| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7189 |
Name | TRAF6 |
Synonym | MGC:3310|RNF85;TNF receptor-associated factor 6, E3 ubiquitin protein ligase;TRAF6;TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer |
Position | 11p12 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Regulation of p38-alpha and p38-beta;PID Curated;200054 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | p75NTR signals via NF-kB;PID Reactome;500613 |
Pathway | p75NTR recruits signalling complexes;PID Reactome;500614 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | NF-kB is activated and signals survival;PID Reactome;500615 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | NRIF signals cell death from the nucleus;PID Reactome;500610 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Regulated proteolysis of p75NTR;PID Reactome;500620 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | yaci and bcma stimulation of b cell immune responses;PID BioCarta;100024 |
Pathway | Downstream TCR signaling;PID Reactome;500482 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | cd40l signaling pathway;PID BioCarta;100213 |
Pathway | TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade;PID Reactome;500449 |
Pathway | MyD88 cascade;PID Reactome;500445 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | bone remodeling;PID BioCarta;100052 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | p38 MAPK signaling pathway;PID Curated;200014 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Disease | Ectodermal dysplasia;FunDO |
Disease | Osteoporosis;FunDO |
Disease | Infection;FunDO |
External Links | |
Links to Entrez Gene | 7189 |
Links to all GeneRIF Items | 7189 |
Links to iHOP | 7189 |
Sequence Information | |
Nucleotide Sequence | >7189 : length: 8040 CTCCTCCCCGGCGCGCTCCCTGCCCCTCGCTCCCCGCAGCCAGCAGAGAAGGCGGAAGCA GTGGCGTCCGCAGCTGGGGCTTGGCCTGCGGGCGGCCAGCGAAGGTGGCGAAGGCTCCCA CTGGATCCAGAGTTTGCCGTCCAAGCAGCCTCGTCTCGGCGCGCAGTGTCTGTGTCCGTC CTCTACCAGCGCCTTGGCTGAGCGGAGTCGTGCGGTTGGTGGGGGAGCCCTGCCCTCCTG GTTCGGCCTCCCCGCGCACTAGAACGATCATGAACTTCTGAAGGGACCCAGCTTTCTTTG TGTGCTCCAAGTGATTTGCACAAATAATAATATATATATTTATTGAAGGAGAGAATCAGA GCAAGTGATAATCAAGTTACTATGAGTCTGCTAAACTGTGAAAACAGCTGTGGATCCAGC CAGTCTGAAAGTGACTGCTGTGTGGCCATGGCCAGCTCCTGTAGCGCTGTAACAAAAGAT GATAGTGTGGGTGGAACTGCCAGCACGGGGAACCTCTCCAGCTCATTTATGGAGGAGATC CAGGGATATGATGTAGAGTTTGACCCACCCCTGGAAAGCAAGTATGAATGCCCCATCTGC TTGATGGCATTACGAGAAGCAGTGCAAACGCCATGCGGCCATAGGTTCTGCAAAGCCTGC ATCATAAAATCAATAAGGGATGCAGGTCACAAATGTCCAGTTGACAATGAAATACTGCTG GAAAATCAACTATTTCCAGACAATTTTGCAAAACGTGAGATTCTTTCTCTGATGGTGAAA TGTCCAAATGAAGGTTGTTTGCACAAGATGGAACTGAGACATCTTGAGGATCATCAAGCA CATTGTGAGTTTGCTCTTATGGATTGTCCCCAATGCCAGCGTCCCTTCCAAAAATTCCAT ATTAATATTCACATTCTGAAGGATTGTCCAAGGAGACAGGTTTCTTGTGACAACTGTGCT GCATCAATGGCATTTGAAGATAAAGAGATCCATGACCAGAACTGTCCTTTGGCAAATGTC ATCTGTGAATACTGCAATACTATACTCATCAGAGAACAGATGCCTAATCATTATGATCTA GACTGCCCTACAGCCCCAATTCCATGCACATTCAGTACTTTTGGTTGCCATGAAAAGATG CAGAGGAATCACTTGGCACGCCACCTACAAGAGAACACCCAGTCACACATGAGAATGTTG GCCCAGGCTGTTCATAGTTTGAGCGTTATACCCGACTCTGGGTATATCTCAGAGGTCCGG AATTTCCAGGAAACTATTCACCAGTTAGAGGGTCGCCTTGTAAGACAAGACCATCAAATC CGGGAGCTGACTGCTAAAATGGAAACTCAGAGTATGTATGTAAGTGAGCTCAAACGAACC ATTCGAACCCTTGAGGACAAAGTTGCTGAAATCGAAGCACAGCAGTGCAATGGAATTTAT ATTTGGAAGATTGGCAACTTTGGAATGCATTTGAAATGTCAAGAAGAGGAGAAACCTGTT GTGATTCATAGCCCTGGATTCTACACTGGCAAACCCGGGTACAAACTGTGCATGCGCTTG CACCTTCAGTTACCGACTGCTCAGCGCTGTGCAAACTATATATCCCTTTTTGTCCACACA ATGCAAGGAGAATATGACAGCCACCTCCCTTGGCCCTTCCAGGGTACAATACGCCTTACA ATTCTTGATCAGTCTGAAGCACCTGTAAGGCAAAACCACGAAGAGATAATGGATGCCAAA CCAGAGCTGCTTGCTTTCCAGCGACCCACAATCCCACGGAACCCAAAAGGTTTTGGCTAT GTAACTTTTATGCATCTGGAAGCCCTAAGACAAAGAACTTTCATTAAGGATGACACATTA TTAGTGCGCTGTGAGGTCTCCACCCGCTTTGACATGGGTAGCCTTCGGAGGGAGGGTTTT CAGCCACGAAGTACTGATGCAGGGGTATAGCTTGCCCTCACTTGCTCAAAAACAACTACC TGGAGAAAACAGTGCCTTTCCTTGCCCTGTTCTCAATAACATGCAAACAAACAAGCCACG GGAAATATGTAATATCTACTAGTGAGTGTTGTTAGAGAGGTCACTTACTATTTCTTCCTG TTACAAATGATCTGAGGCAGTTTTTTCCTGGGAATCCACACGTTCCATGCTTTTTCAGAA ATGTTAGGCCTGAAGTGCCTGTGGCATGTTGCAGCAGCTATTTTGCCAGTTAGTATACCT CTTTGTTGTACTTTCTTGGGCTTTTGCTCTGGTGTATTTTATTGTCAGAAAGTCCAGACT CAAGAGTACTAAACTTTTAATAATAATGGATTTTCCTTAAAACTTCAGTCTTTTTGTAGT ATTATATGTAATATATTAAAAGTGAAAATCACTACCGCCTTGTGCTAGTGCCCTCGAGAA GAGTTATTGCTCTAGAAAGTTGAGTTCTCATTTTTTTAACCTGTTATAGATTTCAGAGGA TTTGAACCATAATCCTTGGAAAACTTAAGTTCTCATTCACCCCAGTTTTTCCTCCAGGTT GTTACTAAGGATATTCAGGGATGAGTTTAAACCCTAAATATAACCTTAATTATTTAGTGT AAACATGTCTGTTGAATAATACTTGTTTAAGTGTTCCTTCTGCCTTGCTTACTTATTTCC TTGAGGTTACGAAGTAGCATCTTCCCCAGAGTTTATAATGCTGAGAACCACGTGGATACC AACTGCTCATTGTTATGCTATGTAACCCTTTTTGTCTATTCAGTGCAGAGTGAATTTCAC AGCTCTGCATATGTCTTCATTTGTTTAATGCTTACAAGACAGGAGATGCACACATACAAT CAGCAACATAAAAATTAAAAGTGACCCAAGTAGTCAGCGCATGTGGCATCTCATTGGTGG TGACAGAAGCTATGTGAGCCAGAAGTTTTCAGCTCTTTTGAATACCCTCTGGTTTATTTC GATTAAAAAGAACAAAATTGATTTCCTAAAATCAGAATTTTTTAAAACTTGGGAGATGAT TGGAGATACCTAGGAGGTCACCAAACTAGGATTAGAAGTCACAGTGGTTGTATCACAACT TAGCTTGAGTATGTTGCTGTAGCCTAACAACTGCAGGTTCTGAGAAGGATCCTGTAGAAT CCTGGAAGTAACCAGATTTTCCTAATAGGGAGATGATTTTTTTGTGTGCCATCATGTATT