| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3689 |
Name | ITGB2 |
Synonymous | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit);ITGB2;integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
Definition | cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta chain, beta 2|integrin beta-2|leukocyte cell adhesion molecule CD18|leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C |
Position | 21q22.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | beta2-integrin(h) + JAB1(h) <==> beta2-integrin(h):JAB1(h) (binding) | beta2-integrin(h) + RACK1(h) <==> beta2-integrin(h):RACK1(h) (binding) | beta2-integrin(h) + Syk(h) <==> beta2-integrin(h):Syk(h) (binding) | beta2-integrin(h) + factor H(h) <==> beta2-integrin(h):factor H(h) (binding) | LPA(h) + beta2-integrin(h) <==> LPA(h):beta2-integrin(h) (binding) | LPA(m.s.) + beta2-integrin(h) <==> LPA(m.s.):beta2-integrin(h) (binding) | CD91(h) + beta2-integrin(h) <==> CD91(h):beta2-integrin(h) (binding) | beta2-integrin(h) + CD91(h) <==> beta2-integrin(h):CD91(h) (binding) | beta2-integrin(h) + lactosylceramide <==> beta2-integrin(h):lactosylceramide (binding) | beta2-integrin(h) + ATP --> beta2-integrin(h){p} + ADP (phosphorylation) | beta2-integrin(h) + ME491(h) <==> beta2-integrin(h):ME491(h) (binding) | ITGB2(h) --> beta2-integrin(h) (expression). | TNF-alpha(h) --> beta2-integrin(h) (increase of abundance) | fMLP-R(m.s.) --> beta2-integrin(h) (increase of abundance) | CD11D(h) + beta2-integrin(h) <==> CD11D(h):beta2-integrin(h) (binding) | beta2-integrin(h) + CD11B(h) <==> CD11B(h):beta2-integrin(h) (binding) | ITGB2(h) --> beta2-integrin(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 23 | Pyrrolidone carboxylic acid. | Swiss-Prot 53.0 | 50 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 116 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 212 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 254 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 501 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 642 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 745 | Phosphoserine (by PKC). | Swiss-Prot 53.0 | 756 | Phosphoserine. | Swiss-Prot 53.0 | 758 | Phosphothreonine; by PKC; in vitro. | Swiss-Prot 53.0 | 759 | Phosphothreonine (Potential). | Swiss-Prot 53.0 | 760 | Phosphothreonine; by PKC/PRKCA; in vitro. | Swiss-Prot 53.0 | 745 | Phosphoserine (PKC alpha;PK) | 11700305 | Phospho.ELM 6.0 | 758 | Phosphothreonine (PKC alpha;PK) | 11700305;12682249 | Phospho.ELM 6.0 | 759 | Phosphothreonine | 12682249 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for ITGB2 | ||