| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7189 |
Name | TRAF6 |
Synonymous | TNF receptor-associated factor 6, E3 ubiquitin protein ligase;TRAF6;TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer |
Position | 11p12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TRAF6(h) + T6BP(h) <==> TRAF6(h):T6BP(h) (binding) | TRAF6(h) + TAB1(h) + TAK1(h) <==> TRAF6(h):TAB1(h):TAK1(h) (binding) | TRAF6(h) + TAB2(h) <==> TRAF6(h):TAB2(h) (binding) | TRAF6(h) + TAB2(h) + TAK1(h) <==> TRAF6(h):TAB2(h):TAK1(h) (binding) | SITPEC(m) + TRAF6(h) <==> SITPEC(m):TRAF6(h) (binding) | TRAF6(h) --IRAK1(h){p}--> TRAF6(h) (translocation) | IRAK1(h) + TRAF6(h) <==> IRAK1(h):TRAF6(h) (binding) | IRAK1(h){p} + TAB2(h) + TRAF6(h) <==> IRAK1(h){p}:TRAF6(h):TAB2(h) (binding) | IRAK-2(h) + TRAF6(h) <==> IRAK-2(h):TRAF6(h) (binding) | XEDAR-L(h) + TRAF6(h) <==> XEDAR-L(h):TRAF6(h) (binding) | XEDAR(h) + TRAF6(h) <==> XEDAR(h):TRAF6(h) (binding) | RANK(h) + TRAF6(h) <==> RANK(h):TRAF6(h) (binding) | RANK(h) + TRAF6(h) + TAB2(h) <==> RANK(h):TRAF6(h):TAB2(h) (binding) | TRAF6(h) + TAK1(h) <==> TRAF6(h):TAK1(h) (binding) | cd40(h) + cIAP-1(h) + TRAF2(h) + TRAF3(h) + TRAF5(h) + TRAF6(h) <==> cd40(h):cd40(h):cd40(h):TRAF2(h):TRAF3(h):TRAF5(h):TRAF6(h):cIAP-1(h) (binding) | IRAK-4(h) + TRAF6(h) <==> IRAK-4(h):TRAF6(h) (binding) | TRIF(h) + TRAF6(h) <==> TRIF(h):TRAF6(h) (binding) | TRAM(h) + TRAF6(h) <==> TRAM(h):TRAF6(h) (binding) | TRAF6(h) + TAB2(h) + TAK1(h) + PKR(h) <==> TRAF6(h):TAB2(h):TAK1(h):PKR(h) (binding) | TLR3(h) + TRAF6(h) + TAB2(h) + TAK1(h) <==> TLR3(h):TRAF6(h):TAB2(h):TAK1(h) (binding) | IL-1beta(h) + IL-1RI(h) + MyD88(h) + IRAK-4(h) + IRAK1(h) + TRAF6(h) <==> IL-1beta(h):IL-1RI(h):MyD88(h):IRAK-4(h):IRAK1(h):TRAF6(h) (binding) | TRAF6(h) + IRAK1(h) + IRAK-4(h) + Pellino1(h) <==> TRAF6(h):IRAK1(h):IRAK-4(h):Pellino1(h) (binding) | TRAF6(h) + Pellino2(h) <==> TRAF6(h):Pellino2(h) (binding) | TRAF6(h) + Pellino1(h) <==> TRAF6(h):Pellino1(h) (binding) | TRAF6(h) + TAB3(h) <==> TRAF6(h):TAB3(h) (binding) | TRAF6(h) + TAB2(h):TAB3(h) <==> TRAF6(h):TAB2(h):TAB3(h) (binding) | TRAF6(h) + TAB3(h) + TAK1(h) <==> TRAF6(h):TAB3(h):TAK1(h) (binding) | TRAF6(h) + PKCzeta(h) + Ajuba(h) + p62(h) <==> TRAF6(h):PKCzeta(h):Ajuba(h):p62(h) (binding) | Caspase-8(h) + TRAF6(h) <==> Caspase-8(h):TRAF6(h) (binding) | IKK-beta(h) + TRAF6(h) <==> IKK-beta(h):TRAF6(h) (binding) | bcl10(h) + TRAF6(h) <==> bcl10(h):TRAF6(h) (binding) | TRAF6(h) + IRAK1c(h) <==> TRAF6(h):IRAK1c(h) (binding) | TRAF6(h) + IRAK1(m.s.) <==> TRAF6(h):IRAK1(m.s.) (binding) | TAK1(h) + TRAF6(h) + IRAK1(h) + Pellino3-isoform1(h) <==> TAK1(h):TRAF6(h):IRAK1(h):Pellino3-isoform1(h) (binding) | NIK(h) + TRAF6(h) + Pellino3-isoform1(h) <==> NIK(h):TRAF6(h):Pellino3-isoform1(h) (binding) | TRAF6(h) + TACI-isoform1(h) <==> TRAF6(h):TACI-isoform1(h) (binding) | TLR3(h) + TRAF6(h) <==> TLR3(h):TRAF6(h) (binding) | IL-1RI(h) + TRAF6(h) + IRAK1(h) <==> IL-1RI(h):TRAF6(h):IRAK1(h) (binding) | TAB2(h) + TRAF6(h) <==> TAB2(h):TRAF6(h) (binding) | TAB2(h) + TAK1(h) + TRAF6(h) + IRAK1(h) <==> TAB2(h):TAK1(h):TRAF6(h):IRAK1(h) (binding) | TRAF6(h) + ubiquitin(h) --> TRAF6(h){ub} (ubiquitination) | TRAF6(h) + n ubiquitin(h) --> TRAF6(h){ub(n)} (ubiquitination) | TRAF6(h) + SIGIRR(h) <==> TRAF6(h):SIGIRR(h) (binding) | TRAF6(h) + IKK-alpha(h) <==> TRAF6(h):IKK-alpha(h) (binding) | Caspase-4(h) + TRAF6(h) <==> Caspase-4(h):TRAF6(h) (binding) | Syntenin(h) + TRAF6(h) <==> Syntenin(h):TRAF6(h) (binding) | trkA(m.s.) + TRAF6(h) + p62(h) <==> trkA(m.s.):TRAF6(h):p62(h) (binding) | trkB-GP145(r) + TRAF6(h) + p62(h) <==> trkB-GP145(r):TRAF6(h):p62(h) (binding) | beta-arrestin1(h) + TRAF6(h) <==> beta-arrestin1(h):TRAF6(h) (binding) | beta-arrestin2(h) + TRAF6(h) <==> beta-arrestin2(h):TRAF6(h) (binding) | TRAF6(h) + n ubiquitin(h) --> TRAF6(h){ub}n (ubiquitination; automodification) | TRAF6(h) + MAVS(h) <==> TRAF6(h):MAVS(h) (binding) | TRAF6(h) + EPIPL(h) <==> TRAF6(h):EPIPL(h) (binding) | TRAF6(h) + phosphoribosylformylglycinamidine synthase(h) <==> TRAF6(h):phosphoribosylformylglycinamidine synthase(h) (binding) | TRAF6(h) + C-1-tetrahydrofolate synthase, cytoplasmic(h) <==> TRAF6(h):C-1-tetrahydrofolate synthase, cytoplasmic(h) (binding) | TRAF6(h) + NASP(h) <==> TRAF6(h):NASP(h) (binding) | TRAF6(h) + ValRS(h) <==> TRAF6(h):ValRS(h) (binding) | TRAF6(h) + vcp(h) <==> TRAF6(h):vcp(h) (binding) | TRAF6(h) + ILRS(h) <==> TRAF6(h):ILRS(h) (binding) | TRAF6(h) + GANAB(h) <==> TRAF6(h):GANAB(h) (binding) | TRAF6(h) + DDX3(h) <==> TRAF6(h):DDX3(h) (binding) | TRAF6(h) + eif4e2(h) <==> TRAF6(h):eif4e2(h) (binding) | TRAF6(h) + ThrRS(h) <==> TRAF6(h):ThrRS(h) (binding) | TRAF6(h) + multifunctional protein ADE2(h) <==> TRAF6(h):multifunctional protein ADE2(h) (binding) | TRAF6(h) + ASXH2(h) <==> TRAF6(h):ASXH2(h) (binding) | TRAF6(h) + tjp2(h) <==> TRAF6(h):tjp2(h) (binding) | TRAF6(h) + vdac1(h) <==> TRAF6(h):vdac1(h) (binding) | TRAF6(h) + CTP synthase 1(h) <==> TRAF6(h):CTP synthase 1(h) (binding) | TRAF6(h) + mcm7(h) <==> TRAF6(h):mcm7(h) (binding) | TRAF2(h) + TRAF6(h) <==> TRAF2(h):TRAF6(h) (binding) | TRAF6(h) --> MMP-13(h) (increase of abundance) | TRAF6(h) --> c-Jun(h){p} (increase of phosphorylation) | TRAF6(h) --> JNK(h){p} (increase of phosphorylation) | TRAF6(h) --> ERK1(h){p} (increase of phosphorylation) | TRAF6(h) --> ERK2(h){p} (increase of phosphorylation) | TRAF6(h) --> p38(h){p} (increase of phosphorylation) | TRAF6(h) + n ubiquitin(h) --> TRAF6(h){ub}n (ubiquitination) | CIKS(m.s.) + IL-17RA(m.s.) + TRAF6(h) <==> CIKS(m.s.):IL-17RA(m.s.):TRAF6(h) (binding) | IRAK(h) + TRAF6(h) <==> IRAK(h):TRAF6(h) (binding) | IRAK1(h){ub{K63}(n)} + TAK1(h) + TRAF6(h) + IKK-gamma(h) <==> IRAK1(h){ub{K63}(n)}:TAK1(h):TRAF6(h):IKK-gamma(h) (binding) | TRAF6(h) + CARD11(h) <==> TRAF6(h):CARD11(h) (binding) | IL-17RA(h) + TRAF6(h) + CIKS(h) <==> IL-17RA(h):TRAF6(h):CIKS(h) (binding) | SIGIRR-isoform1(h) + TRAF6(h) <==> SIGIRR-isoform1(h):TRAF6(h) (binding) | IL-1RI(m.s.) + TRAF6(h) <==> IL-1RI(m.s.):TRAF6(h) (binding) | TRAF6(h) --> TNF(h) (transactivation) | TRAF6(h) --> IL8(h) (transactivation) | TRAF6(h) + TIRAP(h) <==> TRAF6(h):TIRAP(h) (binding) | TRAF6(h) + IL-17RA(m.s.) <==> TRAF6(h):IL-17RA(m.s.) (binding) | TRAF6(h) --> DEFB4(h) (transactivation) | TRAF6(h) --IRAK1(h){p}--> TRAF6(h) (translocation) | TRAF6(h) --> TRAF6(h) (expression). | RIP2(m.s.) + n ubiquitin(m.s.) --TRAF6(h)--> RIP2(m.s.){ub}n (ubiquitination) | IL-17RA(h) + n ubiquitin(h) --TRAF6(h)--> IL-17RA(h){ub}n (ubiquitination) | TAK1(m.s.) + n ubiquitin(m.s.) --TRAF6(h)--> TAK1(m.s.){ub}n (ubiquitination) | TRAF6(h) + Pellino3-isoform1(h) <==> TRAF6(h):Pellino3-isoform1(h) (binding) | TRAF6(h) + Pellino3-isoform2(h) <==> TRAF6(h):Pellino3-isoform2(h) (binding) | TRAF6(h) + Irak1-b(h) <==> TRAF6(h):Irak1-b(h) (binding) | IRAK1-a(h) + TRAF6(h) <==> IRAK1-a(h):TRAF6(h) (binding) | Ubc13(h) + TRAF6(h) <==> Ubc13(h):TRAF6(h) (binding) | TRAF6(h) + p75NTR(r) <==> TRAF6(h):p75NTR(r) (binding) | IRF-7(m) + TRAF6(h) <==> IRF-7(m):TRAF6(h) (binding) | Syntenin(h) + TRAF6(h) <==> Syntenin(h):TRAF6(h) (binding) | TRAF6(h) --> TRAF6(h) (expression). | IRF-7(m) + n ubiquitin(m) --TRAF6(h),Ubc13(h)--> IRF-7(m){ub(n)} (ubiquitination) | TAK1a(h) + n ubiquitin(h) --TRAF6(h)--> TAK1a(h){ubK158}n (ubiquitination) | TAK1a(h) + ubiquitin(h) --TRAF6(h)--> TAK1a(h){ub{K63}(n)K158} (ubiquitination) | TRAF6(h) --> TRAF6_1(h) (expression). | hsa-miR-146a --/ TRAF6_1(h) (predicted) | hsa-miR-146b --/ TRAF6_1(h) (predicted) | TRAF6(h) --> TRAF6_2(h) (expression). | hsa-miR-146a --/ TRAF6_2(h) (predicted) | hsa-miR-146b --/ TRAF6_2(h) (predicted) | TRAF6(h) --> TRAF6(h) (expression). | hsa-miR-146a --/ TRAF6(h) (increase of mRNA decay). | hsa-miR-146b --/ TRAF6(h) (increase of mRNA decay). |
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Post Translational Modification [Top] | |||
There is no record for TRAF6 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 36487898 - 36489898 | Agilent_014791 |
chr11 |
Promoter: 36487898 - 36489898 | GSE27584 |
chr11 |
Promoter: 36487898 - 36489898 | GSE27584 |
chr11 |
Promoter: 36487898 - 36489898 | Agilent_014791_44K |