TGTTAAAGGCCTATATATAGATATAAAATATCGTGGAATCTAGTTCTCAGGGAGACCCGC AACTAGTATAAGCTTATAAAGGATCTAAAGATCCATCCACCATTTAAAGTTGTCTGGTAA TGAGAGATGACATTGTATCCCCCAGAGAGGCCAAATCAGAGTCGCCAGCCAGCGTTCTAG ATCAGCCTTAATTTCAAGAGAAAGCCAAGGACCTCATCTGCAGGGGAGTGTGGTTTTCAG CCCCAGCGAGTGTCACTTTGAACTTTCCCTTTGCTTTTTTCTCTCTTCTCCCTCCCCACC CACCCTTAGGCTCCTGATCTGGTGAGTTTGTTATGGAGTGAAAATAAAAGTCAAGCAGAG ACCTTGTTTCCCGTGCCACCATTAGTACCACAAGCTCATGGCTAGTTACCACATTACTTC CTGGCAGTTTGTGTCCCTCAGCTGTGCCTTCCAACCAGCGCCTGAGAATCACTGCATACC ACCCTCTAGGTAGGGAAACCTACACTGCTGCTGTTCCTGTGATTATTTTACAATGAATAA ATAATTGTCAAGTTCCATTTAAAAACTGAACAGTAGTATTTTTGTATTTGCGTAGAAAAA GCCTGAAGGAAATATACTAAACTTTTTGTTGGCTTATTTTCCTTTGCGCTTGCTTATATT TTTTACATTTTCTACAATAAATGTGTACTTTTATCGGAGAAAAAAATTAAATGTTGCCAC AAAACATTTAATCTCCACGCCCCCAGCTCAAAAAAGGAAATGATATTTAAAAGCTTCCTG GTCAGATTTCTATTAAAAGCACTGGCTGTGCATTAGATACAAAGAGGAGTCATTTCCTGC CTTGGTGATACTATTTTTTTCTACTAACTCAAGAGTCTTTATTAAAAAAAAAAGTTGTTT TGCCTAATTTCAGCTTTTAGCAAGCTTCCCATCTGTAAAATGATTTGGACCAGATATTTC TAGAGTCCCCTCCAGCCATAACATTCTGTCTCAAATTAAGTTCCAACCAGCAGAACAATG ACAATACTTAGGAAAGTATTTTGCCAGTATAAAATGTCTTTAACTTACTCTTTGCTGACA CTGATACTTTCCTCTAATTTAGTGTCTATCAGCTGGGTCACATCTTAAGTAAAATGAGCA ATTTTAACCCCCAACATTTGGCATTTTGTCATAAACCAGCCAGTTATTTTATGCTGGTCA TTCATCTTGACTACAAAGTAGAATAGTCAAGCTGTCATTCCAAATAGAAAACTTTTTACT TCAATCAGAATTAAGCCTTAACCTGGAAAGTTGGTTTCTTCCTTACATTTTCCCAATCTC CTACTCTATTCTTAAACATGCTAGTTTCACTCAGTTGGGTATACAAGCCTTTGGGCTTTA TGTTGTATGTTACTAACCACCTTTTACCATATTTATCTTTTGGCATCATTCTGGGACATT GCTAAATTAAAAAAGAAATTGTTTCCACTTTTTTCTGGAGATGTTCAACTAAAGGTTGTT TTGTTTTGTTTTTTGTTTTGAGACAGTCTCACCCTGACGCTCAGGCTGGAGTGCAGTGGT GCAACCTCGGCTCACTGCAACCTCCACCTCCCGGGCTCAAGCCATTCTCCTGCCTCAGCC TCCCAAGCAGCTGGGATTACAGGCACCCGCCACCACGCCCAGCTAATTTTTTTGTATTTT GAGTAGAGACCGGGTTTCACCATATTGGCCAGTCTCGTCTGGAACTCCTGACCTCAGATG ATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGC GTCCAACCCACTGTTGGATGAAACTTGCTGCACGTCATACATTTTGCTGTTGGCAAACAA GTCTGAATGTTGATTTGAAGTTTGGTAGTTTATTACTATCTATTGGCAGCAAAGACTGTT TATTGGTATACTACAATATGATTTAACTTTTATTTTGGGGATAAATAGTAGAAAAAAGTG AAACAGAATGAAGGCAGGTGTTTTTTATTCTAATGATGGAATAATACAGAGATACTGGAC GATCTCTAGCAGTTAATTATTGTGACCCATATAAAATTATACAGGTCACAGTATAATTCT CTATTACCGTTTTTACACCAGTAAGTCTTAGATAAACTAAGCATGCTTATGAATTATGTA TACAGTTAGAATGCATTATTTTTACAGAGGAACAATTGCTTGTATGTACTAACACTGTTC TCTTGGCTTGCCTCAAGTTCTACTCATTATTTTATATAAAATACTATTAGGCTGGGCACG GTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGTGGAGGCTGGCGGATTACTTGAAGC CAGGAGTTCGAGACCAGCCTGGCCAAAATGGTGAAACCCCATCTCTATAAAAATACAAAA ATTAGCCAGGTGTCATGATACATGCCTGTAATCCCAGCTTCTTGGGAGGCTGAGGCACGG