| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3689 |
Name | ITGB2 |
Synonym | CD18|LAD|LCAMB|LFA-1|MAC-1|MF17|MFI7;integrin, beta 2 (complement component 3 receptor 3 and 4 subunit);ITGB2;integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
Definition | cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta chain, beta 2|integrin beta-2|leukocyte cell adhesion molecule CD18|leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C |
Position | 21q22.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Malaria;KEGG PATHWAY;hsa05144 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Paxillin-dependent events mediated by a4b1;PID Curated;200117 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Staphylococcus aureus infection;KEGG PATHWAY;hsa05150 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | CXCR3-mediated signaling events;PID Curated;200150 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | Colon cancer;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | Leukocyte adhesion deficiency;OMIM |
Disease | Enteritis;FunDO |
Disease | Immune system diseases;KEGG DISEASE |
Disease | CARDIOVASCULAR;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Pertussis;FunDO |
Disease | Obesity;FunDO |
Disease | Stroke;FunDO |
Disease | Melanoma;FunDO |
Disease | Migraine;FunDO |
Disease | Kidney failure;FunDO |
Disease | HIV infection;FunDO |
Disease | restenosis;GAD |
Disease | reduced risk of restenosis after coronary stenting;GAD |
Disease | Leukocyte adhesion deficiency;KEGG DISEASE;H00099 |
Disease | Chronic obstructive airway disease;FunDO |
Disease | Thrombophilia;FunDO |
External Links | |
Links to Entrez Gene | 3689 |
Links to all GeneRIF Items | 3689 |
Links to iHOP | 3689 |
Sequence Information | |
Nucleotide Sequence | >3689 : length: 2979 AAGTGTCAGGACTTTACGACCCGCGCCTCCAGCTGAGGTTTCTAGACGTGACCCAGGGCA GACTGGTAGCAAAGCCCCCACGCCCAGCCAGGAGCACCGCCGAGGACTCCAGCACACCGA GGGACATGCTGGGCCTGCGCCCCCCACTGCTCGCCCTGGTGGGGCTGCTCTCCCTCGGGT GCGGTGAGTTCTGTGTTCCACGGAGGGGACTCCACGCGTGACATTCCAATCAGGGAGAAC AGGGCCTGCCCTCACTTTCCCATAGACAGAAGTTCCCGGGAGGCTGGGGAAGGACCTTGC CACTGGGGTCCTCTCTCAGGAGTGCACGAAGTTCAAGGTCAGCAGCTGCCGGGAATGCAT CGAGTCGGGGCCCGGCTGCACCTGGTGCCAGAAGCTGAACTTCACAGGGCCGGGGGATCC TGACTCCATTCGCTGCGACACCCGGCCACAGCTGCTCATGAGGGGCTGTGCGGCTGACGA CATCATGGACCCCACAAGCCTCGCTGAAACCCAGGAAGACCACAATGGGGGCCAGAAGCA GCTGTCCCCACAAAAAGTGACGCTTTACCTGCGACCAGGCCAGGCAGCAGCGTTCAACGT GACCTTCCGGCGGGCCAAGGGCTACCCCATCGACCTGTACTATCTGATGGACCTCTCCTA CTCCATGCTTGATGACCTCAGGAATGTCAAGAAGCTAGGTGGCGACCTGCTCCGGGCCCT CAACGAGATCACCGAGTCCGGCCGCATTGGCTTCGGGTCCTTCGTGGACAAGACCGTGCT GCCGTTCGTGAACACGCACCCTGATAAGCTGCGAAACCCATGCCCCAACAAGGAGAAAGA GTGCCAGCCCCCGTTTGCCTTCAGGCACGTGCTGAAGCTGACCAACAACTCCAACCAGTT TCAGACCGAGGTCGGGAAGCAGCTGATTTCCGGAAACCTGGATGCACCCGAGGGTGGGCT GGACGCCATGATGCAGGTCGCCGCCTGCCCGGAGGAAATCGGCTGGCGCAACGTCACGCG GCTGCTGGTGTTTGCCACTGATGACGGCTTCCATTTCGCGGGCGACGGGAAGCTGGGCGC CATCCTGACCCCCAACGACGGCCGCTGTCACCTGGAGGACAACTTGTACAAGAGGAGCAA CGAATTCGACTACCCATCGGTGGGCCAGCTGGCGCACAAGCTGGCTGAAAACAACATCCA GCCCATCTTCGCGGTGACCAGTAGGATGGTGAAGACCTACGAGAAACTCACCGAGATCAT CCCCAAGTCAGCCGTGGGGGAGCTGTCTGAGGACTCCAGCAATGTGGTCCATCTCATTAA GAATGCTTACAATAAACTCTCCTCCAGGGTCTTCCTGGATCACAACGCCCTCCCCGACAC CCTGAAAGTCACCTACGACTCCTTCTGCAGCAATGGAGTGACGCACAGGAACCAGCCCAG AGGTGACTGTGATGGCGTGCAGATCAATGTCCCGATCACCTTCCAGGTGAAGGTCACGGC CACAGAGTGCATCCAGGAGCAGTCGTTTGTCATCCGGGCGCTGGGCTTCACGGACATAGT GACCGTGCAGGTTCTTCCCCAGTGTGAGTGCCGGTGCCGGGACCAGAGCAGAGACCGCAG CCTCTGCCATGGCAAGGGCTTCTTGGAGTGCGGCATCTGCAGGTGTGACACTGGCTACAT TGGGAAAAACTGTGAGTGCCAGACACAGGGCCGGAGCAGCCAGGAGCTGGAAGGAAGCTG CCGGAAGGACAACAACTCCATCATCTGCTCAGGGCTGGGGGACTGTGTCTGCGGGCAGTG CCTGTGCCACACCAGCGACGTCCCCGGCAAGCTGATATACGGGCAGTACTGCGAGTGTGA CACCATCAACTGTGAGCGCTACAACGGCCAGGTCTGCGGCGGCCCGGGGAGGGGGCTCTG CTTCTGCGGGAAGTGCCGCTGCCACCCGGGCTTTGAGGGCTCAGCGTGCCAGTGCGAGAG GACCACTGAGGGCTGCCTGAACCCGCGGCGTGTTGAGTGTAGTGGTCGTGGCCGGTGCCG CTGCAACGTATGCGAGTGCCATTCAGGCTACCAGCTGCCTCTGTGCCAGGAGTGCCCCGG CTGCCCCTCACCCTGTGGCAAGTACATCTCCTGCGCCGAGTGCCTGAAGTTCGAAAAGGG CCCCTTTGGGAAGAACTGCAGCGCGGCGTGTCCGGGCCTGCAGCTGTCGAACAACCCCGT GAAGGGCAGGACCTGCAAGGAGAGGGACTCAGAGGGCTGCTGGGTGGCCTACACGCTGGA GCAGCAGGACGGGATGGACCGCTACCTCATCTATGTGGATGAGAGCCGAGAGTGTGTGGC AGGCCCCAACATCGCCGCCATCGTCGGGGGCACCGTGGCAGGCATCGTGCTGATCGGCAT TCTCCTGCTGGTCATCTGGAAGGCTCTGATCCACCTGAGCGACCTCCGGGAGTACAGGCG CTTTGAGAAGGAGAAGCTCAAGTCCCAGTGGAACAATGATAATCCCCTTTTCAAGAGCGC CACCACGACGGTCATGAACCCCAAGTTTGCTGAGAGTTAGGAGCACTTGGTGAAGACAAG GCCGTCAGGACCCACCATGTCTGCCCCATCACGCGGCCGAGACATGGCTTGCCACAGCTC TTGAGGATGTCACCAATTAACCAGAAATCCAGTTATTTTCCGCCCTCAAAATGACAGCCA TGGCCGGCCGGGTGCTTCTGGGGGCTCGTCGGGGGGACAGCTCCACTCTGACTGGCACAG TCTTTGCATGGAGACTTGAGGAGGGAGGGCTTGAGGTTGGTGAGGTTAGGTGCGTGTTTC CTGTGCAAGTCAGGACATCAGTCTGATTAAAGGTGGTGCCAATTTATTTACATTTAAACT TGTCAGGGTATAAAATGACATCCCATTAATTATATTGTTAATCAATCACGTGTATAGAAA AAAAATAAAACTTCAATACAGGCTGTCCATGGAAACTGG |
Protein Sequence | >3689 : length: 769 MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSI RCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFR RAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFV NTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAM MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAY NKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATEC IQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKN CECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTIN CERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGR TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLL VIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES |