| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5829 |
Name | PXN |
Synonymous | paxillin;PXN;paxillin |
Definition | - |
Position | 12q24.31 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Pyk2-isoform1(h) + paxillin(h) <==> Pyk2-isoform1(h):paxillin(h) (binding) | FAK1(h) + paxillin(h) <==> FAK1(h):paxillin(h) (binding) | paxillin(h) + actopaxin(h) <==> paxillin(h):actopaxin(h) (binding) | PTP-PEST(m) + paxillin(h) <==> PTP-PEST(m):paxillin(h) (binding) | Bcl-2(m) + paxillin(h) <==> Bcl-2(m):paxillin(h) (binding) | Bcl-2(m.s.) + paxillin(h) + ILK(m) + PTP-PEST(m) + Csk(m) + crk(m) + vinculin(m) + FAK1(m) <==> Bcl-2(m.s.):paxillin(h):ILK(m):PTP-PEST(m):Csk(m):crk(m):vinculin(m):FAK1(m) (binding) | paxillin(h) --> p190RhoGAP(mo):RasGAP(mo) (decrease of binding) | paxillin(h) --> RasGAP(m):p190RhoGAP(m) (decrease of binding) | paxillin(h) + ATP --> paxillin(h){pY} + ADP (phosphorylation) | paxillin(h) + trkA(h) <==> paxillin(h):trkA(h) (binding) | paxillin(h) + ATP --> paxillin(h){p} + ADP (phosphorylation) | Gab-1(h){pY} + paxillin(h) <==> Gab-1(h){pY}:paxillin(h) (binding) | paxillin(h) + SHP-2(h) <==> paxillin(h):SHP-2(h) (binding) | Src(h) + paxillin(h) <==> Src(h):paxillin(h) (binding) | paxillin(h) + Src(h){pY530} <==> paxillin(h):Src(h){pY530} (binding) | paxillin(h) + ATP --> paxillin(h){pY31} + ADP (phosphorylation) | trip6(m.s.) + paxillin(h) <==> trip6(m.s.):paxillin(h) (binding) | Pyk2(h){pY} + paxillin(h) <==> Pyk2(h){pY}:paxillin(h) (binding) | paxillin(h) + ATP --> paxillin(h){pY118} + ADP (phosphorylation) | PXN(h) --> paxillin(h) (expression). | paxillin(h){pY} --PTP1B(c)--> paxillin(h) + p (dephosphorylation) | paxillin(h){pY} --SHP-2(r)--> paxillin(h) + p (dephosphorylation) | PXN(h) --> paxillin-gamma(h) (expression). | paxillin-beta(h) + ATP --JNK1(m)--> paxillin-beta(h){pS178} + ADP (phosphorylation) | PXN(h) --> paxillin-beta(h) (expression). | paxillin-alpha(h) + alpha4-integrin(h) <==> paxillin-alpha(h):alpha4-integrin(h) (binding) | PXN(h) --> paxillin-alpha(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 31 | Phosphotyrosine. | Swiss-Prot 53.0 | 88 | Phosphotyrosine. | Swiss-Prot 53.0 | 106 | Phosphoserine. | Swiss-Prot 53.0 | 109 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 118 | Phosphotyrosine. | Swiss-Prot 53.0 | 181 | Phosphotyrosine. | Swiss-Prot 53.0 | 303 | Phosphoserine. | Swiss-Prot 53.0 | 40 | Phosphotyrosine (Src) | 11695992;16254239 | Phospho.ELM 6.0 | 31 | Phosphotyrosine (Abl;FAK;Src;) | 7537852;11774284;10823820;15107421;16254239;158174 | Phospho.ELM 6.0 | 88 | Phosphotyrosine (Src) | 11695992;16254239 | Phospho.ELM 6.0 | 181 | Phosphotyrosine | 11774284;16254239 | Phospho.ELM 6.0 | 118 | Phosphotyrosine (Abl;FAK;Src;) | 7537852;11774284;7615549;15592455;15107421;1625423 | Phospho.ELM 6.0 | 126 | Phosphoserine | 12837288 | Phospho.ELM 6.0 | 130 | Phosphoserine | 12837288 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 119187392 - 119189392 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 119187392 - 119189392 | GSE27584 |