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Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

7189

Name

TRAF6

Synonymous

TNF receptor-associated factor 6, E3 ubiquitin protein ligase;TRAF6;TNF receptor-associated factor 6, E3 ubiquitin protein ligase

Definition

E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer

Position

11p12

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 BCL10NCI_NATURE;

in same component

 BCL10REACTOME;

in same component

 BDNFNCI_NATURE;

in same component

 CARD11NCI_NATURE;

in same component

 CARD11REACTOME;

in same component

 CBLBNCI_NATURE;

in same component

 CD40LGNCI_NATURE;

in same component

 CD40NCI_NATURE;

in same component

 CHUKREACTOME;

in same component

 IKBKBREACTOME;

in same component

 IKBKGREACTOME;

in same component

 IL1R1REACTOME;

in same component

 IRAK1NCI_NATURE;

in same component

 IRAK1REACTOME;

in same component

 IRAK2REACTOME;

in same component

 IRAK4REACTOME;

in same component

 IRF7REACTOME;

in same component

 LY96REACTOME;

in same component

 MALT1NCI_NATURE;

in same component

 MALT1REACTOME;

in same component

 MAP3K1REACTOME;

in same component

 MAP3K3NCI_NATURE;

in same component

 MAP3K3REACTOME;

in same component

 MAP3K5NCI_NATURE;

in same component

 MAP3K7NCI_NATURE;

in same component

 MAP3K7REACTOME;

in same component

 MYD88REACTOME;

in same component

 NFKB1REACTOME;

in same component

 NGFRNCI_NATURE;

in same component

 NGFRREACTOME;

in same component

 NGFNCI_NATURE;

in same component

 NGFREACTOME;

in same component

 NTF4NCI_NATURE;

in same component

 PDPK1NCI_NATURE;

in same component

 PDPK1REACTOME;

in same component

 PRKCIREACTOME;

in same component

 RELAREACTOME;

in same component

 RIPK2NCI_NATURE;

in same component

 SORT1NCI_NATURE;

in same component

 SQSTM1NCI_NATURE;

in same component

 SQSTM1REACTOME;

in same component

 TAB1NCI_NATURE;

in same component

 TAB1REACTOME;

in same component

 TAB2NCI_NATURE;

in same component

 TAB2REACTOME;

in same component

 TAB3CELL_MAP;

in same component

 TICAM1REACTOME;

in same component

 TICAM2REACTOME;

in same component

 TIRAPREACTOME;

in same component

 TLR3REACTOME;

in same component

 TLR4REACTOME;

in same component

 TOLLIPREACTOME;

in same component

 UBE2NREACTOME;

in same component

 UBE2V1REACTOME;

in same component

 ZNF274NCI_NATURE;

interacts with

 ACTG1MINT;

interacts with

 ATP2A2MINT;

interacts with

 ATP6V1E1HPRD;

interacts with

 BCL10MINT;

interacts with

 BIRC2HPRD;

interacts with

 BIRC3HPRD;

interacts with

 BMPR1BBIOGRID;

interacts with

 BMPR1BHPRD;

interacts with

 BRI3BPMINT;

interacts with

 CALM1MINT;

interacts with

 CAMLGINTACT;

interacts with

 CAV1HPRD;

interacts with

 CBLHPRD;

interacts with

 CCL20MINT;

interacts with

 CD40BIOGRID;

interacts with

 CD40HPRD;

interacts with

 CD40INTACT;

interacts with

 CTPSBIOGRID;

interacts with

 CYLDBIOGRID;

interacts with

 CYLDHPRD;

interacts with

 DDX3XBIOGRID;

interacts with

 DNAJA1MINT;

interacts with

 EcsitBIOGRID;

interacts with

 ECSITHPRD;

interacts with

 EDA2RBIOGRID;

interacts with

 EDA2RHPRD;

interacts with

 EDARADDHPRD;

interacts with

 EDARHPRD;

interacts with

 EEF1A2MINT;

interacts with

 EIF2AK2HPRD;

interacts with

 EIF4E2BIOGRID;

interacts with

 EPPK1BIOGRID;

interacts with

 ERLIN1MINT;

interacts with

 FANCD2MINT;

interacts with

 FHL2BIOGRID;

interacts with

 FHL2HPRD;

interacts with

 GANABBIOGRID;

interacts with

 HADHAMINT;

interacts with

 HSPA1LMINT;

interacts with

 HSPA4BIOGRID;

interacts with

 HSPA4HPRD;

interacts with

 HSPA5MINT;

interacts with

 HSPA8MINT;

interacts with

 HSPA9MINT;

interacts with

 HSPB2BIOGRID;

interacts with

 IARSBIOGRID;

interacts with

 IKBKGBIOGRID;

interacts with

 IL17RABIOGRID;

interacts with

 IL17RBHPRD;

interacts with

 IPO7MINT;

interacts with

 IRAK1BIOGRID;

interacts with

 IRAK1HPRD;

interacts with

 IRAK1MINT;

interacts with

 IRAK2BIOGRID;

interacts with

 IRAK2HPRD;

interacts with

 IRAK2MINT;

interacts with

 IRAK3BIOGRID;

interacts with

 IRAK3HPRD;

interacts with

 IRAK3MINT;

interacts with

 IRAK4BIOGRID;

interacts with

 IRAK4HPRD;

interacts with

 IRF5HPRD;

interacts with

 IRF7BIOGRID;

interacts with

 IRF7HPRD;

interacts with

 IRF8BIOGRID;

interacts with

 IRF8HPRD;

interacts with

 KCNQ1BIOGRID;

interacts with

 KCNQ1CELL_MAP;

interacts with

 KCNQ1HPRD;

interacts with

 KCNQ1MINT;

interacts with

 KPNB1MINT;

interacts with

 MALT1BIOGRID;

interacts with

 MALT1HPRD;

interacts with

 MALT1MINT;

interacts with

 MAP2K1HPRD;

interacts with

 MAP2K4HPRD;

interacts with

 MAP2K6HPRD;

interacts with

 MAP2K7HPRD;

interacts with

 MAP3K14BIOGRID;

interacts with

 MAP3K14CELL_MAP;

interacts with

 MAP3K14HPRD;

interacts with

 MAP3K3HPRD;

interacts with

 MAP3K5BIOGRID;

interacts with

 MAP3K5HPRD;

interacts with

 Map3k7BIOGRID;

interacts with

 MAP3K7BIOGRID;

interacts with

 MAP3K7HPRD;

interacts with

 MAP3K7MINT;

interacts with

 MAP3K8HPRD;

interacts with

 MAPK14HPRD;

interacts with

 MAPK8HPRD;

interacts with

 MARCH5BIOGRID;

interacts with

 MAST2BIOGRID;

interacts with

 MAST2HPRD;

interacts with

 MAVSHPRD;

interacts with

 MBPHPRD;

interacts with

 MCM7BIOGRID;

interacts with

 MTHFD1BIOGRID;

interacts with

 MYD88HPRD;

interacts with

 MYD88INTACT;

interacts with

 NASPBIOGRID;

interacts with

 NGFRAP1HPRD;

interacts with

 NGFRBIOGRID;

interacts with

 NGFRHPRD;

interacts with

 NgfrINTACT;

interacts with

 NR2C2CELL_MAP;

interacts with

 NTRK2BIOGRID;

interacts with

 NUMBLBIOGRID;

interacts with

 OTUD7BBIOGRID;

interacts with

 OTUD7BHPRD;

interacts with

 PAICSBIOGRID;

interacts with

 PARP1MINT;

interacts with

 PEBP1MINT;

interacts with

 PELI3BIOGRID;

interacts with

 PELI3HPRD;

interacts with

 PFASBIOGRID;

interacts with

 PPP4CBIOGRID;

interacts with

 PPP4CHPRD;

interacts with

 PRKCZBIOGRID;

interacts with

 PRKCZHPRD;

interacts with

 PSEN1BIOGRID;

interacts with

 PSMA1MINT;

interacts with

 PSMA4MINT;

interacts with

 PSMB2MINT;

interacts with

 PSMB5BIOGRID;

interacts with

 PSMB5CELL_MAP;

interacts with

 PSMB5HPRD;

interacts with

 PSMB5MINT;

interacts with

 PSMB6MINT;

interacts with

 PSMC1BIOGRID;

interacts with

 PSMC1CELL_MAP;

interacts with

 PSMC1HPRD;

interacts with

 PSMC1MINT;

interacts with

 PSMC2BIOGRID;

interacts with

 PSMC2CELL_MAP;

interacts with

 PSMC2HPRD;

interacts with

 PSMC2MINT;

interacts with

 PSMC3BIOGRID;

interacts with

 PSMC3CELL_MAP;

interacts with

 PSMC3HPRD;

interacts with

 PSMC3MINT;

interacts with

 PSMC5MINT;

interacts with

 PSMC6MINT;

interacts with

 PSMD11MINT;

interacts with

 PSMD12BIOGRID;

interacts with

 PSMD12CELL_MAP;

interacts with

 PSMD12HPRD;

interacts with

 PSMD12MINT;

interacts with

 PSMD13BIOGRID;

interacts with

 PSMD13CELL_MAP;

interacts with

 PSMD13HPRD;

interacts with

 PSMD13MINT;

interacts with

 PSMD1BIOGRID;

interacts with

 PSMD1CELL_MAP;

interacts with

 PSMD1HPRD;

interacts with

 PSMD1MINT;

interacts with

 PSMD2MINT;

interacts with

 PSMD3BIOGRID;

interacts with

 PSMD3CELL_MAP;

interacts with

 PSMD3HPRD;

interacts with

 PSMD3MINT;

interacts with

 PSMD4MINT;

interacts with

 PSMD6CELL_MAP;

interacts with

 PSMD6HPRD;

interacts with

 PSMD6MINT;

interacts with

 PSMD7BIOGRID;

interacts with

 PSMD7CELL_MAP;

interacts with

 PSMD7HPRD;

interacts with

 PSMD7MINT;

interacts with

 PSMD8MINT;

interacts with

 PTPN6HPRD;

interacts with

 RANBP9BIOGRID;

interacts with

 RCN2MINT;

interacts with

 RIPK2BIOGRID;

interacts with

 RIPK2HPRD;

interacts with

 RNF126MINT;

interacts with

 SDCBPBIOGRID;

interacts with

 SIGIRRBIOGRID;

interacts with

 SIGIRRHPRD;

interacts with

 SOCS3BIOGRID;

interacts with

 SPHK1HPRD;

interacts with

 SPHK1MINT;

interacts with

 SPOPBIOGRID;

interacts with

 SQSTM1BIOGRID;

interacts with

 SQSTM1HPRD;

interacts with

 SQSTM1MINT;

interacts with

 SRCBIOGRID;

interacts with

 SRCHPRD;

interacts with

 STRADBBIOGRID;

interacts with

 STRADBHPRD;

interacts with

 SYKBIOGRID;

interacts with

 SYKHPRD;

interacts with

 TAB1BIOGRID;

interacts with

 TAB2BIOGRID;

interacts with

 TAB2CELL_MAP;

interacts with

 TAB2HPRD;

interacts with

 TAB3BIOGRID;

interacts with

 TAB3CELL_MAP;

interacts with

 TAB3HPRD;

interacts with

 TARSBIOGRID;

interacts with

 TAX1BP1BIOGRID;

interacts with

 TAX1BP1MINT;

interacts with

 TDP2BIOGRID;

interacts with

 TDP2HPRD;

interacts with

 TGFBR1BIOGRID;

interacts with

 TICAM1HPRD;

interacts with

 TICAM2HPRD;

interacts with

 TIFABIOGRID;

interacts with

 TIFAHPRD;

interacts with

 TIRAPHPRD;

interacts with

 TJP2BIOGRID;

interacts with

 TLR3HPRD;

interacts with

 TNFAIP3BIOGRID;

interacts with

 TNFAIP3HPRD;

interacts with

 TNFRSF11ABIOGRID;

interacts with

 TNFRSF11AHPRD;

interacts with

 TNFRSF13BBIOGRID;

interacts with

 TNFRSF13BHPRD;

interacts with

 TNFRSF13BINTACT;

interacts with

 TNFRSF17INTACT;

interacts with

 TNFRSF19HPRD;

interacts with

 TNFSF11HPRD;

interacts with

 TRAF2BIOGRID;

interacts with

 TRAF2HPRD;

interacts with

 TRAF2INTACT;

interacts with

 TRAF2MINT;

interacts with

 TRAF3IP1BIOGRID;

interacts with

 TRAF3IP2HPRD;

interacts with

 TRAF4HPRD;

interacts with

 TRAF5INTACT;

interacts with

 TRAF7HPRD;

interacts with

 TRAFD1HPRD;

interacts with

 TRAIPBIOGRID;

interacts with

 TRAM1HPRD;

interacts with

 TRIM37BIOGRID;

interacts with

 TUBA3CMINT;

interacts with

 TUBB2BMINT;

interacts with

 TUBB4MINT;

interacts with

 TUBB6MINT;

interacts with

 TUBBMINT;

interacts with

 UBE2D1BIOGRID;

interacts with

 UBE2D2BIOGRID;

interacts with

 UBE2D3BIOGRID;

interacts with

 UBE2D4BIOGRID;

interacts with

 UBE2NBIOGRID;

interacts with

 UBE2NHPRD;

interacts with

 UBE2V1BIOGRID;

interacts with

 UBE2V1HPRD;

interacts with

 UEVLDBIOGRID;

interacts with

 USP7BIOGRID;

interacts with

 USP7HPRD;

interacts with

 VARSBIOGRID;

interacts with

 VCPBIOGRID;

interacts with

 VCPMINT;

interacts with

 VDAC1BIOGRID;

interacts with

 XIAPBIOGRID;

interacts with

 XIAPHPRD;

interacts with

 ZFAND5BIOGRID;

interacts with

 ZFAND5CELL_MAP;

interacts with

 ZFAND5HPRD;

interacts with

 ZMYND11BIOGRID;

interacts with

 ZMYND11MINT;

interacts with

 ZNF675BIOGRID;

interacts with

 ZRANB1BIOGRID;

interacts with

 ZRANB1HPRD;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

sequential catalysis

 BCL10REACTOME;

sequential catalysis

 CARD11REACTOME;

sequential catalysis

 IRAK1REACTOME;

sequential catalysis

 IRAK4REACTOME;

sequential catalysis

 IRF7REACTOME;

sequential catalysis

 MALT1REACTOME;

sequential catalysis

 MYD88REACTOME;

sequential catalysis

 PDPK1REACTOME;

sequential catalysis

 TRAF6REACTOME;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 BCL10NCI_NATURE;

reacts with

 BCL10REACTOME;

reacts with

 BDNFNCI_NATURE;

reacts with

 BEX1NCI_NATURE;

reacts with

 CARD11NCI_NATURE;

reacts with

 CARD11REACTOME;

reacts with

 CBLBNCI_NATURE;

reacts with

 CD40LGNCI_NATURE;

reacts with

 CD40NCI_NATURE;

reacts with

 CHUKREACTOME;

reacts with

 IKBKBREACTOME;

reacts with

 IKBKGREACTOME;

reacts with

 IL1ANCI_NATURE;

reacts with

 IL1BNCI_NATURE;

reacts with

 IL1R1NCI_NATURE;

reacts with

 IL1R1REACTOME;

reacts with

 IRAK1NCI_NATURE;

reacts with

 IRAK1REACTOME;

reacts with

 IRAK2REACTOME;

reacts with

 IRAK4NCI_NATURE;

reacts with

 IRAK4REACTOME;

reacts with

 IRF7REACTOME;

reacts with

 LY96REACTOME;

reacts with

 MALT1NCI_NATURE;

reacts with

 MALT1REACTOME;

reacts with

 MAP3K1REACTOME;

reacts with

 MAP3K3NCI_NATURE;

reacts with

 MAP3K3REACTOME;

reacts with

 MAP3K5NCI_NATURE;

reacts with

 MAP3K7NCI_NATURE;

reacts with

 MAP3K7REACTOME;

reacts with

 MYD88NCI_NATURE;

reacts with

 MYD88REACTOME;

reacts with

 NFKB1REACTOME;

reacts with

 NGFRNCI_NATURE;

reacts with

 NGFRREACTOME;

reacts with

 NGFNCI_NATURE;

reacts with

 NGFREACTOME;

reacts with

 NTF4NCI_NATURE;

reacts with

 PDPK1NCI_NATURE;

reacts with

 PDPK1REACTOME;

reacts with

 PRKCIREACTOME;

reacts with

 RELAREACTOME;

reacts with

 RIPK2NCI_NATURE;

reacts with

 SORT1NCI_NATURE;

reacts with

 SQSTM1NCI_NATURE;

reacts with

 SQSTM1REACTOME;

reacts with

 TAB1NCI_NATURE;

reacts with

 TAB1REACTOME;

reacts with

 TAB2NCI_NATURE;

reacts with

 TAB2REACTOME;

reacts with

 TICAM1REACTOME;

reacts with

 TICAM2REACTOME;

reacts with

 TIRAPREACTOME;

reacts with

 TLR3REACTOME;

reacts with

 TLR4REACTOME;

reacts with

 TOLLIPNCI_NATURE;

reacts with

 TOLLIPREACTOME;

reacts with

 TRAF2NCI_NATURE;

reacts with

 TRAF6NCI_NATURE;

reacts with

 TRAF6REACTOME;

reacts with

 TXNNCI_NATURE;

reacts with

 UBE2NREACTOME;

reacts with

 UBE2V1REACTOME;

reacts with

 ZNF274NCI_NATURE;

state change

 ADAM17NCI_NATURE;

state change

 APH1ANCI_NATURE;

state change

 APH1BNCI_NATURE;

state change

 BCL10REACTOME;

state change

 CARD11REACTOME;

state change

 CYLDCELL_MAP;

state change

 ECSITREACTOME;

state change

 IKBKBREACTOME;

state change

 IL1BNCI_NATURE;

state change

 IL1BREACTOME;

state change

 IL1R1NCI_NATURE;

state change

 IRAK1REACTOME;

state change

 IRAK2REACTOME;

state change

 IRAK3REACTOME;

state change

 IRAK4NCI_NATURE;

state change

 IRAK4REACTOME;

state change

 IRF7REACTOME;

state change

 LY96REACTOME;

state change

 MALT1REACTOME;

state change

 MAP3K7REACTOME;

state change

 MYD88NCI_NATURE;

state change

 MYD88REACTOME;

state change

 NCSTNNCI_NATURE;

state change

 NGFRREACTOME;

state change

 NGFREACTOME;

state change

 PDPK1REACTOME;

state change

 PSEN1NCI_NATURE;

state change

 PSENENNCI_NATURE;

state change

 PSENENREACTOME;

state change

 SQSTM1REACTOME;

state change

 TAB1REACTOME;

state change

 TAB2NCI_NATURE;

state change

 TAB2REACTOME;

state change

 TICAM1REACTOME;

state change

 TICAM2NCI_NATURE;

state change

 TICAM2REACTOME;

state change

 TLR3REACTOME;

state change

 TLR4REACTOME;

state change

 TRAF6REACTOME;

state change

 UBE2NNCI_NATURE;

state change

 UBE2V1NCI_NATURE;