Entrez Gene

Basic Information
Gene ID	7465
Name	WEE1
Synonymous	WEE1 G2 checkpoint kinase;WEE1;WEE1 G2 checkpoint kinase
Definition	WEE1 homolog\|WEE1+ homolog\|wee1-like protein kinase\|wee1A kinase
Position	11p15.4
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1428A>G; p.E476E; 11:9585485-9585485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1428A>G; p.E476E; 11:9585485-9585485	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1428A>G; p.E476E; 11:9585485-9585485	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.965G>A; p.G322E; 11:9576605-9576605	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.965G>A; p.G322E; 11:9576605-9576605	breast	carcinoma	Substitution - Missense
c.1434C>T; p.G478G; 11:9585491-9585491	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1597C>T; p.R533W; 11:9586575-9586575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.638T>G; p.L213R; 11:9575949-9575949	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1082G>T; p.R361L; 11:9577204-9577204	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1082G>T; p.R361L; 11:9577204-9577204	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.732G>T; p.L244F; 11:9576043-9576043	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.735T>G; p.L245L; 11:9576046-9576046	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.735T>G; p.L245L; 11:9576046-9576046	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1665G>A; p.E555E; 11:9586734-9586734	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1539T>C; p.A513A; 11:9586517-9586517	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.288C>T; p.P96P; 11:9574221-9574221	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1740A>T; p.L580F; 11:9586809-9586809	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1345G>A; p.E449K; 11:9585314-9585314	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1125G>C; p.Q375H; 11:9577247-9577247	breast	carcinoma	Substitution - Missense
c.661G>A; p.G221R; 11:9575972-9575972	liver	carcinoma	Substitution - Missense
c.1085A>G; p.Y362C; 11:9577207-9577207	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1094C>T; p.A365V; 11:9577216-9577216	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1256C>G; p.S419*; 11:9581646-9581646	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Nonsense
c.1060G>T; p.G354*; 11:9577182-9577182	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.115_117delGAG; p.E39delE; 11:9574048-9574050	prostate	carcinoma	Deletion - In frame
c.1834G>A; p.A612T; 11:9588495-9588495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.876G>A; p.K292K; 11:9576516-9576516	skin	malignant_melanoma	Substitution - coding silent
c.876G>A; p.K292K; 11:9576516-9576516	skin	malignant_melanoma	Substitution - coding silent
c.1828G>A; p.E610K; 11:9588489-9588489	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.117G>A; p.E39E; 11:9574050-9574050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1828G>A; p.E610K; 11:9588489-9588489	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.764A>G; p.K255R; 11:9576075-9576075	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.764A>G; p.K255R; 11:9576075-9576075	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.874A>G; p.K292E; 11:9576514-9576514	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.764A>G; p.K255R; 11:9576075-9576075	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.764A>G; p.K255R; 11:9576075-9576075	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1178G>C; p.R393T; 11:9581568-9581568	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1697A>G; p.H566R; 11:9586766-9586766	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.252C>G; p.G84G; 11:9574185-9574185	thyroid	other; neoplasm	Substitution - coding silent
c.1752G>T; p.L584F; 11:9586821-9586821	breast	carcinoma	Substitution - Missense
c.1102G>A; p.E368K; 11:9577224-9577224	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1762A>C; p.K588Q; 11:9586831-9586831	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1678G>T; p.A560S; 11:9586747-9586747	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1046C>T; p.A349V; 11:9577168-9577168	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1069T>G; p.S357A; 11:9577191-9577191	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1938C>T; p.Y646Y; 11:9588599-9588599	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1306C>T; p.R436*; 11:9585275-9585275	skin	malignant_melanoma	Substitution - Nonsense
c.923G>C; p.G308A; 11:9576563-9576563	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1081C>T; p.R361*; 11:9577203-9577203	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1081C>T; p.R361*; 11:9577203-9577203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1083A>G; p.R361R; 11:9577205-9577205	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.166C>G; p.Q56E; 11:9574099-9574099	urinary_tract; bladder	carcinoma	Substitution - Missense
c.763A>G; p.K255E; 11:9576074-9576074	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.763A>G; p.K255E; 11:9576074-9576074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.765G>A; p.K255K; 11:9576076-9576076	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1081C>A; p.R361R; 11:9577203-9577203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.662G>T; p.G221V; 11:9575973-9575973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.928_929insT; p.G311fs*5; 11:9576568-9576569	stomach	adenocarcinoma	Insertion - Frameshift
c.1027G>A; p.A343T; 11:9577149-9577149	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.497C>T; p.P166L; 11:9574430-9574430	liver	carcinoma	Substitution - Missense
c.1093G>A; p.A365T; 11:9577215-9577215	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1522G>T; p.V508L; 11:9586500-9586500	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1713C>T; p.S571S; 11:9586782-9586782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1138A>G; p.N380D; 11:9577260-9577260	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1638A>G; p.L546L; 11:9586616-9586616	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1604C>A; p.P535Q; 11:9586582-9586582	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1742G>A; p.R581Q; 11:9586811-9586811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1252C>T; p.H418Y; 11:9581642-9581642	skin	malignant_melanoma	Substitution - Missense
c.1742G>C; p.R581P; 11:9586811-9586811	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.577-1G>T; p.?; 11:9575887-9575887	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.1446T>G; p.F482L; 11:9585503-9585503	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1875G>C; p.Q625H; 11:9588536-9588536	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1289-6T>C; p.?; 11:9585252-9585252	liver	carcinoma	Unknown
c.1289-6T>C; p.?; 11:9585252-9585252	liver	carcinoma	Unknown
c.1463T>A; p.L488*; 11:9585520-9585520	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1235G>A; p.R412Q; 11:9581625-9581625	prostate	carcinoma	Substitution - Missense
c.1551G>A; p.P517P; 11:9586529-9586529	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1133A>G; p.Y378C; 11:9577255-9577255	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1275G>T; p.M425I; 11:9581665-9581665	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.577-1G>A; p.?; 11:9575887-9575887	urinary_tract; bladder	carcinoma	Unknown
c.1589G>C; p.R530T; 11:9586567-9586567	oesophagus	carcinoma	Substitution - Missense
c.1125G>A; p.Q375Q; 11:9577247-9577247	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.616G>T; p.V206F; 11:9575927-9575927	skin	malignant_melanoma	Substitution - Missense
c.1759G>A; p.E587K; 11:9586828-9586828	pancreas	carcinoma	Substitution - Missense
c.1759G>A; p.E587K; 11:9586828-9586828	pancreas	carcinoma	Substitution - Missense
c.1759G>A; p.E587K; 11:9586828-9586828	pancreas	carcinoma	Substitution - Missense
c.1834G>T; p.A612S; 11:9588495-9588495	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.812A>G; p.D271G; 11:9576259-9576259	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1729G>A; p.A577T; 11:9586798-9586798	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1333G>T; p.E445*; 11:9585302-9585302	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1333G>T; p.E445*; 11:9585302-9585302	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.1550C>T; p.P517L; 11:9586528-9586528	skin	malignant_melanoma	Substitution - Missense
c.1550C>T; p.P517L; 11:9586528-9586528	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]