| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2885 |
Name | GRB2 |
Synonym | ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2;growth factor receptor-bound protein 2;GRB2;growth factor receptor-bound protein 2 |
Definition | HT027|SH2/SH3 adapter GRB2|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3|protein Ash |
Position | 17q24-q25 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | role of erbb2 in signal transduction and oncology;PID BioCarta;100147 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | insulin signaling pathway;PID BioCarta;100124 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | the igf-1 receptor and longevity;PID BioCarta;100115 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | erk1/erk2 mapk signaling pathway;PID BioCarta;100170 |
Pathway | nfat and hypertrophy of the heart ;PID BioCarta;100098 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | mcalpain and friends in cell motility;PID BioCarta;100111 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Pathway | trka receptor signaling pathway;PID BioCarta;100011 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation;PID BioCarta;100135 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Grb2 events in EGFR signaling;PID Reactome;500512 |
Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032 |
Pathway | Costimulation by the CD28 family;PID Reactome;500483 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | EGFR-dependent Endothelin signaling events;PID Curated;200095 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | cbl mediated ligand-induced downregulation of egf receptors pathway;PID BioCarta;100216 |
Pathway | growth hormone signaling pathway;PID BioCarta;100155 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | epo signaling pathway;PID BioCarta;100175 |
Pathway | CD28 dependent Vav1 pathway;PID Reactome;500486 |
Pathway | Downstream signaling of activated FGFR;PID Reactome;500247 |
Pathway | Signal attenuation;PID Reactome;500505 |
Pathway | Grb2:SOS provides linkage to MAPK signaling for Intergrins;PID Reactome;500006 |
Pathway | SHC-mediated signalling;PID Reactome;500496 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Signalling to RAS;PID Reactome;500626 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | transcription factor creb and its extracellular signals;PID BioCarta;100198 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gab1 signalosome;PID Reactome;500514 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Tie2 Signaling;PID Reactome;500306 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | EGFR downregulation;PID Reactome;500515 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Signaling by EGFR;PID Reactome;500510 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | SOS-mediated signalling;PID Reactome;500504 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | the co-stimulatory signal during t-cell activation;PID BioCarta;100193 |
Pathway | nerve growth factor pathway (ngf);PID BioCarta;100096 |
Pathway | NCAM signaling for neurite out-growth;PID Reactome;500079 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Down-stream signal transduction;PID Reactome;500509 |
Pathway | Internalization of ErbB1;PID Curated;200146 |
Pathway | vegf hypoxia and angiogenesis;PID BioCarta;100006 |
Pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | il 4 signaling pathway;PID BioCarta;100127 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | Shc events in EGFR signaling;PID Reactome;500513 |
Pathway | il 3 signaling pathway;PID BioCarta;100128 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | SHC-mediated cascade;PID Reactome;500250 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Dorso-ventral axis formation;KEGG PATHWAY;hsa04320 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | IL2 signaling events mediated by STAT5;PID Curated;200158 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | il 2 signaling pathway;PID BioCarta;100130 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | PI-3K cascade;PID Reactome;500251 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | FRS2-mediated cascade;PID Reactome;500248 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | il 6 signaling pathway;PID BioCarta;100126 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | FGF signaling pathway;PID Curated;200189 |
External Links | |
Links to Entrez Gene | 2885 |
Links to all GeneRIF Items | 2885 |
Links to iHOP | 2885 |
Sequence Information | |
Nucleotide Sequence | >2885 : length: 3303 AGTTCTCGCGGGACACCGACGGGGAGCGGAAGCCAGGAGGTATTGCTGCTTCGGCGACCG GGCGGCGGCAGCGGCGGCGGCGGCTGTGGCAGAGTCTGTGCCTGTGGCGGTGACGGCGGC GGGAGCAAGCGCTGCCCTCGCAGAGCAGCCTTGGGGTCGCCGGCCGCTCGCAGCGTTGTG GAGGGGCGGGCCGGACGCTGAGCGGAGCAGCTGCGCCACGGGTGGCATTGTGTGTCCCAG AGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTTGCTTCA GCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATG GAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGG GGGGACATCCTCAAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTT AATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTT TTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGG GCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTT GGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGG GTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCC AGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTC CAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGAT TTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAG ACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGA AGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAG CTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACC CTCTCACTTTGGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAA ACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCTTTCCC CTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAG GCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTAT TCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGAAGAACAGCTGTTCCTG TGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTT AGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTA TTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCT TCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTG GGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGT GAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCC AGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGA GCCGGGACCGTGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAA AAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTCCAGTGGG ATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGA GTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAG AGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTCCCTCCGGGCAGGGGAG CCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTAC TAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGA ACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGAC CGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTC ACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGT CCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTT TCACTATTCCTATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTT AGATTGGGCCATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAG CACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACTGCTGC TCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAA GACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGT GGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCACGACAAAAACAAGACT GCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGA TGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGC CAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATC CTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTT GATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTG TATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACT CTGCGGATAGCATTTGGTAGGTAGTGATTAACTGTGAATAATAAATACACAATGAATTCT TCA |
Protein Sequence | >2885 : length: 217 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV |