| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2885 |
Name | GRB2 |
Synonymous | growth factor receptor-bound protein 2;GRB2;growth factor receptor-bound protein 2 |
Definition | HT027|SH2/SH3 adapter GRB2|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3|protein Ash |
Position | 17q24-q25 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Grb-2(h) + SPIN90-xbb1(m) <==> Grb-2(h):SPIN90-xbb1(m) (binding) | Grb-2(h) + Pyk2-isoform1(h) <==> Grb-2(h):Pyk2-isoform1(h) (binding) | Grb-2(h) + p66Shb(h) <==> Grb-2(h):p66Shb(h) (binding) | FasL(h) + Grb-2(h) <==> FasL(h):Grb-2(h) (binding) | c-Kit(h){pY703} + Grb-2(h) <==> c-Kit(h){pY703}:Grb-2(h) (binding) | c-Kit(h){pY936} + Grb-2(h) <==> c-Kit(h){pY936}:Grb-2(h) (binding) | ErbB2(h){pY1139} + Grb-2(h) <==> ErbB2(h){pY1139}:Grb-2(h) (binding) | c-Cbl(h){pY} + Grb-2(h) <==> c-Cbl(h){pY}:Grb-2(h) (binding) | c-Cbl(h) + Grb-2(h) <==> c-Cbl(h):Grb-2(h) (binding) | Grb-2(h) + SHIP-110(h) <==> Grb-2(h):SHIP-110(h) (binding) | IRS-1(h) + Grb-2(h) <==> IRS-1(h):Grb-2(h) (binding) | IRS-2(h) + Grb-2(h) <==> IRS-2(h):Grb-2(h) (binding) | Grb-2(h) + p65PAK(h) <==> Grb-2(h):p65PAK(h) (binding) | EGFR(h){pY} + Grb-2(h) <==> EGFR(h){pY}:Grb-2(h) (binding) | Grb-2(h) + synaptojanin 2A(r) <==> Grb-2(h):synaptojanin 2A(r) (binding) | Grb-2(h) + Synaptojanin1(r) <==> Grb-2(h):Synaptojanin1(r) (binding) | Grb-2(h) + synaptojanin 2B1(r) <==> Grb-2(h):synaptojanin 2B1(r) (binding) | Grb-2(h) + synaptojanin 2B2(r) <==> Grb-2(h):synaptojanin 2B2(r) (binding) | Grb-2(h) + Shc-1-p66(h) <==> Grb-2(h):Shc-1-p66(h) (binding) | Grb-2(h) + Shc-1-p52(h) <==> Grb-2(h):Shc-1-p52(h) (binding) | Grb-2(h) + Shc-1-p46(h) <==> Grb-2(h):Shc-1-p46(h) (binding) | Grb-2(h) + Synapsin-1(r) <==> Grb-2(h):Synapsin-1(r) (binding) | FAK1(m){pY397}{pY925}:Src(h) + Grb-2(h) <==> Src(h):FAK1(m){pY397}{pY925}:Grb-2(h) (binding) | M-CSF-1-R(h){pY} + Grb-2(h) <==> M-CSF-1-R(h){pY}:Grb-2(h) (binding) | Grb-2(h) + Shc-1-p46(h){pY} <==> Grb-2(h):Shc-1-p46(h){pY} (binding) | Grb-2(h) + Shc-1-p52(h){pY} <==> Grb-2(h):Shc-1-p52(h){pY} (binding) | FAK1(h){pY925} + Grb-2(h) <==> FAK1(h){pY925}:Grb-2(h) (binding) | Grb-2(h) + Sos(h) <==> Grb-2(h):Sos(h) (binding) | SHP-2(h){pY} + Grb-2(h) <==> SHP-2(h){pY}:Grb-2(h) (binding) | Grb-2(h) + Sos1(h) <==> Grb-2(h):Sos1(h) (binding) | huntingtin(h) + Grb-2(h) <==> huntingtin(h):Grb-2(h) (binding) | Grb-2(h) + PI3K-C2beta(h) <==> Grb-2(h):PI3K-C2beta(h) (binding) | Grb-2(h) + WASP(h) <==> Grb-2(h):WASP(h) (binding) | Gab-1(h){pY} + Grb-2(h) + p85(h) + SHP-2(h){pY} <==> p85(h):Grb-2(h):SHP-2(h){pY}:Gab-1(h){pY} (binding) | Grb-2(h) + p85(h) + SHP-2(h){pY} + Gab-2(h){pY} <==> Grb-2(h):p85(h):SHP-2(h){pY}:Gab-2(h){pY} (binding) | RN-tre(m.s.) + Grb-2(h) <==> RN-tre(m.s.):Grb-2(h) (binding) | Grb-2(h) + RN-tre(m.s.) + EGFR(m.s.){pY} <==> Grb-2(h):RN-tre(m.s.):EGFR(m.s.){pY} (binding) | CD28(h) + Grb-2(h) <==> CD28(h):Grb-2(h) (binding) | Grb-2(h) + hnRNP-C(h) <==> Grb-2(h):hnRNP-C(h) (binding) | Grb-2(h) + arachidonate 