| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7410 |
Name | VAV2 |
Synonym | VAV-2;vav 2 guanine nucleotide exchange factor;VAV2;vav 2 guanine nucleotide exchange factor |
Definition | guanine nucleotide exchange factor VAV2|vav 2 oncogene |
Position | 9q34.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Regulation of RAC1 activity;PID Curated;200165 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Regulation of CDC42 activity;PID Curated;200059 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | phosphoinositides and their downstream targets;PID BioCarta;100059 |
Pathway | Signal transduction by L1;PID Reactome;500100 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Regulation of RhoA activity;PID Curated;200050 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Disease | Multiple sclerosis;NHGRI |
External Links | |
Links to Entrez Gene | 7410 |
Links to all GeneRIF Items | 7410 |
Links to iHOP | 7410 |
Sequence Information | |
Nucleotide Sequence | >7410 : length: 4925 CCGGCCCTGAGCCCCGCGCGCGCGCGGGCGGGATGCCCCGCGGCCGCTGCACTTTGGCTC GAGCACTGCCCTGAGCCGGTCGGGCCCGCGGGCGCCATGGAGCAGTGGCGGCAGTGCGGC CGCTGGCTCATCGATTGCAAGGTCCTGCCGCCCAACCACCGGGTGGTGTGGCCCTCGGCC GTGGTCTTCGACCTGGCGCAGGCGCTGCGCGACGGGGTCCTTCTGTGCCAGCTGCTGCAC AACCTCTCCCCCGGCTCCATCGACCTCAAGGACATCAACTTCCGGCCGCAGATGTCCCAG TTTCTGTGTTTGAAGAACATACGCACCTTCCTGAAAGTCTGCCACGATAAATTTGGATTA AGGAACAGCGAGCTGTTTGACCCCTTTGACCTCTTCGATGTGCGAGACTTTGGAAAGGTC ATCTCCGCGGTGTCGAGGCTCTCCCTGCACAGCATCGCGCAGAACAAAGGGATCAGGCCT TTTCCCTCAGAGGAGACCACAGAGAATGACGATGACGTCTACCGCAGCCTGGAGGAGCTG GCCGACGAGCATGACCTGGGGGAGGACATCTACGACTGCGTCCCGTGTGAGGATGGAGGG GACGACATCTACGAGGACATCATCAAGGTGGAGGTGCAGCAGCCCATGAAAATGGGCATG ACTGAAGATGACAAGAGGAACTGCTGCCTGCTGGAGATCCAGGAGACCGAGGCCAAGTAC TACCGCACCCTGGAGGACATTGAGAAGAACTACATGAGCCCCCTGCGGCTGGTGCTGAGC CCGGCGGACATGGCAGCTGTCTTCATTAACCTGGAGGACCTGATCAAGGTGCATCACAGC TTCCTGAGGGCCATCGACGTGTCCGTGATGGTGGGGGGCAGCACGCTGGCCAAGGTCTTC CTCGATTTCAAGGAAAGGCTTCTGATCTACGGGGAGTACTGCAGCCACATGGAGCACGCC CAGAACACACTGAACCAGCTCCTGGCCAGCCGGGAGGACTTCAGGCAGAAAGTCGAGGAG TGCACACTGAAGGTCCAGGATGGAAAATTTAAGCTGCAAGACCTGCTGGTGGTCCCCATG CAGAGGGTGCTCAAATACCACCTGCTCTTGAAGGAGCTTCTGAGCCATTCTGCGGAACGG CCTGAGAGGCAGCAGCTCAAAGAAGCACTGGAAGCCATGCAGGACTTGGCGATGTACATC AATGAAGTTAAACGGGACAAGGAGACCTTGAGGAAAATCAGCGAATTTCAGAGTTCTATA GAAAATTTGCAAGTGAAACTGGAGGAATTTGGAAGACCAAAGATTGACGGGGAACTGAAA GTCCGGTCCATAGTCAACCACACCAAGCAGGACAGGTACTTGTTCCTGTTTGACAAGGTG GTCATCGTCTGCAAGCGGAAGGGCTACAGCTACGAGCTCAAGGAGATCATCGAGCTGCTG TTCCACAAGATGACCGACGACCCCATGAACAACAAGGACGTCAAGAAGCAAGCAGGCTTT CCTCTCCCGTCCCACCCTGCGGTGCTTGGAGGAGGGCTGTGGTGGTCCTACGGCTTCTAC CTAATTCACCTTCAAGGAAAGCAGGGCTTCCAGTTTTTCTGCAAAACAGAAGATATGAAG AGGAAGTGGATGGAGCAGTTTGAGATGGCCATGTCAAACATCAAGCCAGACAAAGCCAAT GCCAACCACCACAGTTTCCAGATGTACACGTTTGACAAGACCACCAACTGCAAAGCCTGC AAAATGTTCCTCAGGGGCACCTTCTACCAGGGATACATGTGTACCAAGTGTGGCGTCGGG GCACACAAGGAGTGCCTGGAAGTGATACCTCCCTGCAAGTTCACTTCTCCTGCAGATCTG GACGCCTCCGGAGCGGGACCAGGTCCCAAGATGGTGGCCATGCAGAATTACCATGGCAAC CCAGCCCCTCCCGGGAAGCCTGTGCTGACCTTCCAGACGGGCGACGTGCTTGAGCTGCTG AGGGGCGACCCTGAGTCTCCGTGGTGGGAGGGTCGTCTGGTACAAACCAGGAAGTCAGGG TATTTCCCCAGCTCATCTGTGAAGCCCTGCCCTGTGGATGGAAGGCCGCCCATCAGCCGG CCGCCATCCCGGGAGATCGACTACACTGCATACCCCTGGTTTGCAGGTAACATGGAGAGG CAGCAGACGGACAACCTGCTCAAGTCCCACGCCAGCGGGACCTACCTGATCAGGGAGCGG CCTGCCGAGGCTGAGCGCTTTGCAATAAGCATCAAGTTCAATGATGAGGTGAAGCACATC AAGGTGGTGGAGAAGGACAACTGGATCCACATCACAGAGGCCAAGAAATTCGACAGCCTC CTGGAGTTGGTGGAGTACTACCAGTGCCACTCACTGAAGGAGAGCTTCAAGCAGCTGGAC ACCACACTCAAGTACCCCTACAAGTCCCGGGAACGTTCGGCCTCCAGGGCCTCCAGCCGG TCCCCAGCTTCCTGTGCTTCCTACAACTTTTCTTTTCTCAGTCCTCAGGGCCTCAGCTTT GCTTCTCAGGGCCCCTCCGCTCCCTTCTGGTCAGTGTTCACGCCCCGCGTCATCGGCACA GCTGTGGCCAGGTATAACTTTGCCGCCCGAGATATGAGGGAGCTTTCGCTGCGGGAGGGT GACGTGGTGAGGATCTACAGCCGCATCGGCGGAGACCAGGGCTGGTGGAAGGGCGAGACC AACGGACGGATTGGCTGGTTTCCTTCAACGTACGTAGAAGAGGAGGGCATCCAGTGACGG CAGGAACGTGGACAAGACTCGCAGATTTTCTTGGGAGAGTCACTCCAGCCCTGAAGTCTG TCTCTAGCTCCTCTGTGACTCAGAGGGGAAATACCAACCTCCCAGTCTTCCACTGCCCAC AGGGATAGGGAGGGTGTTGAGAATCCTAAACTCGAACCGTTTCACTGTCAGCCTGCCCTC GGCGACCCATCACTGGGTATGCTATTGTACATAGAGGAAACCTGGGCTAGCCCCACCCAG AGCGCAGAGGAGGGGGCACCGACAGCGCTGCGAGCCAGGCTCTGGGTAGTGGCTGAGGCC AGAGGCCCATCGCCTGCCCCTGTCCAACTGAGATGGCCTTCAGGAGCCTAGGTTTGAACA GCAGATGCTGTCCCAGGAAGGGCTAGGGACATCGGAGGGGACCTGCCCCCACACCCTCTG CTCAGCCCCTGGACTCAGCCTTGCCTGTCTTTTCCTGCTGCTCCCAGGGGGAGGTGTCAG ACCTCGGGAGGCAGACGGGACCAGAGCCAGGCTGTTCACTGTGGGCCCACTTGCCCCACT GTGCTAGGGCGCGGGAGGAGAGAGCACTGTGGTCGCCCTCTGCAGCCACTCTGGCTCCCA AGACTTCCCTGACTCCCCCACTCCCCTCCTTGCCAGGGGCACACCCGGACCCCACACGGC AGGCCCCTCTCTTGGGAGGGGCCTTTGGAATGATGAAATTCCAACCCTGCTGCCCGGTCA GCGGTACCGTTTCCTGCCCTCTCTCTGAGAGGCCCTTTCTGGAGTCCTGGGAAGGTGTCT GCCTGGCCGCGCTGCCAGATCAGTACATCTTTTGTAAAAACCCTGAAATGGGCAGGGAAG AAAACAGGGATTTCCCCTCTCTAGATCCCTGCCAGGTCCCTCTCCAGGAGGCCCCTCTGC TCTCCTGAAGGGTGGTCCCTGAGGGTCTGCCCAGCCTTGGCACGAGAGGTTGGTTCCAGC CCCTGGCAGGGCTTCCTTCCAAGGGCCCCTGCAGCCTACAAACTGGGCCTCGGGCGACTC AAAATAAGTGCTCTTGGGGGTGGCTCTACCCCATTACCTCCCCCAGCCACAACTCCTGGC CTTCGACTTCTGGCTGGGTTAGCCAGACCCTGGTTTCTCTACCCTGATGTTGCATGAGAC CTGGTAACAGTGTCTCCCTCCCAGCTCCTTGCCAAAGCCTCTGTTGAGACCTGGGCTTCT TGTAGCCCCTTCTCCCTCTGGCCAGCTGCACAGCCTGTGGGAGGTGCCCGGCCCAGGCTG GGTGTGGGGGAAGCTGGTCCCTGCTGTGGGTGGCGCTGGGGACCTAGGGGCTCCTTCTGA GGTTGGCCTTGTGGCCTCTGGGCTGTATGCCTCTGGGGTGTAGGGAAGAGGCGGGAGGAG TCATGGGGATGGGGAGCGGCAGGGGGAGAGAGGGGCCCTCGACAAAGGCTTGGGAAATGA GGGGAGGTGGAGGCAGGGCAGGGGAAGCGAAGAGTCAGCCTTGGAGAGAGCACCCTGGGG CCTCCGTGTCGGGGTACACCCAGCACTTTGCGACCTGCGGCCCAGCAGGCGCGGAGGATG GCGGGGAGGAAGCCAGCAGCCCCTGTGTTTACTGTCGTCAGAAAGGTCTTGTGTTTTGGT TTTGGGGTTTTTGTTTTGTTTGTGTTTTGTTTGGCTTGTTTGTTTTTTAAGGGGAAAAAA GTTTGTAATTATTTCATCCAAATCTCCCGTTATATATCTGTGAATAATAAGAGATTTTAT AATAGCAAGAAAATGATGTATATTTTAGTTTGTTGACAAATAAGTCATCATGATCACGAA GGACACTGAGAAAAAATAATTTAGAACCCTGGTTTTTGTGAATTTTTTTGTTTTGTGTTT CTTTGTTTTGAGATTTGTGTTTGGTTTGGTTTTTGCACTGCACTAAGGCAGGAGGGTTGG AGGGCTGGGTGCAGCCTGGGAGTCCGATGGTTTTCAGCAGGAGACGGGGTGTCCCCTGCA GGGGGCTAAACTGCAGGGGCCTGAGATTAGCTGTGAACATGTGGGAGCCCGATGCATGTG GGTCAGGGATCTGGGGGCCCCCCCAGCTGGCGGGAACCCCAAATGGACACAAACTGTACA TTTGCCAATGGGTTTTTTTCAGACCATGGTTTTTACTTGCAAATAAACCTGAGTTCTTTT CTGCA |
Protein Sequence | >7410 : length: 886 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKQAGFPLPSHPAVLGGG LWWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFD KTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMV AMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPV DGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIK FNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRER SASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDM RELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ |