Entrez Gene

Cancer metastasis gene database Home

General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information
Gene ID	7465
Name	WEE1
Synonymous	WEE1 G2 checkpoint kinase;WEE1;WEE1 G2 checkpoint kinase
Definition	WEE1 homolog\|WEE1+ homolog\|wee1-like protein kinase\|wee1A kinase
Position	11p15.4
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
Wee1(h) + 14-3-3beta(h) <==> Wee1(h):14-3-3beta(h) (binding)
beta-TrCP1(h) + Wee1(h) <==> beta-TrCP1(h):Wee1(h) (binding)
HOS(h) + Wee1(h) <==> HOS(h):Wee1(h) (binding)
Skp2(h) + Wee1(h) <==> Skp2(h):Wee1(h) (binding)
Wee1(h) + ATP --plk1(m)--> Wee1(h){pS53} + ADP (phosphorylation)
Wee1(h) + ATP --cyclinB1(v.s.):Cdk1(v.s.)--> Wee1(h){pS123} + ADP (phosphorylation)
14-3-3sigma(m.s.) + Wee1(h) <==> 14-3-3sigma(m.s.):Wee1(h) (binding)
WEE1(h) --> Wee1(h) (expression).
Cdk2(h) + ATP --Wee1(h)--> Cdk2(h){pY15} + ADP (phosphorylation)
cyclinB1(h):Cdk1(h) + ATP --Wee1(h)--> cyclinB1(h):Cdk1(h){pY15} + ADP (phosphorylation)
Cdk1(h) + ATP --Wee1(h)--> Cdk1(h){pY15} + ADP (phosphorylation)
cyclinA(h):Cdk2(h) + ATP --Wee1(h)--> cyclinA(h):Cdk2(h){p} + ADP (phosphorylation)
cyclinE(h):Cdk2(h) + ATP --Wee1(h)--> cyclinE(h):Cdk2(h){p} + ADP (phosphorylation)
WEE1(h) --> Wee1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
123	Phosphoserine (by CDC2) (Potential).		Swiss-Prot 53.0
127	Phosphoserine.		Swiss-Prot 53.0
139	Phosphoserine.		Swiss-Prot 53.0
165	Phosphoserine.		Swiss-Prot 53.0
173	Phosphothreonine.		Swiss-Prot 53.0
642	Phosphoserine; by BRSK1; in vitro.		Swiss-Prot 53.0
53	Phosphoserine (CDK1;PLK2)	15070733;16085715	Phospho.ELM 6.0
139	Phosphoserine	15302935;17081983	Phospho.ELM 6.0
123	Phosphoserine (CDK1;PLK2)	15070733;16085715	Phospho.ELM 6.0
121	Phosphoserine	16085715	Phospho.ELM 6.0
127	Phosphoserine	17081983	Phospho.ELM 6.0
165	Phosphoserine	17081983	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr11	Promoter: 9549416 - 9551416	Agilent_014791
chr11	Promoter: 9549416 - 9551416	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 9549416 - 9551416	GSE27584
chr11	Promoter: 9549416 - 9551416	Agilent_014791_44K