5-lipoxygenase(h) <==> Grb-2(h):arachidonate 5-lipoxygenase(h) (binding) | Shc-1(h) + Grb-2(h) <==> Shc-1(h):Grb-2(h) (binding) | Grb-2(h) + ErbB2(h){pY} <==> Grb-2(h):ErbB2(h){pY} (binding) | Grb-2(h) + ErbB3(h){pY} <==> Grb-2(h):ErbB3(h){pY} (binding) | pde6g(m) + Grb-2(h) <==> pde6g(m):Grb-2(h) (binding) | Grb-2(h) + IRS-2(h){pY} <==> Grb-2(h):IRS-2(h){pY} (binding) | EPHB6(h) + Grb-2(h) <==> EPHB6(h):Grb-2(h) (binding) | DAP10(h){p} + Grb-2(h) <==> DAP10(h){p}:Grb-2(h) (binding) | Grb-2(h) + Syk(h){pY} <==> Grb-2(h):Syk(h){pY} (binding) | Grb-2(h) + Vav-3(m.s.){pY} <==> Grb-2(h):Vav-3(m.s.){pY} (binding) | Sos2(h) + Grb-2(h) <==> Sos2(h):Grb-2(h) (binding) | Shc-1-p52(h) + Sos(h) + Grb-2(h) <==> Shc-1-p52(h):Sos(h):Grb-2(h) (binding) | CrkL(h) + Grb-2(h) <==> CrkL(h):Grb-2(h) (binding) | Grb-2(h) + SHIP(h) + Sos(h) + Shc-1(h) <==> Grb-2(h):SHIP(h):Sos(h):Shc-1(h) (binding) | Grb-2(h) + ErbB4(h){pY} <==> Grb-2(h):ErbB4(h){pY} (binding) | Grb-2(h) + C3G(h) <==> Grb-2(h):C3G(h) (binding) | Grb-2(h) + C3G-L(h) <==> Grb-2(h):C3G-L(h) (binding) | Grb-2(h) + MAP-2(h) <==> Grb-2(h):MAP-2(h) (binding) | Vav-2(h) + Grb-2(h) + CD44(h) + ErbB2(h) <==> Vav-2(h):Grb-2(h):CD44(h):ErbB2(h) (binding) | Grb-2(h) + MUC4(m.s.):ErbB2(h) <==> ErbB2(h):Grb-2(h):MUC4(m.s.) (binding) | Grb-2(h) + ErbB2(h){pY1222} <==> Grb-2(h):ErbB2(h){pY1222} (binding) | Grb-2(h) + ErbB2(h){pY1248} <==> Grb-2(h):ErbB2(h){pY1248} (binding) | HCV-NS5A(HCV) + Grb-2(h) <==> HCV-NS5A(HCV):Grb-2(h) (binding) | Grb-2(h) + ErbB1(h) <==> Grb-2(h):ErbB1(h) (binding) | ErbB1-p170(h){pY1138} + Grb-2(h) <==> Grb-2(h):ErbB1-p170(h){pY1138} (binding) | ErbB2(h){pY1139} + Grb-2(h) <==> ErbB2(h){pY1139}:Grb-2(h) (binding) | Grb-2(h) + HCV-NS5A-1B(HCV1B) <==> Grb-2(h):HCV-NS5A-1B(HCV1B) (binding) | ErbB1(h){pY} + Grb-2(h) + Shc-1(h){pY} <==> Shc-1(h){pY}:ErbB1(h){pY}:Grb-2(h) (binding) | Shc-1(h){pY} + Grb-2(h) <==> Shc-1(h){pY}:Grb-2(h) (binding) | ErbB1(h){pY} + c-Cbl(h){pY} + Grb-2(h) <==> ErbB1(h){pY}:c-Cbl(h){pY}:Grb-2(h) (binding) | Grb-2(h) + FRS2(h) <==> Grb-2(h):FRS2(h) (binding) | ErbB1(h){pY} + Grb-2(h) <==> ErbB1(h){pY}:Grb-2(h) (binding) | Grb-2(h) + ErbB1-p170(h){pY} <==> Grb-2(h):ErbB1-p170(h){pY} (binding) | Grb-2(h) + ErbB3(r){pY} <==> Grb-2(h):ErbB3(r){pY} (binding) | Grb-2(h) + ATP --> Grb-2(h){pY} + ADP (phosphorylation) | Shc(c){pY} + ErbB1(c){pY} + Grb-2(h) <==> Shc(c){pY}:ErbB1(c){pY}:Grb-2(h) (binding) | Grb-2(h) + PDGFR(m.s.) <==> Grb-2(h):PDGFR(m.s.) (binding) | c-Cbl(h) + CrkL(h) + Grb-2(h) <==> c-Cbl(h):CrkL(h):Grb-2(h) (binding) | LAT(h) + Grb-2(h) <==> LAT(h):Grb-2(h) (binding) | Grb-2(h) + SLP-76(h){pY} <==> Grb-2(h):SLP-76(h){pY} (binding) | trkA(h) + Grb-2(h) <==> trkA(h):Grb-2(h) (binding) | Grb-2(h) + Src(h) <==> Grb-2(h):Src(h) (binding) | Grb-2(h) + APS(r) <==> Grb-2(h):APS(r) (binding) | SH2-B(r) + Grb-2(h) <==> SH2-B(r):Grb-2(h) (binding) | Grb-2(h) + CD229(h) <==> Grb-2(h):CD229(h) (binding) | Grb-2(h) + CD229(h){pY} <==> Grb-2(h):CD229(h){pY} (binding) | POB1-isoform2(h) + Grb-2(h) <==> Grb-2(h):POB1-isoform2(h) (binding) | Grb-2(h) + POB1(h) <==> Grb-2(h):POB1(h) (binding) | c-Kit(h){pY703}{pY936} + Grb-2(h) <==> c-Kit(h){pY703}{pY936}:Grb-2(h) (binding) | Grb-2(h) + Shc-1-p66(h){pY} <==> Grb-2(h):Shc-1-p66(h){pY} (binding) | Plexin-B1-isoform1(h) + Grb-2(h) <==> Plexin-B1-isoform1(h):Grb-2(h) (binding) | Grb-2(h) + Plexin-B1(h) <==> Grb-2(h):Plexin-B1(h) (binding) | Grb-2(h) + SHP-2(h) <==> Grb-2(h):SHP-2(h) (binding) | Grb-2(h) + Vav(h) <==> Grb-2(h):Vav(h) (binding) | Grb-2(h) + LAT-Short(h){pY} <==> Grb-2(h):LAT-Short(h){pY} (binding) | Grb-2(h) + LAT(m.s.){pY} <==> Grb-2(h):LAT(m.s.){pY} (binding) | PLCgamma1(h) + Grb-2(h) + LAT(h){pY} <==> PLCgamma1(h):Grb-2(h):LAT(h){pY} (binding) | Sos1(h) + Grb-2(h) <==> Sos1(h):Grb-2(h) (binding) | LAT(h) + p56Dok-2(h) + SHIP(h) + Grb-2(h) <==> LAT(h):p56Dok-2(h):SHIP(h):Grb-2(h) (binding) | gp130(h) + Grb-2(h) <==> gp130(h):Grb-2(h) (binding) | Grb-2(h) + gp130-isoform1(h) <==> Grb-2(h):gp130-isoform1(h) (binding) | Sos1(h) + Grb-2(h) + CD3zeta(h){pY} <==> Sos1(h):Grb-2(h):CD3zeta(h){pY} (binding) | Grb-2(h) + CD3zeta(h) <==> Grb-2(h):CD3zeta(h) (binding) | CD3zeta-isoform1(h){pY} + Grb-2(h) <==> CD3zeta-isoform1(h){pY}:Grb-2(h) (binding) | Grb-2(h) + LAT(h){pY} <==> Grb-2(h):LAT(h){pY} (binding) | GRB2(h) --> Grb-2(h) (expression). | Grb-2-Isoform1(h) + Cas(r) <==> Grb-2-Isoform1(h):Cas(r) (binding) | Grb-2-Isoform1(h) + Shc-1-p52(r){pY} <==> Grb-2-Isoform1(h):Shc-1-p52(r){pY} (binding) | ErbB1(h){pY} + Grb-2-Isoform1(h) <==> ErbB1(h){pY}:Grb-2-Isoform1(h) (binding) | Grb-2-Isoform1(h) + Shc-1-p46(r){pY} <==> Grb-2-Isoform1(h):Shc-1-p46(r){pY} (binding) | Grb-2-Isoform1(h) + Shc-1-p66(r){pY} <==> Grb-2-Isoform1(h):Shc-1-p66(r){pY} (binding) | Src(r) + Grb-2-Isoform1(h) <==> Src(r):Grb-2-Isoform1(h) (binding) | GRB2(h) --> Grb-2-Isoform1(h) (expression). | GRB2(h) --> GRB3-3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 160 | Phosphotyrosine. | Swiss-Prot 53.0 | 209 | Phosphotyrosine. | Swiss-Prot 53.0 | 209 | Phosphotyrosine (Abl;EGFR) | 11726515 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 70912884 - 70914884 | Agilent_014791 |
chr17 |
Promoter: 70912829 - 70914829 | Agilent_014791 |
chr17 |
Promoter: 70912829 - 70914829 | GSE27584 |
chr17 |
Promoter: 70912884 - 70914884 | GSE27584 |
chr17 |
Promoter: 70912884 - 70914884 | Agilent_014791_44K |