;

interacts with

 SPTBN1INTACT;

interacts with

 SQRDLINTACT;

interacts with

 SRCHPRD;

interacts with

 SREBF1BIOGRID;

interacts with

 SREBF1HPRD;

interacts with

 SREBF2BIOGRID;

interacts with

 SREBF2HPRD;

interacts with

 SRP54INTACT;

interacts with

 SRP72INTACT;

interacts with

 SRP9INTACT;

interacts with

 SRPK1INTACT;

interacts with

 SSRP1INTACT;

interacts with

 STARD10INTACT;

interacts with

 STAT3HPRD;

interacts with

 STAT5ABIOGRID;

interacts with

 STAT5AHPRD;

interacts with

 STAT5BHPRD;

interacts with

 STXBP5INTACT;

interacts with

 TAGLN2INTACT;

interacts with

 TBC1D4INTACT;

interacts with

 TCF3HPRD;

interacts with

 TFCP2BIOGRID;

interacts with

 TFRCINTACT;

interacts with

 TGIF1HPRD;

interacts with

 THBIOGRID;

interacts with

 THHPRD;

interacts with

 TLN1INTACT;

interacts with

 TMEM109INTACT;

interacts with

 TMEM33INTACT;

interacts with

 TMOD2INTACT;

interacts with

 TMOD3INTACT;

interacts with

 TNFRSF1AHPRD;

interacts with

 TNFRSF25HPRD;

interacts with

 TNFSF11HPRD;

interacts with

 TNIP1BIOGRID;

interacts with

 TNIP1CELL_MAP;

interacts with

 TNKS2BIOGRID;

interacts with

 TOB1BIOGRID;

interacts with

 TOB1HPRD;

interacts with

 TOP2ABIOGRID;

interacts with

 TP53BIOGRID;

interacts with

 TPD52L2INTACT;

interacts with

 TPD52INTACT;

interacts with

 TPRBIOGRID;

interacts with

 TPRHPRD;

interacts with

 TRIM28INTACT;

interacts with

 TSC2BIOGRID;

interacts with

 TSC2HPRD;

interacts with

 TSPAN8INTACT;

interacts with

 TTC39BINTACT;

interacts with

 UBE2NINTACT;

interacts with

 UBR5BIOGRID;

interacts with

 UBR5HPRD;

interacts with

 UBTFHPRD;

interacts with

 UCK2INTACT;

interacts with

 VAV1BIOGRID;

interacts with

 VAV1HPRD;

interacts with

 VDRBIOGRID;

interacts with

 VSNL1INTACT;

interacts with

 VTA1INTACT;

interacts with

 XPO1INTACT;

interacts with

 XPO7INTACT;

interacts with

 YBX1HPRD;

interacts with

 YBX1MINT;

interacts with

 ZC3H15INTACT;

interacts with

 ZFP36HPRD;

Metabolic Interaction   [Top]

There is no record for MAPK1

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 AP2B1REACTOME;

reacts with

 AP2M1REACTOME;

reacts with

 AP2S1REACTOME;

reacts with

 CAPN2NCI_NATURE;

reacts with

 CNKSR1IMID;

reacts with

 L1CAMREACTOME;

reacts with

 LAMTOR3IMID;

reacts with

 MAP2K2REACTOME;

reacts with

 MAPK1IMID;

reacts with

 MAPK1NCI_NATURE;

reacts with

 MAPK1REACTOME;

reacts with

 MAPK3NCI_NATURE;

reacts with

 SH3GL2REACTOME;

state change

 DUSP1IMID;

state change

 MAP2K1CELL_MAP;

state change

 MAP2K1NCI_NATURE;

state change

 MAP2K2NCI_NATURE;

state change

 MAP2K2REACTOME;

state change

 MAP3K2IMID;

state change

 MAP4K1IMID;

state change

 MAPK1REACTOME;

state change

 PTPN5IMID;

state change

 RAF1REACTOME;

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