| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3630 |
Name | INS |
Synonymous | insulin;INS;insulin |
Definition | preproinsulin|proinsulin |
Position | 11p15.5 |
Gene type | protein-coding |
Title | Abstract |
| pancreatic cancer | OBJECTIVE: To explore the correlation between the expressions of hypoxia inducible factor-1alpha (HIF-1alpha) and insulin in pancreatic cancer. METHODS: HIF-1alpha and insulin expression was detected by immunohistochemistry in the center and the edge of pancreatic adenocarcinoma specimens of 65 cases. Western blot was used to detect HIF-1alpha expression and insulin level in the center and the edge of pancreatic adenocarcinoma specimens of 28 cases. The relationship between HIF-1alpha expression and insulin level in the pancreatic cancer was analyzed. RESULTS: The results of immunohistochemistry and Western blot showed that HIF-1alpha protein expression was high in both the center and the edge of pancreatic cancers (P > 0.05), and insulin level was significantly higher at the edge of specimen than that in the center (P < 0.05). HIF-1alpha protein and insulin levels were positively correlated at the edge of cancer tissue (r = 0.374, P < 0.05), but no significant correlation between them in the center of cancerous tissue (r = -0.145, P > 0.05). CONCLUSION: Insulin may promote the local invasion and metastasis of pancreatic cancer by up-regulating HIF-1alpha. |