Entrez Gene

Basic Information
Gene ID	5590
Name	PRKCZ
Synonymous	protein kinase C, zeta;PRKCZ;protein kinase C, zeta
Definition	nPKC-zeta\|protein kinase C zeta type
Position	1p36.33-p36.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.504C>T; p.V168V; 1:2144293-2144293	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.801C>T; p.L267L; 1:2150903-2150903	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1401C>T; p.F467F; 1:2174012-2174012	skin	malignant_melanoma	Substitution - coding silent
c.1261G>A; p.E421K; 1:2172364-2172364	breast	carcinoma	Substitution - Missense
c.1541C>T; p.S514F; 1:2175279-2175279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.463G>A; p.A155T; 1:2144252-2144252	prostate	carcinoma	Substitution - Missense
c.411C>T; p.R137R; 1:2135338-2135338	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.90C>T; p.S30S; 1:2055459-2055459	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.779G>A; p.R260H; 1:2150881-2150881	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.104C>T; p.T35M; 1:2055473-2055473	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.688-1G>A; p.?; 1:2150789-2150789	lung	carcinoma; adenocarcinoma	Unknown
c.309_311delTGG; p.G104delG; 1:2059566-2059568	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.309_311delTGG; p.G104delG; 1:2059566-2059568	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.768A>G; p.R256R; 1:2150870-2150870	skin	malignant_melanoma	Substitution - coding silent
c.554A>T; p.D185V; 1:2146028-2146028	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.554A>T; p.D185V; 1:2146028-2146028	urinary_tract; bladder	carcinoma	Substitution - Missense
c.388G>A; p.G130S; 1:2135315-2135315	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.562A>G; p.M188V; 1:2146036-2146036	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.A357T; 1:2172062-2172062	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1266C>T; p.I422I; 1:2172369-2172369	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1244C>T; p.P415L; 1:2172347-2172347	skin	malignant_melanoma	Substitution - Missense
c.588C>T; p.D196D; 1:2146062-2146062	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.688G>A; p.D230N; 1:2150790-2150790	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.376T>G; p.Y126D; 1:2135303-2135303	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.96C>T; p.D32D; 1:2055465-2055465	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.866A>G; p.H289R; 1:2150968-2150968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.E77K; 1:2056519-2056519	skin	malignant_melanoma	Substitution - Missense
c.1307C>T; p.A436V; 1:2173918-2173918	skin	malignant_melanoma	Substitution - Missense
c.690C>T; p.D230D; 1:2150792-2150792	large_intestine; rectum	NS	Substitution - coding silent
c.690C>T; p.D230D; 1:2150792-2150792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.653_654CC>TT; p.S218F; 1:2148890-2148891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1745A>G; p.N582S; 1:2184975-2184975	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.619G>A; p.E207K; 1:2146093-2146093	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.549T>A; p.H183Q; 1:2144338-2144338	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.622G>A; p.E208K; 1:2146096-2146096	breast	carcinoma	Substitution - Missense
c.552G>T; p.M184I; 1:2144341-2144341	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1278G>A; p.E426E; 1:2172381-2172381	skin	malignant_melanoma	Substitution - coding silent
c.1033C>A; p.Q345K; 1:2169576-2169576	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1218C>T; p.D406D; 1:2172321-2172321	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1201G>C; p.G401R; 1:2172304-2172304	breast	carcinoma	Substitution - Missense
c.425C>T; p.A142V; 1:2144214-2144214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1147C>T; p.L383F; 1:2172140-2172140	skin	malignant_melanoma	Substitution - Missense
c.1567T>G; p.W523G; 1:2175305-2175305	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.323C>T; p.P108L; 1:2059580-2059580	skin	malignant_melanoma	Substitution - Missense
c.816G>T; p.K272N; 1:2150918-2150918	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.L268L; 1:2150906-2150906	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.111C>T; p.F37F; 1:2055480-2055480	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1486-2A>G; p.?; 1:2175222-2175222	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.139A>G; p.M47V; 1:2055508-2055508	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.947T>C; p.L316S; 1:2156065-2156065	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1180G>T; p.D394Y; 1:2172173-2172173	NS	malignant_melanoma	Substitution - Missense
c.1327G>C; p.E443Q; 1:2173938-2173938	urinary_tract; bladder	carcinoma	Substitution - Missense
c.251G>A; p.R84H; 1:2056541-2056541	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1158G>A; p.A386A; 1:2172151-2172151	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1001A>G; p.N334S; 1:2169544-2169544	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1001A>G; p.N334S; 1:2169544-2169544	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1001A>G; p.N334S; 1:2169544-2169544	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1001A>G; p.N334S; 1:2169544-2169544	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1633C>A; p.L545M; 1:2184640-2184640	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.683C>T; p.S228L; 1:2148920-2148920	skin	malignant_melanoma	Substitution - Missense
c.318A>G; p.P106P; 1:2059575-2059575	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1575G>T; p.L525F; 1:2175313-2175313	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1057G>A; p.A353T; 1:2169600-2169600	oesophagus	carcinoma	Substitution - Missense
c.242G>A; p.R81H; 1:2056532-2056532	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.603C>T; p.D201D; 1:2146077-2146077	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.603C>T; p.D201D; 1:2146077-2146077	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.809G>A; p.R270Q; 1:2150911-2150911	skin	malignant_melanoma	Substitution - Missense
c.966G>A; p.T322T; 1:2156084-2156084	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.966G>A; p.T322T; 1:2156084-2156084	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.311G>T; p.G104V; 1:2059568-2059568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.377A>G; p.Y126C; 1:2135304-2135304	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1405G>T; p.V469L; 1:2174016-2174016	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1405G>T; p.V469L; 1:2174016-2174016	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.618C>T; p.S206S; 1:2146092-2146092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.84C>T; p.I28I; 1:2055453-2055453	skin	malignant_melanoma	Substitution - coding silent
c.907G>A; p.V303M; 1:2156025-2156025	lung	carcinoid-endocrine_tumour; typical	Substitution - Missense
c.907G>A; p.V303M; 1:2156025-2156025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1347C>T; p.S449S; 1:2173958-2173958	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1135C>T; p.L379L; 1:2172128-2172128	skin	malignant_melanoma	Substitution - coding silent
c.317C>G; p.P106R; 1:2059574-2059574	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.264T>C; p.D88D; 1:2056554-2056554	thyroid	other; neoplasm	Substitution - coding silent
c.264T>C; p.D88D; 1:2056554-2056554	thyroid	other; neoplasm	Substitution - coding silent
c.581C>T; p.P194L; 1:2146055-2146055	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1510C>T; p.R504W; 1:2175248-2175248	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.380G>A; p.R127H; 1:2135307-2135307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.778C>A; p.R260S; 1:2150880-2150880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1691+2T>C; p.?; 1:2184700-2184700	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.368G>T; p.R123M; 1:2135295-2135295	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1336G>A; p.A446T; 1:2173947-2173947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1350G>A; p.P450P; 1:2173961-2173961	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.624G>C; p.E208D; 1:2146098-2146098	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1337C>T; p.A446V; 1:2173948-2173948	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1630G>A; p.G544S; 1:2184637-2184637	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1630G>A; p.G544S; 1:2184637-2184637	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.777G>T; p.G259G; 1:2150879-2150879	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.121T>C; p.C41R; 1:2055490-2055490	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]