| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7410 |
Name | VAV2 |
Synonymous | vav 2 guanine nucleotide exchange factor;VAV2;vav 2 guanine nucleotide exchange factor |
Definition | guanine nucleotide exchange factor VAV2|vav 2 oncogene |
Position | 9q34.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | SPIN90(h) + Vav-2(h) <==> SPIN90(h):Vav-2(h) (binding) | Vav-2(h) + NTP --Src(v.s.)--> Vav-2(h){pY} + NDP (phosphorylation) | SPIN90(v.s.) + Vav-2(h) <==> SPIN90(v.s.):Vav-2(h) (binding) | Nek3(h) + Vav-2(h) <==> Nek3(h):Vav-2(h) (binding) | Vav-2(h) + ATP --> Vav-2(h){pS}{pY} + ADP (phosphorylation) | Vav-2(h) + ATP --> Vav-2(h){pY} + ADP (phosphorylation) | Vav-2(h) + EGFR(h){pY} <==> Vav-2(h):EGFR(h){pY} (binding) | Vav-2(h) + CD44(h) <==> Vav-2(h):CD44(h) (binding) | Vav-2(h) + Grb-2(h) + CD44(h) + ErbB2(h) <==> Vav-2(h):Grb-2(h):CD44(h):ErbB2(h) (binding) | Grb-2(m.s.) + Vav-2(h) + CD44(h) + ErbB2(h) <==> Grb-2(m.s.):Vav-2(h):CD44(h):ErbB2(h) (binding) | VAV2(h) --> Vav-2(h) (expression). | Rac1(m.s.):GDP + GTP --Vav-2(h)--> Rac1(m.s.):GTP + GDP (exchange) | Vav-2(h) + CD44(h) <==> Vav-2(h):CD44(h) (binding) | ErbB1-p170(h){pY1016} + Vav-2(h) <==> ErbB1-p170(h){pY1016}:Vav-2(h) (binding) | ErbB2(h){pY1139}{pY1196}{pY1221} + Vav-2(h) <==> ErbB2(h){pY1139}{pY1196}{pY1221}:Vav-2(h) (binding) | ErbB3-isoform1(h){pY1276} + Vav-2(h) <==> ErbB3-isoform1(h){pY1276}:Vav-2(h) (binding) | ErbB4(h){pY1162}{pY1258}{pY1284} + Vav-2(h) <==> ErbB4(h){pY1162}{pY1258}{pY1284}:Vav-2(h) (binding) | VAV2(h) --> Vav-2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 142 | Phosphotyrosine (by EGFR). | Swiss-Prot 53.0 | 159 | Phosphotyrosine (by EGFR). | Swiss-Prot 53.0 | 172 | Phosphotyrosine (by EGFR). | Swiss-Prot 53.0 | 159 | Phosphotyrosine (Lck;EGFR) | 12454019 | Phospho.ELM 6.0 | 142 | Phosphotyrosine (Lck;EGFR) | 12454019 | Phospho.ELM 6.0 | 172 | Phosphotyrosine (Lck;EGFR) | 12454019 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr9 |
Promoter: 135846726 - 135848726 | Agilent_014791 |
chr9 |
Promoter: 135846726 - 135848726 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 135846726 - 135848726 | GSE27584 |
chr9 |
Promoter: 135846726 - 135848726 | Agilent_014791_44K |