| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5590 |
Name | PRKCZ |
Synonymous | protein kinase C, zeta;PRKCZ;protein kinase C, zeta |
Definition | nPKC-zeta|protein kinase C zeta type |
Position | 1p36.33-p36.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PKCzeta(h) + Pard6a(h):Rac1(h):GTP <==> PKCzeta(h):Pard6a(h):Rac1(h):GTP (binding) | Cdc42(h):GTP:Pard6a(h) + PKCzeta(h) <==> Cdc42(h):GTP:Pard6a(h):PKCzeta(h) (binding) | PKCzeta(h) + Keratin10(h) <==> PKCzeta(h):Keratin10(h) (binding) | PKCzeta(h) + Keratin10(h) + AKT(h) <==> PKCzeta(h):Keratin10(h):AKT(h) (binding) | PKCzeta(h) + Ajuba(h) + p62(h) <==> PKCzeta(h):Ajuba(h):p62(h) (binding) | TRAF6(h) + PKCzeta(h) + Ajuba(h) + p62(h) <==> TRAF6(h):PKCzeta(h):Ajuba(h):p62(h) (binding) | PKCzeta(h) + p65PAK(h) <==> PKCzeta(h):p65PAK(h) (binding) | MYH10(h) + PKCzeta(h) + p65PAK(m.s.) <==> MYH10(h):PKCzeta(h):p65PAK(m.s.) (binding) | MYH10(h) + PKCzeta(h) <==> MYH10(h):PKCzeta(h) (binding) | PKCzeta(h) --> PKCzeta(h) (translocation) | PKCzeta(h) + ATP --p65PAK(h)--> PKCzeta(h){p} + ADP (phosphorylation) | PKCzeta(h) + KIBRA-isoform1(h) <==> PKCzeta(h):KIBRA-isoform1(h) (binding) | PKCzeta(h) + Pard6a(h) <==> PKCzeta(h):Pard6a(h) (binding) | PKCzeta(h) + ATP --> PKCzeta(h){pT410} + ADP (phosphorylation) | PRKCZ(h) --> PKCzeta(h) (expression). | PKCzeta(h) --> PKCzeta(h) (translocation) | p47phox(h) + ATP --PKCzeta(h)--> p47phox(h){p} + ADP (phosphorylation; translocation) | IRAP(r) + ATP --PKCzeta(h)--> IRAP(r){pS} + ADP (phosphorylation) | cTnI(b):cTnT(b):TNNC(b) + 2 ATP --PKCzeta(h)--> cTnT(b){p}:cTnI(b){p}:TNNC(b) + 2 ADP (phosphorylation) | cTnI(b) + ATP --PKCzeta(h)--> cTnI(b){pS} + ADP (phosphorylation) | cTnT(b) + ATP --PKCzeta(h)--> cTnT(b){p} + ADP (phosphorylation) | MYH10(h) + ATP --PKCzeta(h)--> MYH10(h){pS1937} + ADP (phosphorylation) | FADD(h) + PKCzeta(h) <==> FADD(h):PKCzeta(h) (binding) | Ajuba(h) + PKCzeta(h) <==> Ajuba(h):PKCzeta(h) (binding) | PKCzeta(h) + ATP --> ADP + PKCzeta(h){p} (phosphorylation; automodification) | PRKCZ(h) --> PKCzeta(h) (expression). | FADD(h) + ATP --PKCzeta(h)--> FADD(h){p} + ADP (phosphorylation) | Ajuba(h) + ATP --PKCzeta(h)--> Ajuba(h){p} + ADP (phosphorylation) | CYP7(h) + ATP --PKCzeta(h)--> CYP7(h){p} + ADP (phosphorylation) | mybpc1(r) + 2 ATP --PKCzeta(h)--> mybpc1(r){pS}{pT} + 2 ADP (phosphorylation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 223 | Phosphoserine. | Swiss-Prot 53.0 | 410 | Phosphothreonine (by PDPK1). | Swiss-Prot 53.0 | 560 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 410 | Phosphothreonine (PDK-1) | 9748166;11222751 | Phospho.ELM 6.0 | 560 | Phosphothreonine (PKC zeta) | 9748166 | Phospho.ELM 6.0 | 223 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 2024515 - 2026515 | Agilent_014791 |
chr1 |
Promoter: 1970269 - 1972269 | Agilent_014791 |
chr1 |
Promoter: 2024515 - 2026515 | GSE27584 |
chr1 |
Promoter: 1993446 - 1995446 | GSE27584 |
chr1 |
Promoter: 1970269 - 1972269 | GSE27584 |
chr1 |
Promoter: 1970269 - 1972269 | Agilent_014791_44K |