GAATCGCTTGAACCCGGGAAGCACAGGTTGCAGTGAGCCAAGATCATGCCACTGCACCCC CAGCCTGGGTGACAGAGTGCAACACTGTCTCACAAAACAAAACAAAAACATCAGATTCTG TTTGTGATGCCTAGTTGCTTACAACCTAAACAGTGCAATGCCTTAAGGAAATGAAAAGGA GCCATAAGTAGTCATTTATATTTTTATTTTGAAGTGTGCTTTTTCTAAACTCCCAGATTG ACATGATGGACTGTAAGTTAGTTTCTCTGTTTCTGTCTTTGTGCCTGTAGAGTGTACTTG GCACTTACAAATTCCCAGTATCCAGAAAGATGATCTGATGAAATCAAATTGGATGGATCT TGGCAGACTGTGACACTCAATTACAGCCTTCACTTTCAGTCAAAAACGGACACTTGGCAA GGAGGTGCCTGGTTGTTTCACTAAATGTCACTTGTGTGTGTAATATTTTAAAGCTTTTTC CCCACAGGAAATTCGGGTCATAAAATCCTGAAAAATAATTCTAGGTGGGAAAAGCATTTT AGGAAATGAGAGATGTGGTGCTGCTTTTCTTCTCTCAGAGTGCTTTCTCAGCAGGACACT AGCCCTGCCTTTAAGATGGGGAAGTTGGGGCATGTGCCTCTGCTCTTACTGTCTGCAGCT CTGAAGGTAGGTGCTGTCCCACTCGGACAATCGCCCAAGCAGCAGTGACCATAGTTCTCT TCTATGCAAGTCCCCAGGAGAAGGTAAACTGTGTGGAATGGGGATGTGTTCTGGTTGCTG CTGAATCCCCTCTTCTTACCACAGTGCCTGGCACGTTGCACACACTCAAATACGTAATAA TGAACATTTATTGAAAGCAGCAGTTGAAGCTGACCAATTTCTGGTACCTTGTCATGTAAA TTTTAGATGGTAAGGCGCAGATGTTACTTTTTTTGCTTTTTTTCTTCAGCACTTGATGAA ATTTCCCAAACATGCAGAAATGTTGAAAGACTTGTATAGTGAACATCTACGACCTAGAAT CTGCAGTAATATTATGTTACATTTGCTTTATCACTTGATAGATGTTACTTTTAATGAGAC TTCAAGTTTGGTTTCTCTAAACAAAATATTCTAAAATAACTGAACAACTTTAATCAATTT GTCTTAAGTTCTTTGGGGGAACTTGGGACATTTGCTTTGTAACTGGAATTGCAGCCCTCA CGTTAAGCTAATTTTAAACTTTGCAAATTTGTTATGCTGAATTTCAGTCTTATTTATTTT GCCTGAAGGGGTATTTTTTGTAATGGATTTATTTGAAGGTCCTTGATAAATTGTGCAGAA TATTCTCGTGTTCTTTTTGCACTTGATAAATTATCTAATTTCTGTGGTGAGAATGTAATT TGGGGCCTATTTTGTTTATACAAGCTTCCAGAATTATGTTCTCAGAGGGATGAAAAGGTG TAATTTAGCATATAGGTCACTAAATTAGGAGCTAAGACACATTTTCTCCTGACTGACCAT GGGTCAATCAGTTTTGTCTTCGTGTCCTTTTCCTTGTAAAGTAGAAACTAGAATTTGAAA TTTAAATATTAAATAATGGGTAACATTCATTAATGTATGACTCTATTAAGAAAGACACTG TGAATCCAGGGAGGATTCTCATAATTCTGTAAACTGTATGACAAGCTGTGGAATGAAATC TGACTTTTGAAAATTGAAAGACATCCAGTGGTCTTATCACAAAGCCTGCTTTTCCTCAGA ACTTAACTATTGCCATGGAATTTGTAAGCAGTTATCCTAATCCATCTGGACTCTGAAAAT GCATCCTTTATGAGAGGGAGTGAATGCAAAGATAAGGGTGGGGAAACACTAATCATGAAA AGAATGAAAATCAGTGTTCAGTTTTAAGAGCAGGTTGTATTGAAGGAAGGGATTAAAGGA ATTATCCAGATTTGAGGTGGCACATCTTCCACCACTCCCTGCACCATCAGCATGCACGGA GCGCATAAAACAAGCCCTGCTCCTAATGGCAGTGAAACCTCGGATGGCCTCCATCAGGTC AATACAACTGAATTGCTGGGCTGACTTAAGATTGAAGGACTCCATTTTAGTAAGTAGAGA AGTGTGACCTTTCTCAACCCAGGTTGTGAATGTGGATTCACACTTATCTCAAAAAGGCAC CTGGAGTTTTAACTTTATGTCATGTCTCAGTACTGGTTGCAAGGTATGACCAAAAGTGTT CCTTGAATGGCACCTTTTTGAATATTAATTTAGAAGAAAACATGCCAGACTGACATACTT ACCCCCTCCGCACTGTTACTACTTCCTTACCAGCCCTATGTACTGCATCAATGTCTACAA GAAAGCACTCTTCATTAAAATGAAATATATATATTAAAATAAAAAAAAAAAAAAAAAAAA |
Protein Sequence | >7189 : length: 522 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV |